Zobrazeno 1 - 10
of 552
pro vyhledávání: '"Lily-Yeh Jan"'
Autor:
Hugues Petitjean, Sophie Anne Pawlowski, Steven Li Fraine, Behrang Sharif, Doulia Hamad, Tarheen Fatima, Jim Berg, Claire M. Brown, Lily-Yeh Jan, Alfredo Ribeiro-da-Silva, Joao M. Braz, Allan I. Basbaum, Reza Sharif-Naeini
Publikováno v:
Cell Reports, Vol 13, Iss 6, Pp 1246-1257 (2015)
Neuropathic pain is a chronic debilitating disease that results from nerve damage, persists long after the injury has subsided, and is characterized by spontaneous pain and mechanical hypersensitivity. Although loss of inhibitory tone in the dorsal h
Externí odkaz:
https://doaj.org/article/7ba324e14c0d481c8a4aebb403525f60
Autor:
Shengjie Feng, Cristina Puchades, Juyeon Ko, Hao Wu, Yifei Chen, Eric E. Figueroa, Shuo Gu, Tina W. Han, Brandon Ho, Tong Cheng, Junrui Li, Brian Shoichet, Yuh Nung Jan, Yifan Cheng, Lily Yeh Jan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The dual functions of TMEM16F as Ca2+-activated ion channel and lipid scramblase raise intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA-approved drug niclosamide to inhibit TMEM16F-dependent syncytia
Externí odkaz:
https://doaj.org/article/a4fddbb981434a378a8b8da76a4df0a8
Publikováno v:
eLife, Vol 11 (2022)
Sensory neurons enable animals to detect environmental changes and avoid harm. An intriguing open question concerns how the various attributes of sensory neurons arise in development. Drosophila melanogaster larvae undergo a behavioral transition by
Externí odkaz:
https://doaj.org/article/bb6fa6b9b23b49e18e9b5d2d3d5be7b6
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The endolysosomal pathway plays an important role in regulating protein and lipid sorting and degradation. Here, the authors show that TMEM16K, an endoplasmic reticulum lipid scramblase, forms ER-endosome contact sites where it regulates endosomal so
Externí odkaz:
https://doaj.org/article/e026443ef1f54cb589f59433ef9e4058
Autor:
Shan Meltzer, Joshua A. Bagley, Gerardo Lopez Perez, Caitlin E. O’Brien, Laura DeVault, Yanmeng Guo, Lily Yeh Jan, Yuh-Nung Jan
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 859-866 (2017)
Summary: Disruptions in lipid homeostasis have been observed in many neurodevelopmental disorders that are associated with dendrite morphogenesis defects. However, the molecular mechanisms of how lipid homeostasis affects dendrite morphogenesis are u
Externí odkaz:
https://doaj.org/article/d901711a896c4637ab29b66523841162
Autor:
Samuel T. Slocum, Yongfeng Liu, Bryan L. Roth, Jian Jin, Brian E. Krumm, Brian J. Bender, Reid H.J. Olsen, Hye Jin Kang, Justin G. English, Isha Singh, Jing Liu, Lily Yeh Jan, Wenlei Ye, Brian K. Shoichet, Xi Ping Huang, Byron W. Hayes, Can Cao, John D. McCorvy, Jonathan F. Fay, Katherine Lansu, Soman N. Abraham, Shicheng Zhang, Chengwei Zhang, Wesley K. Kroeze, Kuglae Kim, He Chen, Ryan H. Gumpper, Jeffrey F. DiBerto, Joel Karpiak
Publikováno v:
Nature
Nature, vol 600, iss 7887
Nature, vol 600, iss 7887
The MRGPRX family of receptors (MRGPRX1–4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently1. Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-m
Publikováno v:
The Journal of cell biology, vol 222, iss 1
Membrane trafficking is essential for sculpting neuronal morphology. The GARP and EARP complexes are conserved tethers that regulate vesicle trafficking in the secretory and endolysosomal pathways, respectively. Both complexes contain the Vps51, Vps5
Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes
Publikováno v:
Molecular cell, vol 82, iss 13
The voltage-gated ion channel activity depends on both activation (transition from the resting state to the open state) and inactivation. Inactivation is a self-restraint mechanism to limit ion conduction and is as crucial to membrane excitability as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0fe105c07ee874ae8842dff939cd79
https://escholarship.org/uc/item/0tj7f6hp
https://escholarship.org/uc/item/0tj7f6hp
Publikováno v:
Annual review of neuroscience, vol 43, iss 1
Activation of mechanosensitive ion channels underlies a variety of fundamental physiological processes that require sensation of mechanical force. Different mechanosensitive channels adapt distinctive structures and mechanotransduction mechanisms to