ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response.

Autor: Lim LQJ; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Adler L; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Hajaj E; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Medicine D, Beilinson Hospital, Petah Tikva, Israel., Soria LR; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy., Perry RB; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Darzi N; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Brody R; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Furth N; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Lichtenstein M; Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Bab-Dinitz E; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Porat Z; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Melman T; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Brandis A; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Malitsky S; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Itkin M; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Aylon Y; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Ben-Dor S; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Orr I; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Pri-Or A; The De Botton Protein Profiling Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel., Seger R; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Shaul Y; Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Ruppin E; Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA., Oren M; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Perez M; Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA., Meier J; Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA., Brunetti-Pierri N; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.; Department of Translational Medicine, Medical Genetics, University of Naples Federico II, Naples, Italy.; Scuola Superiore Meridionale (SSM, School of Advanced Studies), Genomics and Experimental Medicine Program, University of Naples Federico II, Naples, Italy., Shema E; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Ulitsky I; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Erez A; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. ayelet.erez@weizmann.ac.il.

Publikováno v: Nature metabolism [Nat Metab] 2024 Jul; Vol. 6 (7), pp. 1294-1309. Date of Electronic Publication: 2024 Jun 10.

Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors.

Autor: Keshet R; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.; The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel., Lee JS; Cancer Data Science Lab, National Cancer Institutes of Health, Bethesda, MD, USA.; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Samsung Medical Center, Sungkyunkwan University, Seoul, Republic of Korea.; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea., Adler L; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Iraqi M; Faculty of Health Sciences, The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Beer Sheva, Israel., Ariav Y; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Lim LQJ; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Lerner S; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Rabinovich S; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Oren R; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel., Katzir R; Cancer Data Science Lab, National Cancer Institutes of Health, Bethesda, MD, USA., Weiss Tishler H; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Stettner N; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel., Goldman O; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Landesman H; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Galai S; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Kuperman Y; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel., Kuznetsov Y; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel., Brandis A; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Mehlman T; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Malitsky S; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Itkin M; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Koehler SE; Department Anatomy & Embryology, Maastricht University, Maastricht, the Netherlands., Zhao Y; Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Talsania K; Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Shen TW; Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Peled N; The Legacy Heritage Oncology Center and Dr. Larry Norton Institute, Soroka Medical Center and Ben-Gurion University, Beer-Sheva, Israel., Ulitsky I; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Porgador A; Faculty of Health Sciences, The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Beer Sheva, Israel., Ruppin E; Cancer Data Science Lab, National Cancer Institutes of Health, Bethesda, MD, USA. eyruppin@gmail.com., Erez A; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel. ayelet.erez@weizmann.ac.il.

Publikováno v: Nature cancer [Nat Cancer] 2020 Sep; Vol. 1 (9), pp. 894-908. Date of Electronic Publication: 2020 Aug 31.