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Publikováno v:
Metabolism. 41:1125-1133
To assess the effect of hyperglycemia on the function of islets obtained from obese rats, the behavior of isolated islets from LA/N-corpulent (nondiabetic obese) and SHR/N-corpulent (diabetic obese) male rats was examined and compared. Islets from bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa686914745131b1ea1ef8b5fbdbe7f8
https://doi.org/10.1016/0026-0495(92)90298-o
https://doi.org/10.1016/0026-0495(92)90298-o
Autor:
Darley Solomon, Lillian Recant, Andrea M. Powell, Kim I. Timmers, Samuel D. Wilkins, Sam J. Bhathena, Nancy R. Voyles
Publikováno v:
Diabetes. 39:1436-1444
To examine the biochemical mechanisms by which hyperglycemia produces insulin secretory abnormalities, we studied isolated islets from control rats and rats infused for 48 h with a 50% glucose solution. To preserve the effects of in vivo hyperglycemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413a2122b315d87972d78a0be4f02237
https://doi.org/10.2337/diab.39.11.1436
https://doi.org/10.2337/diab.39.11.1436
Autor:
Nancy R. Voyles, Andrea M. Powell, Kim I. Timmers, Åke Rökaeus, Douglas L. Coleman, Lillian Recant
Publikováno v:
Metabolism. 39:378-383
The nature of the primary genetic defects in ob/ob and db/db mice are unknown. Both the obese (ob) and diabetes (db) mutations produce similar, multicomponent obese-hyperinsulinemic syndromes when maintained in the same strain of mouse. In an attempt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691c90783f5d7e686122e073278b154c
https://doi.org/10.1016/0026-0495(90)90252-8
https://doi.org/10.1016/0026-0495(90)90252-8
Publikováno v:
Peptides. 1:309-313
Naltrexone, an opiate antagonist, was administered to young obese (ob/ob) and lean mice for five weeks. Animals had continuous access to food and received 10 mg/kg SC twice daily with equivalent volumes of saline given to controls. The effects on bod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea27ba73ce1d747c0868aa87e50bf93
https://doi.org/10.1016/0196-9781(80)90008-x
https://doi.org/10.1016/0196-9781(80)90008-x
Publikováno v:
Diabetes. 34:717-722
Rat insulinoma cells, which grow in culture and secrete insulin, were used to study the mechanism of stimulation of insulin release by glucagon. The parent cell line (RIN-m) and a clone that secretes high levels of insulin (5F) had been shown to poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8bb7ef4eff3c62b7eff6545b8eb5a3
https://doi.org/10.2337/diab.34.8.717
https://doi.org/10.2337/diab.34.8.717
Publikováno v:
Journal of Clinical Investigation. 61:1488-1497
The effects of endogenous and exogenous hyperglucagonemia on the specific binding of glucagon to hepatocyte receptors was studied, as was the response of cAMP to glucagon. In streptozotocin diabetic rats, blood glucose and plasma glucagon increased a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c089e3ed5c05f8b72d1535264288ff34
https://doi.org/10.1172/jci109069
https://doi.org/10.1172/jci109069
Publikováno v:
Life Sciences. 45:901-906
A simple, rapid and reliable procedure is described to simultaneously concentrate and purify β-endorphin, leu- and met-enkephalins from small volumes of human and rat plasma before radioimmunoassay is performed. It uses C 18 Sep-Pak reverse phase ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cbb5daf50b2097576b33919c2e7b84
https://doi.org/10.1016/0024-3205(89)90204-x
https://doi.org/10.1016/0024-3205(89)90204-x
Publikováno v:
Diabetes. 23:505-511
Our laboratory has had a good experience using the gel filtration assay for proinsulin. Since the proteolytic enzymatic assay for proinsulin has the reported advantage of being simpler and requiring less plasma per assay, a comparison was made of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e028482e271bc78006127ec41e84fdd
https://doi.org/10.2337/diab.23.6.505
https://doi.org/10.2337/diab.23.6.505
Autor:
Adi F. Gazdar, Lillian Recant, Geraldine P. Schechter, Frances E. Soehnlen, Edward K. Russell, Sam J. Bhathena, Andrey Gritsman
Publikováno v:
Endocrinology. 111:684-692
Activation of T- and B-lymphocytes by a variety of immunological stimuli has been reported to induce specific insulin receptors. The purpose of the present work was to determine whether glucagon receptors are also induced in activated cells. Studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9168405ce22bed7de77948ae59243267
https://doi.org/10.1210/endo-111-2-684
https://doi.org/10.1210/endo-111-2-684