Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lilly M. Wong"'
Autor:
Yuyang Tang, Antoine Chaillon, Sara Gianella, Lilly M. Wong, Dajiang Li, Theresa L. Simermeyer, Magali Porrachia, Caroline Ignacio, Brendon Woodworth, Daniel Zhong, Jiayi Du, Eduardo de la Parra Polina, Jennifer Kirchherr, Brigitte Allard, Matthew L. Clohosey, Matt Moeser, Amy L. Sondgeroth, Gregory D. Whitehill, Vidisha Singh, Amir Dashti, Davey M. Smith, Joseph J. Eron, Katherine J. Bar, Ann Chahroudi, Sarah B. Joseph, Nancie M. Archin, David M. Margolis, Guochun Jiang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Brain microglia (MG) may serve as a human immunodeficiency virus 1 (HIV) reservoir and ignite rebound viremia following cessation of antiretroviral therapy (ART), but they have yet to be proven to harbor replication-competent HIV. Here, we isolated b
Externí odkaz:
https://doaj.org/article/2b445d2797e54b559239027e8348ce19
Autor:
Dajiang Li, Lilly M. Wong, Yuyang Tang, Brigitte Allard, Katherine S. James, George R. Thompson, Satya Dandekar, Edward P. Browne, Qingsheng Li, Jeremy M. Simon, Nancie M. Archin, David M. Margolis, Guochun Jiang
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105743- (2023)
Summary: HIV reservoirs are extremely stable and pose a tremendous challenge to clear HIV infection. Here, we demonstrate that activation of ISR/ATF4 signaling reverses HIV latency, which also selectively eliminates HIV+ cells in primary CD4+ T cell
Externí odkaz:
https://doaj.org/article/4754676d264e4d7cbf4fe632cfa2482d
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/4e5067557b6d4430a78d3aa4e548ea6f
Autor:
Sahil Shah, Lilly M. Wong, Kendra Ellis, Brittany Bodnar, Sami Saribas, Julia Ting, Zhengyu Wei, Yuyang Tang, Xianwei Wang, Hong Wang, Binhua Ling, David M. Margolis, J. Victor Garcia, Wenhui Hu, Guochun Jiang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Adeno-associated virus (AAV)-mediated genetic targeting of microglia remains a challenge. Overcoming this hurdle is essential for gene editing in the central nervous system (CNS). Here, we characterized the minimal/native promoter of the HEXB gene, w
Externí odkaz:
https://doaj.org/article/54a2bdcd07e54840b12bb705d5db3997
Autor:
Lilly M. Wong, Dajiang Li, Yuyang Tang, Gema Méndez-Lagares, George R. Thompson, Dennis J. Hartigan-O’Connor, Satya Dandekar, Guochun Jiang
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Human Immunodeficiency Virus-1 (HIV) remains a global health challenge due to the latent HIV reservoirs in people living with HIV (PLWH). Dormant yet replication competent HIV harbored in the resting CD4+ T cells cannot be purged by antiretroviral th
Externí odkaz:
https://doaj.org/article/4ec20ff6d745410797a51aa2ffcf6e3a
Autor:
Dajiang Li, Morgan G. Dewey, Li Wang, Shane D. Falcinelli, Lilly M. Wong, Yuyang Tang, Edward P. Browne, Xian Chen, Nancie M. Archin, David M. Margolis, Guochun Jiang
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103649- (2022)
Summary: The eradication of HIV infection is difficult to achieve because of stable viral reservoirs. Here, we show that crotonylation enhances AZD5582-induced noncanonical NF-κB (ncNF-κB) signaling, further augmenting HIV latency reversal in Jurka
Externí odkaz:
https://doaj.org/article/40baf72d802e42f5b3fd5261a4846a4b
Autor:
Lilly M. Wong, Guochun Jiang
Publikováno v:
EBioMedicine, Vol 63, Iss , Pp 103159- (2021)
HIV cure is thwarted by the presence of quiescent yet replication competent HIV-1 (HIV). Antiretroviral therapy (ART) is unable to eradicate reservoirs, and upon cessation of ART, HIV will rebound. This review encompasses the curative strategies of H
Externí odkaz:
https://doaj.org/article/0d67eabb2b4c4a09a15f3290d1346fc4
Autor:
Lilly M. Wong, Guochun Jiang
Publikováno v:
Pathogens, Vol 10, Iss 11, p 1378 (2021)
The COVID-19 pandemic continues around the world, where the United States is among the worst in terms of both morbidity and fatality of the viral infection. We aim to investigate the plausible link of tissue SARS-CoV-2 viral entry gene expression, su
Externí odkaz:
https://doaj.org/article/efa6cc0e0dba4bbd8339b5cae50d0d96
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-4 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The current coronavirus disease 2019 (COVID-19) pandemic presents a global public health challenge. The viral pathogen responsible, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), binds to the host receptor ACE2 through its spike (S) gl
Autor:
Guochun Jiang, Dajiang Li, Shane D. Falcinelli, Lilly M. Wong, Yuyang Tang, Edward P. Browne, Nancie M. Archin, David M. Margolis
Publikováno v:
The FASEB Journal. 36