New insights into the regulation by RUNX1 and GFI1(s) proteins of the endothelial to hematopoietic transition generating primordial hematopoietic cells

Autor: Thambyrajah, Roshana, Patel, Rahima, Mazan, Milena, Lie-A-Ling, Michael, Lilly, Andrew J, Eliades, Alexia, Menegatti, Sara, Garcia Alegria, Eva, Florkowska, Magdalena, Batta, Kiran, Kouskoff, Valerie, Lacaud, Georges

Publikováno v: Cell Cycle
Thambyrajah, R, Patel, R, Mazan, M, Lie-A-Ling, M, Lilly, A J, Eliades, A, Menegatti, S, Garcia Alegria, E, Florkowska, M, Batta, K, Kouskoff, V & Lacaud, G 2016, ' New insights into the regulation by RUNX1 and GFi1(s) proteins of the endothelial to hematopoietic transition generating primordial hematopoietic cells ', Cell Cycle, vol. 15, no. 16, pp. 2108-2114 . https://doi.org/10.1080/15384101.2016.1203491

The first hematopoietic cells are generated very early in ontogeny to support the growth of the embryo and to provide the foundation to the adult hematopoietic system. There is a considerable therapeutic interest in understanding how these first bloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c4bdb68d0068586299fb2306897c7eae
http://europepmc.org/articles/PMC4993433

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation

Autor: Goode, Debbie K., Obier, Nadine, Vijayabaskar, M.S., Lie-A-Ling, Michael, Lilly, Andrew J., Hannah, Rebecca, Lichtinger, Monika, Batta, Kiran, Florkowska, Magdalena, Patel, Rahima, Challinor, Mairi, Wallace, Kirstie, Gilmour, Jane, Assi, Salam A., Cauchy, Pierre, Hoogenkamp, Maarten, Westhead, David R., Lacaud, Georges, Kouskoff, Valerie, Göttgens, Berthold, Bonifer, Constanze

Publikováno v: Developmental Cell
Goode, D K, Obier, N, Vijayabaskar, M S, Lie-A-Ling, M, Lilly, A, Hannah, R, Lichtinger, M, Batta, K, Florkowska, M, Patel, R, Challinor, M, Wallace, K, Gilmour, J, Assi, S A, Cauchy, P, Hoogenkamp, M, Westhead, D R, Lacaud, G, Kouskoff, V, Göttgens, B & Bonifer, C 2016, ' Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation ', Developmental cell, vol. 36, no. 5, pp. 572-587 . https://doi.org/10.1016/j.devcel.2016.01.024

Summary Metazoan development involves the successive activation and silencing of specific gene expression programs and is driven by tissue-specific transcription factors programming the chromatin landscape. To understand how this process executes an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a0882ce8c4a37ab14b23d247967f9e08
https://eprints.whiterose.ac.uk/96518/8/1-s2.0-S1534580716300028-main.pdf

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The haematopoietic stem cell niche:new insights into the mechanisms regulating haematopoietic stem cell behaviour

Autor: Lilly, Andrew J., Johnson, William E., Bunce, Christopher M.

The concept of the haematopoietic stem cell (HSC) niche was formulated by Schofield in the 1970s, as a region within the bone marrow containing functional cell types that can maintain HSC potency throughout life. Since then, ongoing research has iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::575205958301320ea5cd7c085dbf5589
https://publications.aston.ac.uk/id/eprint/16486/1/The_Haematopoietic_StemCell_Niche.pdf