Epcoritamab, a Novel, Subcutaneous CD3xCD20 Bispecific T-Cell-Engaging Antibody, in Relapsed or Refractory Large B-Cell Lymphoma

Autor: Catherine Thieblemont, Tycel Phillips, Herve Ghesquieres, Chan Y. Cheah, Michael Roost Clausen, David Cunningham, Young Rok Do, Tatyana Feldman, Robin Gasiorowski, Wojciech Jurczak, Tae Min Kim, David John Lewis, Marjolein van der Poel, Michelle Limei Poon, Mariana Cota Stirner, Nurgul Kilavuz, Christopher Chiu, Menghui Chen, Mariana Sacchi, Brian Elliott, Tahamtan Ahmadi, Martin Hutchings, Pieternella J. Lugtenburg

Publikováno v: Journal of Clinical Oncology, 41(12), 2238-2247. American Society of Clinical Oncology
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 41(12):JCO2201725, 2238-2247. American Society of Clinical Oncology

PURPOSE Epcoritamab is a subcutaneously administered CD3xCD20 T-cell–engaging, bispecific antibody that activates T cells, directing them to kill malignant CD20+ B cells. Single-agent epcoritamab previously demonstrated potent antitumor activity in

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https://cris.maastrichtuniversity.nl/en/publications/d1fc36c2-2d89-45b9-a114-20f08c25faba

Supplementary appendix from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Autor: Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe

Supplementary methods. Supplementary Figure 1. Phenotyping of B-cells in non-malignant tissues. A, Quantitation of marker positivity across ten tonsil and two reactive lymph node samples (rLN). Analysis is spatially resolved between the GC and extra-

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https://doi.org/10.1158/2159-8290.22758717.v1

Figure 1 from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Autor: Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe

Quantitative single-cell analysis of MYC, BCL2, and BCL6 protein expression in B cells in nonmalignant tissues and diffuse large B-cell lymphoma. A, Schematic workflow of a quantitative digital pathology experiment. B, Spectrally unmixed multiplexed

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https://doi.org/10.1158/2159-8290.22758738.v1

Table 1 from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Autor: Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe

Multivariate analysis of continuous M+2+6− percentage extent at 5% increments as a predictor of OS in the NUH, SGH, and MDA cohorts of DLBCL (Cox proportional hazards model)

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https://doi.org/10.1158/2159-8290.22758711.v1

Figure 3 from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma

Autor: Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe

MYC, BCL2, and BCL6 protein coexpression in DLBCL can be inferred from individual marker data. A, Schematic of possible relationships between expression of three oncogenes in a population of cells. The distribution of these oncogenes can either refle

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https://doi.org/10.1158/2159-8290.22758732.v1