Methyltransferase Contingencies in the Pathway of Everninomicin D Antibiotics and Analogues.

Autor: Limbrick EM; Department of Chemistry, Vanderbilt University, 7330 Stevenson Ctr, Nashville, TN 37235, USA.; Department of Chemistry, Mercer University, 1501 Mercer University Drive, Macon, GA 31207, USA., Yñigez-Gutierrez AE; Department of Chemistry, Vanderbilt University, 7330 Stevenson Ctr, Nashville, TN 37235, USA., Dulin CC; Department of Chemistry, Vanderbilt University, 7330 Stevenson Ctr, Nashville, TN 37235, USA., Derewacz DK; Department of Chemistry, Vanderbilt University, 7330 Stevenson Ctr, Nashville, TN 37235, USA., Spraggins JM; Department of Chemistry, Vanderbilt University, 7330 Stevenson Ctr, Nashville, TN 37235, USA.; Department of Biochemistry, Vanderbilt University School of Medicine, 607 Light Hall, Nashville, TN 37205, USA.; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, 465 21st Ave S, Nashville, TN 37240, USA., McCulloch KM; Department of Pharmacology, Vanderbilt University 7124 MRBIII, 465 21st Ave S, Nashville, TN 37232, USA.; Department of Chemistry & Biochemistry, California State Polytechnic University, Pomona, 3801 West Temple Ave, Pomona, CA 91768, USA., Iverson TM; Department of Biochemistry, Vanderbilt University School of Medicine, 607 Light Hall, Nashville, TN 37205, USA.; Department of Pharmacology, Vanderbilt University 7124 MRBIII, 465 21st Ave S, Nashville, TN 37232, USA.; Vanderbilt Institute of Chemical Biology.; Vanderbilt Center for Structural Biology., Bachmann BO; Department of Chemistry, Vanderbilt University, 7330 Stevenson Ctr, Nashville, TN 37235, USA.; Department of Biochemistry, Vanderbilt University School of Medicine, 607 Light Hall, Nashville, TN 37205, USA.; Department of Pharmacology, Vanderbilt University 7124 MRBIII, 465 21st Ave S, Nashville, TN 37232, USA.; Vanderbilt Institute of Chemical Biology.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2020 Dec 01; Vol. 21 (23), pp. 3349-3358. Date of Electronic Publication: 2020 Sep 07.

Bifunctional Nitrone-Conjugated Secondary Metabolite Targeting the Ribosome.

Autor: Limbrick EM; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States., Graf M; Institute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg 20146, Germany., Derewacz DK; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States., Nguyen F; Department of Biochemistry, University of Munich, 81377 Munich, Germany., Spraggins JM; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37205, United States.; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Wieland M; Institute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg 20146, Germany., Ynigez-Gutierrez AE; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States., Reisman BJ; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States., Zinshteyn B; Department of Molecular Biology and Genetics, Johns Hopkins University. Baltimore, Maryland 21205, United States., McCulloch KM; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Iverson TM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37205, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Center for Structural Biology, Nashville, Tennessee 37232, United States., Green R; Department of Molecular Biology and Genetics, Johns Hopkins University. Baltimore, Maryland 21205, United States.; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Wilson DN; Institute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg 20146, Germany., Bachmann BO; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37205, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Institute of Chemical Biology, Nashville, Tennessee 37205, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2020 Oct 28; Vol. 142 (43), pp. 18369-18377. Date of Electronic Publication: 2020 Oct 19.

Ribosome-targeting antibacterial agents: Advances, challenges, and opportunities.

Autor: Zhang L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China., He J; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China., Bai L; Center of Infectious Diseases, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China., Ruan S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China., Yang T; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China.; Laboratory of Human Diseases and Immunotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China.; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China., Luo Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China.

Publikováno v: Medicinal research reviews [Med Res Rev] 2021 Jul; Vol. 41 (4), pp. 1855-1889. Date of Electronic Publication: 2021 Jan 27.