Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Lillian Sun"'
Autor:
Yi An, Jun Jeon, Lillian Sun, Adeeb Derakhshan, Jianhong Chen, Sophie Carlson, Hui Cheng, Christopher Silvin, Xinping Yang, Carter Van Waes, Zhong Chen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Head and neck squamous cell carcinomas (HNSCC) induced by human papillomavirus (HPV) have increased recently in the US. However, the distinct alterations of molecules involved in the death pathways and drug effects targeting inhibitor of apo
Externí odkaz:
https://doaj.org/article/d665633856e14a8a985871ecd86fdb93
Autor:
Lillian Sun, Shuying Sun
Publikováno v:
BioData Mining, Vol 12, Iss 1, Pp 1-22 (2019)
Abstract Background DNA methylation is an epigenetic event that may regulate gene expression. Because of this regulation role, aberrant DNA methylation is often associated with many diseases. Within-sample DNA co-methylation is the similarity of meth
Externí odkaz:
https://doaj.org/article/554616c809914d37ae583468977d2f43
Autor:
Jay Friedman, Megan Morisada, Lillian Sun, Ellen C. Moore, Michelle Padget, James W. Hodge, Jeffrey Schlom, Sofia R. Gameiro, Clint T. Allen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-12 (2018)
Abstract Background Natural killer (NK) cells recognize and lyse target tumor cells in an MHC-unrestricted fashion and complement antigen- and MHC-restricted killing by T-lymphocytes. NK cells and T-lymphocytes mediate early killing of targets throug
Externí odkaz:
https://doaj.org/article/9452867cafaa4abaadb8103de56db9b3
Autor:
Lillian Sun, Pauline Funchain, Jung Min Song, Patricia Rayman, Charles Tannenbaum, Jennifer Ko, Michael Mcnamara, C. Marcela Diaz-Montero, Brian Gastman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-7 (2018)
Abstract Background Talimogene Laherparepvec (T-VEC) is an oncolytic virus approved as an intratumoral therapy for treating unresectable stage IIIB-IV metastatic melanoma. The mechanisms of action for T-VEC and checkpoint inhibitor are highly complem
Externí odkaz:
https://doaj.org/article/124dc33e31904fb0bb2a8553989ac7e9
Preliminary Analysis of Within-Sample Co-methylation Patterns in Normal and Cancerous Breast Samples
Publikováno v:
Cancer Informatics, Vol 18 (2019)
DNA methylation plays a significant role in regulating the expression of certain genes in both cancerous and normal breast tissues. It is therefore important to study within-sample co-methylation, ie, methylation patterns between consecutive sites in
Externí odkaz:
https://doaj.org/article/9273cf488c7841c095e6cb588d1ed9e8
Autor:
Lillian Sun, Ellen Moore, Rose Berman, Paul E. Clavijo, Anthony Saleh, Zhong Chen, Carter Van Waes, John Davies, Jay Friedman, Clint T. Allen
Publikováno v:
OncoImmunology, Vol 7, Iss 10 (2018)
Intrinsic resistance to cytotoxic T-lymphocyte (CTL) killing limits responses to immune activating anti-cancer therapies. Here, we established that activation of the G2/M cell cycle checkpoint results in tumor cell cycle pause and protection from gra
Externí odkaz:
https://doaj.org/article/f3759931fcaa401faa7315d5153a75be
Autor:
Ellen C. Moore, Lillian Sun, Paul E. Clavijo, Jay Friedman, Joe B. Harford, Anthony D. Saleh, Carter Van Waes, Esther H. Chang, Clint T. Allen
Publikováno v:
OncoImmunology, Vol 7, Iss 7 (2018)
Loss or mutation of TP53 has been linked to alterations in anti-tumor immunity as well as dysregulation of cell cycle and apoptosis. We explored immunologic effects and mechanisms following restoration of wild-type human TP53 cDNA in murine oral canc
Externí odkaz:
https://doaj.org/article/0597348176a347c2bbfba1afd61182b4
Autor:
Megan Morisada, Paul E. Clavijo, Ellen Moore, Lillian Sun, Michael Chamberlin, Carter Van Waes, James W. Hodge, James B. Mitchell, Jay Friedman, Clint T. Allen
Publikováno v:
OncoImmunology, Vol 7, Iss 3 (2018)
Preclinical evidence suggests that high-dose hypofractionated ionizing radiation (IR) can enhance anti-tumor immunity and result in significant tumor control when combined with immune checkpoint blockade (ICB). However, low-dose daily fractioned IR u
Externí odkaz:
https://doaj.org/article/615476c202fb489ba4348ddd94db19a2
Autor:
Lin Lawrence Guo, Jason Fries, Ethan Steinberg, Scott Lanyon Fleming, Keith Morse, Catherine Aftandilian, Jose Posada, Nigam Shah, Lillian Sung
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Foundation models are transforming artificial intelligence (AI) in healthcare by providing modular components adaptable for various downstream tasks, making AI development more scalable and cost-effective. Foundation models for structured el
Externí odkaz:
https://doaj.org/article/bc024ab4b59f443d94c32dab6a226ca1
Autor:
Paul Zolkind, Ravindra Uppaluri, Megan Morisada, Jay Friedman, Paul E. Clavijo, Wojciech K. Mydlarz, Clint T. Allen, Ellen C. Moore, James W. Hodge, Sarah Greene, Hans Schreiber, Lillian Sun, Nicole C. Schmitt, Carter Van Waes, Yvette Robbins
Publikováno v:
Clin Cancer Res
Purpose: Surgical resection of primary tumor with regional lymphadenectomy remains the treatment of choice for patients with advanced human papillomavirus–negative head and neck squamous cell carcinoma. However, even when pathologic disease-free ma