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pro vyhledávání: '"Lillian R. Klug"'
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Prior to the early 2000s, patients with advanced gastrointestinal stromal tumors (GIST) had very poor prognoses owing to a lack of effective therapies. The development of tyrosine kinase inhibitors at the turn of the century significantly improved th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38a02ac08542ee00f2e8bf75c759d12
https://doi.org/10.1007/s40265-022-01820-1
https://doi.org/10.1007/s40265-022-01820-1
Autor:
Michael C. Heinrich, Ajia Town, Carol Beadling, Diana J. Griffith, Janice Patterson, Lillian R. Klug, Alison C. Macleod
Figure S1: HMC1.2 cell line has constitutively actived NFAT2, NFAT2 and NFAT4 species; Figure S2: RT-PCR of transcripts modulated by 24 hour treatment with CSA; Figure S3: CNPIs do not modulate KIT signaling and KIT inhibitors do not affect NFAT loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e518f583acccdf8a901bb064a3d220b
https://doi.org/10.1158/1535-7163.22500676
https://doi.org/10.1158/1535-7163.22500676
Autor:
Sebastian Bauer, Michael C. Heinrich, Daniel Rauh, Oleg Schmidt-Kittler, Stephen Miller, Paul Czodrowski, Sascha Jung, Jonathan A. Fletcher, Juergen Treckmann, Hans-Ulrich Schildhaus, Wolfgang Hartmann, Eva Wardelmann, Christiane Ehrt, Ajia Town, Johanna Falkenhorst, Jonas Lategahn, Thomas Mühlenberg, Lillian R. Klug, Susanne Grunewald
Gastrointestinal stromal tumors (GIST) harboring activating mutations of PDGFRA respond to imatinib, with the notable exception of the most common mutation, D842V. Avapritinib is a novel, potent KIT/PDGFRA inhibitor with substantial clinical activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b3f20d7693dc0c2d93617aad750144e
https://doi.org/10.1158/2159-8290.c.6548281.v1
https://doi.org/10.1158/2159-8290.c.6548281.v1
Autor:
Sebastian Bauer, Michael C. Heinrich, Daniel Rauh, Oleg Schmidt-Kittler, Stephen Miller, Paul Czodrowski, Sascha Jung, Jonathan A. Fletcher, Juergen Treckmann, Hans-Ulrich Schildhaus, Wolfgang Hartmann, Eva Wardelmann, Christiane Ehrt, Ajia Town, Johanna Falkenhorst, Jonas Lategahn, Thomas Mühlenberg, Lillian R. Klug, Susanne Grunewald
Contains: Supplemental Figures 1-7; Supplemental Tables 1 -3; Supplemental Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375ce012bfe7faa0ce9de0e72de07295
https://doi.org/10.1158/2159-8290.22536943
https://doi.org/10.1158/2159-8290.22536943
Autor:
Michael C. Heinrich, Ajia Town, Carol Beadling, Diana J. Griffith, Janice Patterson, Lillian R. Klug, Alison C. Macleod
Resistant KIT mutations have hindered the development of KIT kinase inhibitors for treatment of patients with systemic mastocytosis. The goal of this research was to characterize the synergistic effects of a novel combination therapy involving inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16ae29e89fef41b4d92af10f6b06768c
https://doi.org/10.1158/1535-7163.c.6536539.v1
https://doi.org/10.1158/1535-7163.c.6536539.v1
Autor:
Michael C. Heinrich, Ajia Town, Carol Beadling, Diana J. Griffith, Janice Patterson, Lillian R. Klug, Alison C. Macleod
Figure and table legends for supplemental figures 1-4 and supplemental tables 1-3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a17edf6b5a847610c5bbe2106c2323e
https://doi.org/10.1158/1535-7163.22500679.v1
https://doi.org/10.1158/1535-7163.22500679.v1
Autor:
Michael C. Heinrich, Ujwal Shinde, Christopher Corless, Jason K. Sicklick, Oliver Harismendy, Carol Beadling, Kelly McCann, Lillian R. Klug, Ajia Town, Isaac Forquer, Jason Kent, Amber E. Bannon
Purpose: Patients who inherit a pathogenic loss-of-function genetic variant involving one of the four succinate dehydrogenase (SDH) subunit genes have up to an 86% chance of developing one or more cancers by the age of 50. If tumors are identified an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3a5a605d8ced1c183bff44000e3485
https://doi.org/10.1158/1078-0432.c.6526874
https://doi.org/10.1158/1078-0432.c.6526874
Autor:
Michael C. Heinrich, Ujwal Shinde, Christopher Corless, Jason K. Sicklick, Oliver Harismendy, Carol Beadling, Kelly McCann, Lillian R. Klug, Ajia Town, Isaac Forquer, Jason Kent, Amber E. Bannon
TIFF file for supplemental figure 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1dc565c5e4ed85dd4751f41ed47cdf
https://doi.org/10.1158/1078-0432.22468244.v1
https://doi.org/10.1158/1078-0432.22468244.v1
Autor:
Michael C. Heinrich, Ujwal Shinde, Christopher Corless, Jason K. Sicklick, Oliver Harismendy, Carol Beadling, Kelly McCann, Lillian R. Klug, Ajia Town, Isaac Forquer, Jason Kent, Amber E. Bannon
TIFF file for supplemental figure 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e8765299eaffb881c2372f926ecd15
https://doi.org/10.1158/1078-0432.22468247
https://doi.org/10.1158/1078-0432.22468247
Autor:
Michael C. Heinrich, Ujwal Shinde, Christopher Corless, Jason K. Sicklick, Oliver Harismendy, Carol Beadling, Kelly McCann, Lillian R. Klug, Ajia Town, Isaac Forquer, Jason Kent, Amber E. Bannon
Video for Biochemical, molecular, and clinical characterization of SDHA VUS from Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3840ab0a53c1dbb5ab2323a20d206831
https://doi.org/10.1158/1078-0432.22468238.v1
https://doi.org/10.1158/1078-0432.22468238.v1