Divergent landscapes of A-to-I editing in postmortem and living human brain

Autor: Miguel Rodriguez de los Santos, Brian H. Kopell, Ariela Buxbaum Grice, Gauri Ganesh, Andy Yang, Pardis Amini, Lora E. Liharska, Eric Vornholt, John F. Fullard, Pengfei Dong, Eric Park, Sarah Zipkowitz, Deepak A. Kaji, Ryan C. Thompson, Donjing Liu, You Jeong Park, Esther Cheng, Kimia Ziafat, Emily Moya, Brian Fennessy, Lillian Wilkins, Hannah Silk, Lisa M. Linares, Brendan Sullivan, Vanessa Cohen, Prashant Kota, Claudia Feng, Jessica S. Johnson, Marysia-Kolbe Rieder, Joseph Scarpa, Girish N. Nadkarni, Minghui Wang, Bin Zhang, Pamela Sklar, Noam D. Beckmann, Eric E. Schadt, Panos Roussos, Alexander W. Charney, Michael S. Breen

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA modification within the brain. Yet, most research has relied on postmortem samples, assuming it is an accurate representation of RNA biology in the living brain. W

Externí odkaz: https://doaj.org/article/da9c46017e36443fb5aa615c25a1975d

Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children

Autor: Noam D. Beckmann, Phillip H. Comella, Esther Cheng, Lauren Lepow, Aviva G. Beckmann, Scott R. Tyler, Konstantinos Mouskas, Nicole W. Simons, Gabriel E. Hoffman, Nancy J. Francoeur, Diane Marie Del Valle, Gurpawan Kang, Anh Do, Emily Moya, Lillian Wilkins, Jessica Le Berichel, Christie Chang, Robert Marvin, Sharlene Calorossi, Alona Lansky, Laura Walker, Nancy Yi, Alex Yu, Jonathan Chung, Matthew Hartnett, Melody Eaton, Sandra Hatem, Hajra Jamal, Alara Akyatan, Alexandra Tabachnikova, Lora E. Liharska, Liam Cotter, Brian Fennessy, Akhil Vaid, Guillermo Barturen, Hardik Shah, Ying-chih Wang, Shwetha Hara Sridhar, Juan Soto, Swaroop Bose, Kent Madrid, Ethan Ellis, Elyze Merzier, Konstantinos Vlachos, Nataly Fishman, Manying Tin, Melissa Smith, Hui Xie, Manishkumar Patel, Kai Nie, Kimberly Argueta, Jocelyn Harris, Neha Karekar, Craig Batchelor, Jose Lacunza, Mahlet Yishak, Kevin Tuballes, Ieisha Scott, Arvind Kumar, Suraj Jaladanki, Charuta Agashe, Ryan Thompson, Evan Clark, Bojan Losic, Lauren Peters, The Mount Sinai COVID-19 Biobank Team, Panagiotis Roussos, Jun Zhu, Wenhui Wang, Andrew Kasarskis, Benjamin S. Glicksberg, Girish Nadkarni, Dusan Bogunovic, Cordelia Elaiho, Sandeep Gangadharan, George Ofori-Amanfo, Kasey Alesso-Carra, Kenan Onel, Karen M. Wilson, Carmen Argmann, Supinda Bunyavanich, Marta E. Alarcón-Riquelme, Thomas U. Marron, Adeeb Rahman, Seunghee Kim-Schulze, Sacha Gnjatic, Bruce D. Gelb, Miriam Merad, Robert Sebra, Eric E. Schadt, Alexander W. Charney

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Multisystem inflammatory syndrome in children (MIS-C) onsets in COVID-19 patients with manifestations similar to Kawasaki disease (KD). Here the author probe the peripheral blood transcriptome of MIS-C patients to find signatures related to natural k

Externí odkaz: https://doaj.org/article/7233a40d610f443eac2e6011b12c9368

A study of gene expression in the living human brain

Autor: Lora E. Liharska, You Jeong Park, Kimia Ziafat, Lillian Wilkins, Hannah Silk, Lisa M. Linares, Ryan C. Thompson, Eric Vornholt, Brendan Sullivan, Vanessa Cohen, Prashant Kota, Claudia Feng, Esther Cheng, Jessica S. Johnson, Marysia-Kolbe Rieder, Jia Huang, Joseph Scarpa, Jairo Polanco, Emily Moya, Alice Hashemi, Jaroslav Bendl, Gabriel E. Hoffman, Panos Roussos, Matthew A. Levin, Girish N. Nadkarni, Robert Sebra, John Crary, Pamela Sklar, Eric E. Schadt, Noam D. Beckmann, Brian H. Kopell, Alexander W. Charney

Publikováno v: medRxiv

A central goal of neuroscience is to advance knowledge of the molecular basis of human brain function. Most molecular studies of the human brain have been performed using tissue from postmortem brain donors rather than living people. The assumption u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e784c86b0eefe0e0d4e38c599b4111e0
https://doi.org/10.1101/2023.04.21.23288916

Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

Autor: Ryan C, Thompson, Nicole W, Simons, Lillian, Wilkins, Esther, Cheng, Diane Marie, Del Valle, Gabriel E, Hoffman, Carlo, Cervia, Brian, Fennessy, Konstantinos, Mouskas, Nancy J, Francoeur, Jessica S, Johnson, Lauren, Lepow, Jessica, Le Berichel, Christie, Chang, Aviva G, Beckmann, Ying-Chih, Wang, Kai, Nie, Nicholas, Zaki, Kevin, Tuballes, Vanessa, Barcessat, Mario A, Cedillo, Dan, Yuan, Laura, Huckins, Panos, Roussos, Thomas U, Marron, Benjamin S, Glicksberg, Girish, Nadkarni, James R, Heath, Edgar, Gonzalez-Kozlova, Onur, Boyman, Seunghee, Kim-Schulze, Robert, Sebra, Miriam, Merad, Sacha, Gnjatic, Eric E, Schadt, Alexander W, Charney, Renyuan, Zha

Publikováno v: Nature medicine.

Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A transcriptome-wide investigation was performed in 165 acutely infected hospi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b6ac85112a519224545c09eb7c72bdb
https://pubmed.ncbi.nlm.nih.gov/36482101

Antagonism between germ cell-less and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction

Autor: Paul Schedl, Gretchen Kappes, Girish Deshpande, Lillian Wilkins, Elias A Castro, Pearl V. Ryder, Dorothy A. Lerit, Megan M Colonnetta, Lauren R Lym

Publikováno v: eLife, Vol 10 (2021)

Transcriptional quiescence, an evolutionarily conserved trait, distinguishes the embryonic primordial germ cells (PGCs) from their somatic neighbors. InDrosophila melanogaster, PGCs from embryos maternally compromised forgerm cell-less(gcl) misexpres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57bc7ea1deab98ca2479f654f4f13661
https://elifesciences.org/articles/54346