Pirfenidone Is a Vasodilator: Involvement of KV7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice

Autor: Lilliana Beck, Estéfano Pinilla, Daniel Dias Rufino Arcanjo, Raquel Hernanz, Judit Prat-Duran, Asbjørn Graver Petersen, Ralf Köhler, Majid Sheykhzade, Simon Comerma-Steffensen, Ulf Simonsen

Publikováno v: Frontiers in Pharmacology, Vol 11 (2021)

Endothelial cell dysfunction and fibrosis are associated with worsening of the prognosis in patients with cardiovascular disease. Pirfenidone has a direct antifibrotic effect, but vasodilatation may also contribute to the effects of pirfenidone. Ther

Externí odkaz: https://doaj.org/article/34134b1c93264b05a5e166de31839f1e

Pirfenidone Is a Vasodilator: Involvement of KV7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice

Autor: Daniel Dias Rufino Arcanjo, Majid Sheykhzade, Raquel Hernanz, Ralf Köhler, Simon Comerma-Steffensen, Judit Prat-Duran, Ulf Simonsen, Estéfano Pinilla, Lilliana Beck, Asbjørn Graver Petersen

Publikováno v: Thinggaard, L B, Pinilla, E, Arcanjo, D D R, Hernanz, R, Prat Duran, J, Petersen, A, Köhler, R, Sheykhzade, M, Comerma Steffensen, S G & Simonsen, U 2021, ' Pirfenidone Is a Vasodilator: Involvement of KV7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice ', Frontiers in Pharmacology, vol. 11, 619152 . https://doi.org/10.3389/fphar.2020.619152
Frontiers in Pharmacology, Vol 11 (2021)
Beck, L, Pinilla, E, Arcanjo, D D R, Hernanz, R, Prat-Duran, J, Petersen, A G, Köhler, R, Sheykhzade, M, Comerma-Steffensen, S & Simonsen, U 2021, ' Pirfenidone Is a Vasodilator : Involvement of K V 7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice ', Frontiers in Pharmacology, vol. 11, 619152 . https://doi.org/10.3389/fphar.2020.619152

Endothelial cell dysfunction and fibrosis are associated with worsening of the prognosis in patients with cardiovascular disease. Pirfenidone has a direct antifibrotic effect, but vasodilatation may also contribute to the effects of pirfenidone. Ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66abadbf891e3684b677a37e10c10a52
https://pure.au.dk/portal/da/publications/pirfenidone-is-a-vasodilator-involvement-of-kv7-channels-in-the-effect-on-endotheliumdependent-vasodilatation-in-type2-diabetic-mice(67bad165-322a-4e7b-af9b-19aeda4dd175).html

Endothelial Dysfunction and Passive Changes in the Aorta and Coronary Arteries of Diabetic db/db Mice

Autor: Rune Carlsson, Lilliana Beck, Estéfano Pinilla, Carl Christian Danielsen, Ulf Simonsen, Majid Sheykhzade, Raquel Hernanz, Simon Comerma-Steffensen, Junjing Su

Publikováno v: Frontiers in Physiology, Vol 11 (2020)
Frontiers in Physiology
Thinggaard, L B, Su, J, Comerma Steffensen, S G, Pinilla, E, Carlsson, R F, Hernanz, R, Sheykhzade, M, Danielsen, C C & Simonsen, U 2020, ' Endothelial Dysfunction and Passive Changes in the Aorta and Coronary Arteries of Diabetic db/db Mice ', Frontiers in Physiology, bind 11, 667 . https://doi.org/10.3389/fphys.2020.00667
Beck, L, Su, J, Comerma-Steffensen, S, Pinilla, E, Carlsson, R, Hernanz, R, Sheykhzade, M, Danielsen, C C & Simonsen, U 2020, ' Endothelial Dysfunction and Passive Changes in the Aorta and Coronary Arteries of Diabetic db/db Mice ', Frontiers in Physiology, vol. 11, 667 . https://doi.org/10.3389/fphys.2020.00667

Endothelial cell dysfunction and vessel stiffening are associated with a worsened prognosis in diabetic patients with cardiovascular diseases. The present study hypothesized that sex impacts endothelial dysfunction and structural changes in arteries

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208b974ab95bf6733633a5a4737cdcc7

Involvement of K Ca 2.3 Channels in Relaxation of Erectile Tissue is Altered in Type 2 Diabetic Mice

Autor: Rafael Sobrano Fais, Susie Mogensen, Simon Gabriel Comerma Steffensen, Lilliana Beck, Ulf Simonsen

Publikováno v: The FASEB Journal. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc7b2b9bc27df22872035e91df14adf0
https://doi.org/10.1096/fasebj.2019.33.1_supplement.512.7

Novel selective phosphodiesterase type 1 inhibitors cause vasodilatation and lower blood pressure in rats

Autor: Laursen, Morten, Thinggaard, Lilliana Beck, Kehler, Jan, Christoffersen, Claus Tornby, Bundgaard, Christoffer, Mogensen, Susie, Mow, Tomas, Pinilla, Estéfano, Knudsen, Jakob Schöllhammer, Hedegaard, Elise Røge, Grunnet, Morten, Simonsen, Ulf

Publikováno v: Laursen, M, Thinggaard, L B, Kehler, J, Christoffersen, C T, Bundgaard, C, Mogensen, S, Mow, T, Pinilla, E, Knudsen, J S, Hedegaard, E R, Grunnet, M & Simonsen, U 2017, ' Novel selective phosphodiesterase type 1 inhibitors cause vasodilatation and lower blood pressure in rats ', British Journal of Pharmacology, vol. 174, no. 15, pp. 2563-2575 . https://doi.org/10.1111/bph.13868

BACKGROUND AND PURPOSE: Phosphodiesterase enzymes (PDE1-11) break down cyclic nucleotides and are important in the regulation of the cardiovascular system. The purpose of the present study was to investigate the effect on the cardiovascular system of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::987aa396731dd4c1d2eb5dedd729156a
https://pure.au.dk/portal/da/publications/novel-selective-phosphodiesterase-type-1-inhibitors-cause-vasodilatation-and-lower-blood-pressure-in-rats(8b3cc7ed-bb97-4cb6-afb7-9f10894055d2).html