Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance.

Autor: Gherardi G; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Weiser A; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produit Nestlé S.A., EPFL Innovation Park, 1015 Lausanne, Switzerland; Molecular Nutritional Medicine, Else Kröner Fresenius Center for Nutritional Medicine, Technische Universität München, 85354 Freising, Germany., Bermont F; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produit Nestlé S.A., EPFL Innovation Park, 1015 Lausanne, Switzerland., Migliavacca E; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produit Nestlé S.A., EPFL Innovation Park, 1015 Lausanne, Switzerland., Brinon B; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produit Nestlé S.A., EPFL Innovation Park, 1015 Lausanne, Switzerland., Jacot GE; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produit Nestlé S.A., EPFL Innovation Park, 1015 Lausanne, Switzerland., Hermant A; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produit Nestlé S.A., EPFL Innovation Park, 1015 Lausanne, Switzerland., Sturlese M; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35131 Padova, Italy., Nogara L; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35131 Padova, Italy., Vascon F; Department of Biology, University of Padova, 35131 Padova, Italy., De Mario A; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Mattarei A; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35131 Padova, Italy., Garratt E; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK., Burton M; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK., Lillycrop K; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK; Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK., Godfrey KM; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK; Medical Research Council Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK., Cendron L; Department of Biology, University of Padova, 35131 Padova, Italy., Barron D; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produit Nestlé S.A., EPFL Innovation Park, 1015 Lausanne, Switzerland., Moro S; Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35131 Padova, Italy., Blaauw B; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy; Venetian Institute of Molecular Medicine (VIMM), Via Orus 2, 35129 Padova, Italy., Rizzuto R; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy; Myology Center (CIR-Myo), University of Padova, 35131 Padova, Italy. Electronic address: rosario.rizzuto@unipd.it., Feige JN; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produit Nestlé S.A., EPFL Innovation Park, 1015 Lausanne, Switzerland; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Electronic address: jerome.feige@rd.nestle.com., Mammucari C; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy; Myology Center (CIR-Myo), University of Padova, 35131 Padova, Italy. Electronic address: cristina.mammucari@unipd.it., De Marchi U; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produit Nestlé S.A., EPFL Innovation Park, 1015 Lausanne, Switzerland. Electronic address: umberto.demarchi@rd.nestle.com.

Publikováno v: Cell metabolism [Cell Metab] 2024 Nov 23. Date of Electronic Publication: 2024 Nov 23.

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Machine learning-based DNA methylation score for fetal exposure to maternal smoking:development and validation in samples collected from adolescents and adults

Autor: Rauschert, S. (Sebastian), Melton, P. E. (Phillip E.), Heiskala, A. (Anni), Karhunen, V. (Ville), Burdge, G. (Graham), Craig, J. M. (Jeffrey M.), Godfrey, K. M. (Keith M.), Lillycrop, K. (Karen), Mori, T. A. (Trevor A.), Beilin, L. J. (Lawrence J.), Oddy, W. H. (Wendy H.), Pennell, C. (Craig), Järvelin, M.-R. (Marjo-Riitta), Sebert, S. (Sylvain), Huang, R.-C. (Rae-Chi)

Background: Fetal exposure to maternal smoking during pregnancy is associated with the development of noncommunicable diseases in the offspring. Maternal smoking may induce such long-term effects through persistent changes in the DNA methylome, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::d110020789162fede3a061dbc46edc05
http://urn.fi/urn:nbn:fi-fe202102175154

Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function.

Autor: Titcombe P; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK., Murray R; Institute of Developmental Sciences, University of Southampton, Southampton, UK., Hewitt M; Institute of Developmental Sciences, University of Southampton, Southampton, UK., Antoun E; Institute of Developmental Sciences, University of Southampton, Southampton, UK.; Centre for Biological Sciences, University of Southampton, Southampton, UK., Cooper C; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK., Inskip HM; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Holbrook JD; Institute of Developmental Sciences, University of Southampton, Southampton, UK., Godfrey KM; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.; Institute of Developmental Sciences, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Lillycrop K; Institute of Developmental Sciences, University of Southampton, Southampton, UK.; Centre for Biological Sciences, University of Southampton, Southampton, UK., Hanson M; Institute of Developmental Sciences, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Barton SJ; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

Publikováno v: Epigenetics [Epigenetics] 2022 Jun; Vol. 17 (6), pp. 653-664. Date of Electronic Publication: 2021 Aug 30.