Výsledky vyhledávání - "Lillie Leach"

Abstract 3190: ALA-CART induces global transcriptional changes leading to enhanced potency and persistence of CAR T cells against both lymphoid and myeloid acute leukemias

Autor: Catherine Danis, Lillie Leach, Christopher Ebmeier, Amanda Novak, Etienne Danis, M. Eric Kohler

Publikováno v: Cancer Research. 83:3190-3190

Chimeric antigen receptor (CAR) T cell therapy has revolutionized cancer treatment, demonstrating clinical success in B-cell malignancies that are refractory to standard therapies. Relapses after CAR therapy has demonstrated the limitations of curren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8401f85596b44dd97c5cccc46768a5ff
https://doi.org/10.1158/1538-7445.am2023-3190

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IMMU-23. Novel gene-edited CAR-T cell therapy against Diffuse Intrinsic Pontine Glioma

Autor: Ilango Balakrishnan, Lillie Leach, Senthilnath Lakshmanachetty, Angela Pierce, Krishna Madhavan, Hannah Chatwin, Susan Fosmire, Christina Meadows, Adam Green, Terry Fry, Rajeev Vibhakar, Eric M Kohler, Sujatha Venkataraman

Publikováno v: Neuro-Oncology. 24:i86-i87

BACKGROUND: We identified high expression of CD99 in DIPG tumors and developed a CAR using our newly identified single chain variable fragment (scFv) targeting CD99 incorporating a 4-1BB co-stimulatory domain. This CD99 CAR demonstrated the ability t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caead7518f71002f886c3431794e7dd5
https://doi.org/10.1093/neuonc/noac079.316

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Abstract 3607: A novel adjunctive LAT-activating CAR T (ALA-CART) cell platform demonstrates enhanced antigen sensitivity and eradication of antigen-low leukemia

Autor: Catherine Pham-Danis, Lillie Leach, Christopher Ebmeier, M. Eric Kohler

Publikováno v: Cancer Research. 82:3607-3607

CAR T cells have demonstrated clinical success in malignancies that are refractory to standard therapies; however, preclinical and clinical studies have demonstrated that CAR T cell efficacy is greatly reduced in settings of low levels of target anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::060cefabb854cf91c7496726475327e2
https://doi.org/10.1158/1538-7445.am2022-3607

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Multi-Modal Targeting of FLT3 with Chimeric Antigen Receptor T Cell Immunotherapy and Tyrosine Kinase Inhibition in High-Risk Pediatric Leukemias

Autor: Zachary Graff, Lillie Leach, Asen Bagashev, Sarah K. Tasian, Lisa M Niswander, Terry J. Fry

Publikováno v: Blood. 138:404-404

Background: Clinical outcomes for children with FLT3-mutant AML and infants with KMT2A-rearranged (KMT2A-R) B-ALL remain dismal. These leukemias share a common feature of aberrant activation of FLT3 kinase signaling, which occurs by activating FLT3 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bee8f24db1827680d76302c017f47c62
https://doi.org/10.1182/blood-2021-147321

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