Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lillian W. Chiang"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 10, p 1298 (2024)
Direct-acting anti-infective drugs target pathogen-coded gene products and are a highly successful therapeutic paradigm. However, they generally target a single pathogen or family of pathogens, and the targeted organisms can readily evolve resistance
Externí odkaz:
https://doaj.org/article/34ce56c71f8f4d92b746cf6076ce7ad5
An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity
Autor:
Kathryn L. Roche, Stacy Remiszewski, Matthew J. Todd, John L. Kulp III, Liudi Tang, Alison V. Welsh, Ashley P. Barry, Chandrav De, William W. Reiley, Angela Wahl, J. Victor Garcia, Micah A. Luftig, Thomas Shenk, James R. Tonra, Eain A. Murphy, Lillian W. Chiang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Most drugs used to treat viral disease target a virus-coded product. They inhibit a single virus or virus family, and the pathogen can readily evolve resistance. Host-targeted antivirals can overcome these limitations. The broad-spectrum activity ach
Externí odkaz:
https://doaj.org/article/aae26d7a4a0143a6b97410639780fe44
Autor:
Lillian W. Chiang, James D. Pomonis, Margaret E. Levin, Scott W. Miller, Daniel J. Lavery, Jeifei Tong, Rui-Ru Ji, Jason G. Jin
Publikováno v:
Pain. 137:182-201
Neuroinflammatory and neuroimmune mechanisms, as exemplified by infiltrating immune cells and activation of resident endothelial/glial cells, respectively, are known to be involved in the establishment and maintenance of chronic pain. An immune syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a2ce57d7deb3d7328ab481a1d59201
https://doi.org/10.1016/j.pain.2007.11.005
https://doi.org/10.1016/j.pain.2007.11.005
DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein
Autor:
Sandeep Robert Datta, Michael E. Greenberg, Jill M. Grenier, Anne Brunet, Albert J. Fornace, Lillian W. Chiang, Hien Tran, Peter S. DiStefano
Publikováno v:
Science. 296:530-534
The signaling pathway from phosphoinositide 3-kinase to the protein kinase Akt controls organismal life-span in invertebrates and cell survival and proliferation in mammals by inhibiting the activity of members of the FOXO family of transcription fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65ccdc07896f05b2c0afc1b7bc3b7c1
https://doi.org/10.1126/science.1068712
https://doi.org/10.1126/science.1068712
Autor:
Lillian W. Chiang
Publikováno v:
Current Genomics. 3:43-50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5327bcdcc07411b4866bb7f60c1c00c5
https://doi.org/10.2174/1389202023350624
https://doi.org/10.2174/1389202023350624
Autor:
Jill M. Grenier, Peter S. DiStefano, Lorayne Jenkins, Fenyu Jin, Andrew R. Wood, Laurence Ettwiller, Lillian W. Chiang, Dave Ficenec, John D. Martin
Publikováno v:
Proceedings of the National Academy of Sciences. 98:2814-2819
Programmed cell death (PCD) during neuronal development and disease has been shown to require de novo RNA synthesis. However, the time course and regulation of target genes is poorly understood. By using a brain-biased array of over 7,500 cDNAs, we p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4d39b3fa8c868247a580416c7c0b2d
https://doi.org/10.1073/pnas.051630598
https://doi.org/10.1073/pnas.051630598
Autor:
Lillian W. Chiang
Publikováno v:
Journal of Chromatography A. 806:209-218
Detection and quantitation of gene expression in single cells is especially important in the central nervous system where, at the cellular level, the synapse can be considered the single functional unit. For example, the consolidation of long-term me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5d9d2a0118a500b9830372590d7550
https://doi.org/10.1016/s0021-9673(98)00156-3
https://doi.org/10.1016/s0021-9673(98)00156-3
Autor:
Eva Keller, Stephanie E. Sillivan, Ying-Xian Pan, Yanhua Ren, Michelle M. Jacobs, Avi Ma'ayan, Mónika Csilla Horváth, Yasmin L. Hurd, Lillian W. Chiang, Francesca Felicia Caputi, Amin R. Mazloom, John D. Whittard
BACKGROUND: Abuse of heroin and prescription opiate medications has grown to disturbing levels. Opioids mediate their effects through mu opioid receptors (MOR), but minimal information exists regarding MOR-related striatal signaling relevant to the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27c2414c39a5391aae77e6ae1ca3f55
http://hdl.handle.net/11585/300514
http://hdl.handle.net/11585/300514
Autor:
Scott P. Hunicke-Smith, Ronald W. Davis, Lillian W. Chiang, John T. Mulligan, Peter J. Oefner, Fred S. Dietrich
Publikováno v:
Nucleic Acids Research. 24:3879-3886
Based on a high-performance liquid chromatographic pump, we have built a device that allows recirculation of DNA through a 63-microm orifice with ensuing fractionation to a minimum fragment size of approximately 300 base pairs. Residence time of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70599bc0102d4f02260306f808d878f6
https://doi.org/10.1093/nar/24.20.3879
https://doi.org/10.1093/nar/24.20.3879
Publikováno v:
Molecular Brain Research. 27:183-188
The presence of nitric oxide synthase (NOS) in CA1 pyramidal cells of the rat hippocampus was demonstrated by single-cell PCR. NOS-specific primers were used to amplify mRNA isolated from single hippocampal neurons. The sequence of the major amplific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4cbca0a5e640ef6bb2c364d4150157
https://doi.org/10.1016/0169-328x(94)90202-x
https://doi.org/10.1016/0169-328x(94)90202-x