Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study

Autor: Nepogodiev, D, Walker, K, Glasbey, JC, Drake, TM, Borakati, A, Kamarajah, S, McLean, K, Khatri, C, Arulkumaran, N, Harrison, EM, Fitzgerald, JE, Cromwell, D, Prowle, J, Bhangu, A, Bath, MF, Claireaux, HA, Gundogan, B, Mohan, M, Deekonda, P, Kong, C, Joyce, H, Mcnamee, L, Woin, E, Burke, J, Bell, S, Duthie, F, Hughes, J, Pinkney, TD, Richards, T, Thomas, M, Dynes, K, Patel, P, Wigley, C, Suresh, R, Shaw, A, Klimach, S, Jull, P, Evans, D, Preece, R, Ibrahim, I, Manikavasagar, V, Brown, FS, Teo, R, Sim, DPY, Logan, AE, Barai, I, Amin, H, Suresh, S, Sethi, R, Bolton, W, Corbridge, O, Horne, L, Attalla, M, Morley, R, Hoskins, T, McAllister, R, Lee, S, Dennis, Y, Nixon, G, Heywood, E, Wilson, H, Ng, L, Samaraweera, S, Mills, A, Doherty, C, Belchos, J, Phan, V, Chouari, T, Gardner, T, Goergen, N, Hayes, JDB, MacLeod, CS, McCormack, R, McKinley, A, McKinstry, S, Milligan, W, Ooi, L, Rafiq, NM, Sammut, T, Sinclair, E, Smith, M, Baker, C, Boulton, APR, Collins, J, Copley, HC, Fearnhead, N, Fox, H, Mah, T, McKenna, J, Naruka, V, Nigam, N, Nourallah, B, Perera, S, Qureshi, A, Saggar, S, Sun, L, Wang, X, Yang, DD, Caroll, P, Doyle, C, Elangovan, S, Falamarzi, A, Perai, KG, Greenan, E, Jain, D, Lang-Orsini, M, Lim, S, O'Byrne, L, Ridgway, P, Van der Laan, S, Wong, J, Arthur, J, Barclay, J, Bradley, P, Edwin, C, Finch, E, Hayashi, E, Hopkins, M, Kelly, D, Kelly, M, McCartan, N, Ormrod, A, Pakenham, A, Hayward, J, Hitchen, C, Kishore, A, Martins, T, Philomen, J, Rao, R, Rickards, C, Burns, N, Copeland, M, Durand, C, Dyal, A, Ghaffar, A, Gidwani, A, Grant, M, Gribbon, C, Gruhn, A, Leer, M, Ahmad, K, Beattie, G, Beatty, M, Campbell, G, Donaldson, G, Graham, S, Holmes, D, Kanabar, S, Liu, H, McCann, C, Stewart, R, Vara, S, Ajibola-Taylor, O, Andah, EJE, Ani, C, Cabdi, NMO, Ito, G, Jones, M, Komoriyama, A, Titu, L, Basra, M, Gallogly, P, Harinath, G, Leong, SH, Pradhan, A, Siddiqui, I, Zaat, S, Ali, A, Galea, M, Looi, WL, Ng, JCK, Atkin, G, Azizi, A, Cargill, Z, China, Z, Elliot, J, Jebakumar, R, Lam, J, Mudalige, G, Onyerindu, C, Renju, M, Babu, VS, Hussain, M, Joji, N, Lovett, B, Mownah, H, Ali, B, Cresswell, B, Dhillon, AK, Dupaguntla, YS, Hungwe, C, Lowe-Zinola, JD, Tsang, JCH, Bevan, K, Cardus, C, Duggal, A, Hossain, S, McHugh, M, Scott, M, Chan, F, Evans, R, Gurung, E, Haughey, B, Jacob-Ramsdale, B, Kerr, M, Lee, J, McCann, E, O'Boyle, K, Reid, N, Hayat, F, Hodgson, S, Johnston, R, Jones, W, Khan, M, Linn, T, Long, S, Seetharam, P, Shaman, S, Smart, B, Anilkumar, A, Davies, J, Griffith, J, Hughes, B, Islam, Y, Kidanu, D, Mushaini, N, Qamar, I, Robinson, H, Schramm, M, Tan, CY, Apperley, H, Billyard, C, Blazeby, JM, Cannon, SP, Carse, S, Gopfert, A, Loizidou, A, Parkin, J, Sanders, E, Sharma, S, Slade, G, Telfer, R, Huppatz, IW, Worley, E, Chandramoorthy, L, Friend, C, Harris, L, Jain, P, Karim, MJ, Killington, K, McGillicuddy, J, Rafferty, C, Rahunathan, N, Rayne, T, Varathan, Y, Verma, N, Zanichelli, D, Arneill, M, Brown, F, Campbell, B, Crozier, L, Henry, J, McCusker, C, Prabakaran, P, Wilson, R, Asif, U, Connor, M, Dindyal, S, Math, N, Pagarkar, A, Saleem, H, Seth, I, Standfield, N, Swartbol, T, Adamson, R, Choi, JE, El Tokhy, O, Ho, W, Javaid, NR, Mehdi, AS, Menon, D, Plumptre, I, Sturrock, S, Turner, J, Warren, O, Crane, E, Ferris, B, Gadsby, C, Smallwood, J, Vipond, M, Wilson, V, Amarnath, T, Doshi, A, Gregory, C, Kandiah, K, Powell, B, Spoor, H, Toh, C, Vizor, R, Common, M, Dunleavy, K, Harris, S, Luo, C, Mesbah, Z, Kumar, AP, Redmond, A, Skulsky, S, Walsh, T, Daly, D, Deery, L, Epanomeritakis, E, Harty, M, Kane, D, Khan, K, Mackey, R, McConville, J, McGinnity, K, Ang, A, Kee, JY, Leung, E, Norman, S, Palaniappan, S, Sarathy, PP, Yeoh, T, Frost, J, Hazeldine, P, Jones, L, Karbowiak, M, Macdonald, C, Mutarambirwa, A, Omotade, A, Runkel, M, Ryan, G, Sawers, N, Searle, C, Vig, S, Ahmad, A, McGartland, R, Sim, R, Song, A, Wayman, J, Brown, R, Chang, LH, Concannon, K, Crilly, C, Arnold, TJ, Burgin, A, Cadden, F, Choy, CH, Coleman, M, Lim, D, Luk, J, Mahankali-Rao, P, Prudence-Taylor, AJ, Ramakrishnan, D, Russell, J, Fawole, A, Gohil, J, Green, B, Hussain, A, McMenamin, L, Tang, M, Azmi, F, Benchetrit, S, Cope, T, Haque, A, Harlinska, A, Holdsworth, R, Ivo, T, Martin, J, Nisar, T, Patel, A, Sasapu, K, Trevett, J, Vernet, G, Aamir, A, Bird, C, Durham-Hall, A, Gibson, W, Hartley, J, May, N, Maynard, V, Johnson, S, Wood, CM, O'Brien, M, Orbell, J, Stringfellow, TD, Tenters, F, Tresidder, S, Cheung, W, Grant, A, Tod, N, Bews-Hair, M, Lim, ZH, Lim, SW, Vella-Baldacchino, M, Auckburally, S, Chopada, A, Easdon, S, Goodson, R, McCurdie, F, Narouz, M, Radford, A, Rea, E, Taylor, O, Yu, T, Alfa-Wali, M, Amani, L, Auluck, I, Bruce, P, Emberton, J, Kumar, R, Lagzouli, N, Mehta, A, Murtaza, A, Raja, M, Dennahy, IS, Frew, K, Given, A, He, YY, Karim, MA, MacDonald, E, McDonald, E, McVinnie, D, Ng, SK, Pettit, A, Berthaume-Hawkins, SD, Charnley, R, Fenton, K, Jones, D, Murphy, C, Ng, JQ, Reehal, R, Seraj, SS, Shang, E, Tonks, A, White, P, Yeo, A, Chong, P, Gabriel, R, Patel, N, Richardson, E, Symons, L, Aubrey-Jones, D, Dawood, S, Dobrzynska, M, Faulkner, S, Griffiths, H, Mahmood, F, Perry, M, Power, A, Simpson, R, Brobbey, P, Burrows, A, Elder, P, Ganyani, R, Horseman, C, Hurst, P, Mann, H, Marimuthu, K, McBride, S, Pilsworth, E, Powers, N, Stanier, P, Innes, R, Kersey, T, Kopczynska, M, Langasco, N, Rajagopal, R, Atkins, B, Beasley, W, Lim, ZC, Gill, A, Ang, HL, Williams, H, Yogeswara, T, Carter, R, Fam, M, Fong, J, Latter, J, Long, M, Mackinnon, S, McKenzie, C, Osmanska, J, Raghuvir, V, Shafi, A, Tsang, K, Walker, L, Bountra, K, Coldicutt, O, Fletcher, D, Hudson, S, Iqbal, S, Bernal, TL, Martin, JWB, Moss-Lawton, F, Cardwell, A, Edgerton, K, Laws, J, Rai, A, Robinson, K, Waite, K, Ward, J, Youssef, H, Knight, C, Koo, PY, Lazarou, A, Stanger, S, Thorn, C, Triniman, MC, Botha, A, Boyles, L, Cumming, S, Deepak, S, Ezzat, A, Fowler, AJ, Gwozdz, AM, Hussain, SF, Khan, S, Li, H, Morrell, BL, Neville, J, 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Background Acute illness, existing co‐morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a

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http://hdl.handle.net/10044/1/66218

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Single-cell and bulk ICP-MS investigation of accumulation patterns of Pt-based metallodrugs in cisplatin-sensitive and -resistant cell models.

Autor: Lim SY; NUS Graduate School's Integrative Sciences & Engineering Programme (ISEP), National University of Singapore, University Hall, Tan Chin Tuan Wing, Singapore 119077, Singapore.; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore., Low ZE; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore., Tan RPW; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore., Lim ZC; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore., Ang WH; NUS Graduate School's Integrative Sciences & Engineering Programme (ISEP), National University of Singapore, University Hall, Tan Chin Tuan Wing, Singapore 119077, Singapore.; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore., Kubota T; Agilent Technologies Japan Ltd., 9-1 Takakura-machi, Hachioji-shi, Tokyo 192-8510, Japan., Yamanaka M; Agilent Technologies Japan Ltd., 9-1 Takakura-machi, Hachioji-shi, Tokyo 192-8510, Japan., Pang S; Agilent Technologies Singapore Pte. Ltd., Singapore768923, Singapore., Simsek E; Agilent Technologies Singapore Pte. Ltd., Singapore768923, Singapore., Li SFY; NUS Graduate School's Integrative Sciences & Engineering Programme (ISEP), National University of Singapore, University Hall, Tan Chin Tuan Wing, Singapore 119077, Singapore.; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore.

Publikováno v: Metallomics : integrated biometal science [Metallomics] 2022 Dec 12; Vol. 14 (12).

Safety and effectiveness of switching to Abacavir/Lamivudine plus rilpivirine for maintenance therapy in virologically suppressed HIV-1 individuals in Singapore (SEALS).

Autor: Lim ZC; Department of Pharmacy, Ng Teng Fong General Hospital, Singapore, Singapore., Hoo GS; Department of Pharmacy, National Centre of Infectious Diseases, Singapore, Singapore. grace_sr_hoo@ttsh.com.sg.; Department of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore. grace_sr_hoo@ttsh.com.sg., Ang JH; Department of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore., Teng CB; Department of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore.; Department of Pharmacy, National University of Singapore, Singapore, Singapore., Ang LW; National Public Health and Epidemiology Unit, National Centre for Infectious Diseases, Singapore, Singapore., Lee CC; National Centre for Infectious Diseases, Singapore, Singapore.; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Leo YS; National Centre for Infectious Diseases, Singapore, Singapore.; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Law HL; Department of Pharmacy, National Centre of Infectious Diseases, Singapore, Singapore.; Department of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Ng OT; National Centre for Infectious Diseases, Singapore, Singapore.; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Wong CS; National Centre for Infectious Diseases, Singapore, Singapore.; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Publikováno v: AIDS research and therapy [AIDS Res Ther] 2021 Nov 01; Vol. 18 (1), pp. 80. Date of Electronic Publication: 2021 Nov 01.

Interfering with Metabolic Profile of Triple-Negative Breast Cancers Using Rationally Designed Metformin Prodrugs.

Autor: Babak MV; Drug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, 999077, Hong Kong SAR, P. R. China., Chong KR; Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543, Singapore, Singapore., Rapta P; Institute of Physical Chemistry and Chemistry Physics, Slovak Technical University of Technology, Radlinského 9, 82137, Bratislava, Slovak Republic., Zannikou M; Department of Neurological Surgery, The Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Tang HM; Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543, Singapore, Singapore., Reichert L; Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543, Singapore, Singapore., Chang MR; Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543, Singapore, Singapore., Kushnarev V; FSBI 'National Medical Research Center of Oncology, named after N.N Petrov', Ministry of Healthcare of the Russian Federation, 68 Leningradskaya Street, Pesochny, 197758, St Petersburg, Russian Federation., Heffeter P; Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria., Meier-Menches SM; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria., Lim ZC; Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543, Singapore, Singapore., Yap JY; Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543, Singapore, Singapore., Casini A; Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748, Garching, München, Germany., Balyasnikova IV; Department of Neurological Surgery, The Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Ang WH; Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543, Singapore, Singapore.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Jun 07; Vol. 60 (24), pp. 13405-13413. Date of Electronic Publication: 2021 May 06.