Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities.

Autor: Ho TLF; Disease Intervention Technology Lab (DITL), Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Lee MY; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Goh HC; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Ng GYN; Singapore Institute of Technology, Singapore, Singapore., Lee JJH; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Kannan S; Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lim YT; Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; SingMass - National Mass Spectrometry Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Zhao T; Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; SingMass - National Mass Spectrometry Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lim EKH; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Phua CZJ; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lee YF; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lim RYX; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ng PJH; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Yuan J; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chan DKH; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.; Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore., Lieske B; Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chong CS; Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lee KC; Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore., Lum J; Department of Pathology, National University Health System, Singapore, Singapore., Cheong WK; Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore., Yeoh KG; University Surgical Cluster, National University Health System, Singapore, Singapore., Tan KK; Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Sobota RM; Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; SingMass - National Mass Spectrometry Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Verma CS; Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; School of Biological Science, Nanyang Technological University, Singapore, Singapore.; Department of Biological Science, National University of Singapore, Singapore, Singapore., Lane DP; Disease Intervention Technology Lab (DITL), Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore, Singapore., Tam WL; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; School of Biological Science, Nanyang Technological University, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Venkitaraman AR; Disease Intervention Technology Lab (DITL), Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore, Singapore. arv22@nus.edu.sg.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. arv22@nus.edu.sg.; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. arv22@nus.edu.sg.

Publikováno v: Nature communications [Nat Commun] 2023 Mar 28; Vol. 14 (1), pp. 1726. Date of Electronic Publication: 2023 Mar 28.