Výsledky vyhledávání - "Lily Y. J. Zhang"

Akademický článek

Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease

Autor: Amy I. Smith-Dijak, Wissam B. Nassrallah, Lily Y. J. Zhang, Michal Geva, Michael R. Hayden, Lynn A. Raymond

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)

Huntington disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the huntingtin gene. The onset of symptoms is preceded by synaptic dysfunction. Homeostatic synaptic plasticity (HSP) refers to processes that maintain the sta

Externí odkaz: https://doaj.org/article/e96ca48365e947b3aff8e9ccdb535974

Zobrazit plný text záznamu

Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model

Autor: Jing Fan, Edward H. Y. Li, Clare M. Gladding, Liang Wang, Lily Y. J. Zhang, Paul J. Lombroso, Jian Xu, Lynn A. Raymond

Publikováno v: Journal of Neurochemistry. 130:145-159

Striatal neurodegeneration and synaptic dysfunction in Huntington's disease are mediated by the mutant huntingtin (mHtt) protein. MHtt disrupts calcium homeostasis and facilitates excitotoxicity, in part by altering NMDA receptor (NMDAR) trafficking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6df7ceb95e570cfb8d58e6f8cacaf34
https://doi.org/10.1111/jnc.12700

Zobrazit plný text záznamu

Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice

Autor: Ainsley Coquinco, Max S. Cynader, Marja D. Sepers, Lynn A. Raymond, Liang Wang, Clare M. Gladding, Lily Y. J. Zhang, Jing Fan, Alexandra M. Kaufman, Austen J. Milnerwood, Hwan Lee, Joy Yi Qiao, Yu Tian Wang

Publikováno v: Neurobiology of Disease, Vol 48, Iss 1, Pp 40-51 (2012)

We recently reported evidence for disturbed synaptic versus extrasynaptic NMDAR transmission in the early pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder caused by CAG repeat expansion in the gene encoding huntingti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d888f24b683961793d14ccbcd9abed1
http://www.sciencedirect.com/science/article/pii/S0969996112001994

Zobrazit plný text záznamu

Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model

Autor: Austen J. Milnerwood, Clare M. Gladding, Jian Xu, Lily Y. J. Zhang, Paul J. Lombroso, Marja D. Sepers, Lynn A. Raymond

Publikováno v: Human Molecular Genetics. 21:3739-3752

In Huntington's disease (HD), the mutant huntingtin (mhtt) protein is associated with striatal dysfunction and degeneration. Excitotoxicity and early synaptic defects are attributed, in part, to altered NMDA receptor (NMDAR) trafficking and function.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5618408b7ba09d57adca5f892bafede
https://doi.org/10.1093/hmg/dds154

Zobrazit plný text záznamu

P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease

Autor: Lynn A. Raymond, Liang Wang, Alexandra M. Kaufman, Lily Y. J. Zhang, Jing Fan, Clare M. Gladding, Austen J. Milnerwood

Publikováno v: Neurobiology of Disease, Vol 45, Iss 3, Pp 999-1009 (2012)

Huntington disease (HD) is a dominantly inherited neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the protein huntingtin (htt). Previous studies have shown enhanced N-methyl-d-aspartate (NMDA)-induced excitotoxicity in neuron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da511b9629beaa3ef1dbd6b761be727
http://www.sciencedirect.com/science/article/pii/S0969996111003949

Zobrazit plný text záznamu

N-Methyl-d-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95

Autor: Lily Y. J. Zhang, Ashley A. George, Liang Wang, Jing Fan, Lynn A. Raymond, Oana Cristina Vasuta

Publikováno v: Journal of Neurochemistry. 115:1045-1056

NMDA receptors (NMDARs) mediate excitatory synaptic transmission during repetitive or prolonged glutamate release, playing a critical role in synaptic plasticity or cell death, respectively. Evidence indicates that a major pathway of NMDAR signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::722fcc078b81794be54810ffec0148bf
https://doi.org/10.1111/j.1471-4159.2010.06994.x

Zobrazit plný text záznamu

Interaction of Postsynaptic Density Protein-95 with NMDA Receptors Influences Excitotoxicity in the Yeast Artificial Chromosome Mouse Model of Huntington's Disease

Autor: Lynn A. Raymond, Michael R. Hayden, Catherine M. Cowan, Jing Fan, Lily Y. J. Zhang

Publikováno v: The Journal of Neuroscience. 29:10928-10938

Evidence suggests that NMDA-type glutamate receptors contribute to degeneration of striatal medium-sized spiny neurons (MSNs) in Huntington's disease (HD). Previously, we demonstrated that NMDA receptor (NMDAR)-mediated current and/or toxicity is inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d6c6369a49e6a8a8a8fd13171aab35
https://doi.org/10.1523/jneurosci.2491-09.2009

Zobrazit plný text záznamu

NMDA Receptor Desensitization Regulated by Direct Binding to PDZ1-2 Domains of PSD-95

Autor: Alaa El-Husseini, Oana Cristina Vasuta, Bo Li, Christine Sutton, Lynn A. Raymond, Lily Y. J. Zhang, Lavan Sornarajah

Publikováno v: Journal of Neurophysiology. 99:3052-3062

Regulation of N-methyl-d-aspartate receptor (NMDAR) activity by desensitization is important in physiological and pathological states; NMDAR desensitization contributes in shaping synaptic responses and may be protective by limiting calcium influx du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ab7d08f547e1e8b803937097ebb1ae
https://doi.org/10.1152/jn.90301.2008

Zobrazit plný text záznamu

N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95

Autor: Jing, Fan, Oana Cristina, Vasuta, Lily Y J, Zhang, Liang, Wang, Ashley, George, Lynn A, Raymond

Publikováno v: Journal of neurochemistry. 115(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::215c49ab2dbc5f0eb297b2331445bd91
https://pubmed.ncbi.nlm.nih.gov/20831617

Zobrazit plný text záznamu

Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity

Autor: Mannie M Y Fan, Lily Y. J. Zhang, Lynn A. Raymond, Catherine M. Cowan, Michael R. Hayden, Jacqueline Shehadeh, Rona K. Graham, Jing Fan

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(48)

Huntington disease (HD), caused by CAG expansion in the ubiquitously expressed huntingtin gene, is characterized by early dysfunction and death of striatal medium-sized spiny neurons (MSNs). Previous work has shown MSN-specific alterations in NMDA re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a564cc43a8fc94c3e2a6d3680497a3e3
https://pubmed.ncbi.nlm.nih.gov/19036965

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání