Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Lily W. Hu"'
Autor:
Shirley Q. Feng, Lily W. Hu, Hanbiao Yang, Mohanram Sivaraja, Russell Johnson, Robert S. McDowell, Haiying Cai, Julie Lai, Yuko Kosaka, Marc J. Evanchik, Cristiana A. Zaharia, Johan D. Oslob, Samnang Tep
Publikováno v:
ACS Medicinal Chemistry Letters. 4:113-117
Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochemical activities. The most potent analogue (compound 19) also inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfbfcaac97a11e0feb783bd78931ba6
https://doi.org/10.1021/ml300335r
https://doi.org/10.1021/ml300335r
Autor:
Douglas Buckley, Timothy S. Heuer, Allan S. Wagman, Richard Benn Abegania Ventura, Lily W. Hu, Russell Johnson, Kasia Mordec, Julie Lai, Joanna Waszczuk, George Kemble, Marie O'Farrell, Marina Fridlib, Glenn Hammonds
Publikováno v:
Cancer Research. 75:4446-4446
Inhibition of de novo palmitate synthesis by fatty acid synthase (FASN) is a novel cancer therapeutic approach with strong biological rationale. Tumor cells have an increased dependence on FASN-synthesized palmitate compared to non-tumor cells, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dc706c6d42468d7eb4142e02b9bc14c
https://doi.org/10.1158/1538-7445.am2015-4446
https://doi.org/10.1158/1538-7445.am2015-4446