Low-intensity exercise combined with sodium valproate attenuates kainic acid-induced seizures and associated co-morbidities by inhibiting NF-κB signaling in mice

Autor: Yuxiang Jia, Lele Tang, Yu Yao, Limin Zhuo, Dongxiao Qu, Xingxing Chen, Yonghua Ji, Jie Tao, Yudan Zhu

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

Sodium valproate (VPA) is a broad-spectrum anticonvulsant that is effective both in adults and children suffering from epilepsy, but it causes psychiatric and behavioral side effects in patients with epilepsy. In addition, 30% of patients with epilep

Externí odkaz: https://doaj.org/article/b4c823e760094569b4ce12b568bb673b

Molecular Mechanisms of Epileptic Encephalopathy Caused by KCNMA1 Loss-of-Function Mutations

Autor: Yu Yao, Dongxiao Qu, Xiaoping Jing, Yuxiang Jia, Qi Zhong, Limin Zhuo, Xingxing Chen, Guoyi Li, Lele Tang, Yudan Zhu, Xuemei Zhang, Yonghua Ji, Zhiping Li, Jie Tao

Publikováno v: Frontiers in Pharmacology, Vol 12 (2022)

The gene kcnma1 encodes the α-subunit of high-conductance calcium- and voltage-dependent K+ (BK) potassium channel. With the development of generation gene sequencing technology, many KCNMA1 mutants have been identified and are more closely related

Externí odkaz: https://doaj.org/article/ed9c18b78df443bdb13f3e332175f9f0

Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats.

Autor: Dongxiao QU; Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China., Yiqin GE; Department of Neurosurgery, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201803, China., Limin Z; College of Sciences, Shanghai University, Shanghai 200442, China., Liji C; Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China., Yonghua X; Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.; 3 Department of Neurology and Central Laboratory, Putuo Clinical Medical School, Anhui Medical University, Shanghai 200062, China., Jiwei C; Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.; 3 Department of Neurology and Central Laboratory, Putuo Clinical Medical School, Anhui Medical University, Shanghai 200062, China., Jie T; Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.; 3 Department of Neurology and Central Laboratory, Putuo Clinical Medical School, Anhui Medical University, Shanghai 200062, China., Guoyi LI; Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.; 3 Department of Neurology and Central Laboratory, Putuo Clinical Medical School, Anhui Medical University, Shanghai 200062, China., Yudan Z; Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China., Qian X; Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.

Publikováno v: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan [J Tradit Chin Med] 2023 Apr; Vol. 43 (2), pp. 286-294.