Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lily M. Blair"'
Autor:
Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the interactions between oncogenes and tumor suppressor genes that shape this landscape remain po
Externí odkaz:
https://doaj.org/article/d8b8fe0a0e6941c7a811944dff8fc5cc
Autor:
Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters
Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the features of this landscape remain poorly understood and cannot be revealed by human cancer genotyping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24eaf900600c609cefb81d012b1d1452
https://doi.org/10.1101/2022.10.24.511787
https://doi.org/10.1101/2022.10.24.511787
Autor:
Paul J. McMurdie, Ian P. Winters, Lily M. Blair, Lafia Sebastian, Vy Tran, Gabriel Grenot, Edwin A. Apilado, Ian K. Lai, Gregory D. Wall, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Joseph Juan
Publikováno v:
Cancer Research. 83:2789-2789
Cancer is characterized by diverse genomic alterations that change cell state and can modify therapy responses. In some cases, the relationships between genotype and drug responses are obvious, such as the response of tumors with defined oncogenic mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa40adf2377579e78ebee94007dfb388
https://doi.org/10.1158/1538-7445.am2023-2789
https://doi.org/10.1158/1538-7445.am2023-2789
Autor:
Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters
Publikováno v:
Cancer Research. 83:1172-1172
Cancer progression is a quintessential example of a walk on an adaptive fitness landscape, with tumor growth depending on the cooperation of multiple driver mutations. While sequencing of tens of thousands of clinical samples has revealed a vast set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::899b0222484a93558c8dafd1de6a0783
https://doi.org/10.1158/1538-7445.am2023-1172
https://doi.org/10.1158/1538-7445.am2023-1172
Elucidation of hepatitis C virus transmission and early diversification by single genome sequencing.
Autor:
Hui Li, Mark B Stoddard, Shuyi Wang, Lily M Blair, Elena E Giorgi, Erica H Parrish, Gerald H Learn, Peter Hraber, Paul A Goepfert, Michael S Saag, Thomas N Denny, Barton F Haynes, Beatrice H Hahn, Ruy M Ribeiro, Alan S Perelson, Bette T Korber, Tanmoy Bhattacharya, George M Shaw
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002880 (2012)
A precise molecular identification of transmitted hepatitis C virus (HCV) genomes could illuminate key aspects of transmission biology, immunopathogenesis and natural history. We used single genome sequencing of 2,922 half or quarter genomes from pla
Externí odkaz:
https://doaj.org/article/61aa16abca6545d5abf89b90a7f53ec3
Autor:
Katja Pfafferott, Tanmoy Bhattacharya, George M. Shaw, Yalu Chen, Gerald H. Learn, Katharine J. Bar, Lily M. Blair, Beatrice H. Hahn, Mina John, Hui Li, Simon Mallal
Publikováno v:
The Journal of Infectious Diseases. 208:1598-1603
Trials of human immunodeficiency virus type 1 (HIV) pre- and postexposure prophylaxis show promise. Here, we describe a novel strategy for deciphering mechanisms of prophylaxis failure that could improve therapeutic outcomes. A healthcare worker bega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f3055e1509259165f8ba94d9741a0fd
https://doi.org/10.1093/infdis/jit485
https://doi.org/10.1093/infdis/jit485
Autor:
Beatrice H. Hahn, Mark B. Stoddard, Daniel S. Fierer, Hui Li, Tanmoy Bhattacharya, Harvey J. Alter, George M. Shaw, Gerald H. Learn, Shuyi Wang, Ruy M. Ribeiro, Alan S. Perelson, Lily M. Blair, Elena E. Giorgi, Michael P. Busch
Publikováno v:
Journal of Virology
Despite the recent development of highly effective anti-hepatitis C virus (HCV) drugs, the global burden of this pathogen remains immense. Control or eradication of HCV will likely require the broad application of antiviral drugs and development of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb1a165d95ef30bafbc9a7426cbb63f
https://pubmed.ncbi.nlm.nih.gov/26468546
https://pubmed.ncbi.nlm.nih.gov/26468546
Autor:
Robin J. Shattock, Christiane Moog, Norman L. Letvin, Gary Landucci, Merlin L. Robb, Ryan Duffy, Georgia D. Tomaras, Elena E. Giorgi, Pinghuang Liu, Lily M. Blair, Guido Ferrari, Robert J. Schutte, Shi-Mao Xia, Supachai Rerks-Ngarm, M. A. Moody, Kelly A. Soderberg, S. Munir Alam, Nathan I. Nicely, Punnee Pitisuttithum, David C. Montefiori, Donald N. Forthal, Hui Li, Ruijun Zhang, Jerome H. Kim, Andrew Chao, Ranjit Warrier, Bette T. Korber, George M. Shaw, Amit Kumar, Nelson L. Michael, Sarah L. Cocklin, Kora Vidnovic, Hua-Xin Liao, Justin Pollara, James E. Robinson, Katja Klein, Jaranit Kaewkungwal, Charles W. Pemble, S. Moses Dennison, Joern E. Schmitz, Xiaoying Shen, Abbey Evans, Sorachai Nitayaphan, Feng Gao, Sampa Santra, Barton F. Haynes
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 11, Iss 8, p e1005042 (2015)
PLoS Pathogens, Vol 11, Iss 8, p e1005042 (2015)
HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies (bnAbs) are the type of HIV-1 antibodies that are most likely protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8534548eaf5d098f2604e39d18961d3f
https://pubmed.ncbi.nlm.nih.gov/26237403
https://pubmed.ncbi.nlm.nih.gov/26237403
Autor:
Lily M. Blair, Marcus W. Feldman
Publikováno v:
BMC Genetics
Background Demography and environmental adaptation can affect the global distribution of genetic variants and possibly the distribution of disease. Population heterozygosity of single nucleotide polymorphisms has been shown to decrease strongly with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df47e617aab5ef50c9cde35ccf6f1d20
https://pubmed.ncbi.nlm.nih.gov/26170196
https://pubmed.ncbi.nlm.nih.gov/26170196
Publikováno v:
Human Genomics
Background Phenotypic variation along environmental gradients has been documented among and within many species, and in some cases, genetic variation has been shown to be associated with these gradients. Bayenv is a relatively new method developed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d721b2ca796005ec7080f0b13871f2c
https://doi.org/10.1186/1479-7364-8-1
https://doi.org/10.1186/1479-7364-8-1