Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lillian R. Kenner"'
Autor:
Renee Otten, Lin Liu, Lillian R. Kenner, Michael W. Clarkson, David Mavor, Dan S. Tawfik, Dorothee Kern, James S. Fraser
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
A key challenge in the field of protein design and evolution is to understand the mechanisms by which directed evolution is improving enzymes. Here the authors combine different biophysical methods and give mechanistic insights into how directed evol
Externí odkaz:
https://doaj.org/article/92e5d2150eec485a8a3eef20778b77f0
Autor:
David Mavor, Kyle A. Barlow, Daniel Asarnow, Yuliya Birman, Derek Britain, Weilin Chen, Evan M. Green, Lillian R. Kenner, Bruk Mensa, Leanna S. Morinishi, Charlotte A. Nelson, Erin M. Poss, Pooja Suresh, Ruilin Tian, Taylor Arhar, Beatrice E. Ary, David P. Bauer, Ian D. Bergman, Rachel M. Brunetti, Cynthia M. Chio, Shizhong A. Dai, Miles S. Dickinson, Susanna K. Elledge, Cole V. M. Helsell, Nathan L. Hendel, Emily Kang, Nadja Kern, Matvei S. Khoroshkin, Lisa L. Kirkemo, Greyson R. Lewis, Kevin Lou, Wesley M. Marin, Alison M. Maxwell, Peter F. McTigue, Douglas Myers-Turnbull, Tamas L. Nagy, Andrew M. Natale, Keely Oltion, Sergei Pourmal, Gabriel K. Reder, Nicholas J. Rettko, Peter J. Rohweder, Daniel M. C Schwarz, Sophia K. Tan, Paul V. Thomas, Ryan W. Tibble, Jason P. Town, Mary K. Tsai, Fatima S. Ugur, Douglas R. Wassarman, Alexander M. Wolff, Taia S. Wu, Derek Bogdanoff, Jennifer Li, Kurt S. Thorn, Shane O'Conchúir, Danielle L. Swaney, Eric D. Chow, Hiten D. Madhani, Sy Redding, Daniel N. Bolon, Tanja Kortemme, Joseph L. DeRisi, Martin Kampmann, James S. Fraser
Publikováno v:
Biology Open, Vol 7, Iss 7 (2018)
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the di
Externí odkaz:
https://doaj.org/article/120375a9425d4b15800ba82e59af4543
Autor:
Si-Han Chen, Sumit Prakash, Elizabeth Helgason, Caroline L. Gilchrist, Lillian R. Kenner, Rajini Srinivasan, Tim Sterne-Weiler, Marc Hafner, Robert Piskol, Erin C. Dueber, Habib Hamidi, Nicholas Endres, Xin Ye, Wayne J. Fairbrother, Ingrid E. Wertz
Modulation of proteolysis is an emerging therapeutic mainstay. The clinical success of thalidomide and analogs has inspired development of rationally-designed therapeutics that repurpose endogenous degradation machinery to target pathogenic proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::263fcd1748657baa60bcc9f96316c6b2
https://doi.org/10.1101/2023.02.06.527237
https://doi.org/10.1101/2023.02.06.527237
Autor:
David Mavor, Kyle Barlow, Samuel Thompson, Benjamin A Barad, Alain R Bonny, Clinton L Cario, Garrett Gaskins, Zairan Liu, Laura Deming, Seth D Axen, Elena Caceres, Weilin Chen, Adolfo Cuesta, Rachel E Gate, Evan M Green, Kaitlin R Hulce, Weiyue Ji, Lillian R Kenner, Bruk Mensa, Leanna S Morinishi, Steven M Moss, Marco Mravic, Ryan K Muir, Stefan Niekamp, Chimno I Nnadi, Eugene Palovcak, Erin M Poss, Tyler D Ross, Eugenia C Salcedo, Stephanie K See, Meena Subramaniam, Allison W Wong, Jennifer Li, Kurt S Thorn, Shane Ó Conchúir, Benjamin P Roscoe, Eric D Chow, Joseph L DeRisi, Tanja Kortemme, Daniel N Bolon, James S Fraser
Publikováno v:
eLife, Vol 5 (2016)
Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance
Externí odkaz:
https://doaj.org/article/f3e8373dbc7b4012a1c82425c9fb49fb
Autor:
Daniel A Keedy, Lillian R Kenner, Matthew Warkentin, Rahel A Woldeyes, Jesse B Hopkins, Michael C Thompson, Aaron S Brewster, Andrew H Van Benschoten, Elizabeth L Baxter, Monarin Uervirojnangkoorn, Scott E McPhillips, Jinhu Song, Roberto Alonso-Mori, James M Holton, William I Weis, Axel T Brunger, S Michael Soltis, Henrik Lemke, Ana Gonzalez, Nicholas K Sauter, Aina E Cohen, Henry van den Bedem, Robert E Thorne, James S Fraser
Publikováno v:
eLife, Vol 4 (2015)
Determining the interconverting conformations of dynamic proteins in atomic detail is a major challenge for structural biology. Conformational heterogeneity in the active site of the dynamic enzyme cyclophilin A (CypA) has been previously linked to i
Externí odkaz:
https://doaj.org/article/20ede3c217614534b0cc830dee6b77a3
Autor:
Michael J. Feyder, Adam Frost, Guendalina Rossi, Patrick Brennwald, Mary Munson, Lillian R. Kenner, Dante M. Lepore, Jacqueline M. Forson, Leonora Martínez-Núñez, Alexander B Czuchra
Publikováno v:
Biophysical Journal. 118:340a-341a
Autor:
Dante M. Lepore, Mary Munson, Adam Frost, Patrick Brennwald, Alexander B Czuchra, Guendalina Rossi, Melissa Plooster, Lillian R. Kenner
Publikováno v:
The Journal of Cell Biology
The Journal of cell biology, vol 219, iss 2
The Journal of cell biology, vol 219, iss 2
Rossi et al. describe a novel assay for exocyst in-vesicle tethering. In this assay, gain-of-function mutants in the Exo70 subunit of the exocyst, which bypass Rho/Cdc42 activation in vivo, stimulate vesicle tethering. Single-particle EM studies reve
Autor:
Lillian R. Kenner, Aditya A. Anand, Henry C. Nguyen, Alexander G. Myasnikov, Carolin J. Klose, Lea A. McGeever, Jordan C. Tsai, Lakshmi E. Miller-Vedam, Peter Walter, Adam Frost
Publikováno v:
Science
Science, 2019, 364 (6439), pp.491-495. ⟨10.1126/science.aaw2922⟩
Science (New York, N.Y.), vol 364, iss 6439
Science, 2019, 364 (6439), pp.491-495. ⟨10.1126/science.aaw2922⟩
Science (New York, N.Y.), vol 364, iss 6439
Integrated stress response on the brain During translation, regulation of protein synthesis by phosphorylation of eukaryotic translation initiation factor 2 (eIF2) is a common consequence of diverse stress stimuli, which leads to reprogramming of gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7071027d8e2bb146106bc88eb039786
https://hal.archives-ouvertes.fr/hal-03698402
https://hal.archives-ouvertes.fr/hal-03698402
Autor:
Lillian R. Kenner, Henry C. Nguyen, Lakshmi E. Miller-Vedam, Lea A. McGeever, Aditya A. Anand, Carolin J. Klose, Jordan C. Tsai, Alexander G. Myasnikov, Adam Frost, Peter Walter
The integrated stress response (ISR) tunes the rate of protein synthesis. Control is exerted by phosphorylation of the general translation initiation factor eIF2. eIF2 is a GTPase, that becomes activated by eIF2B, a large two-fold symmetric and heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbed34416e124c55bd1e55ad9a8f6375
Autor:
Mary Munson, Lillian R. Kenner, Leonora Martínez-Núñez, Michael J. Feyder, Dante M. Lepore, Guendalina Rossi, Alexander B Czuchra, Patrick Brennwald, Adam Frost
Publikováno v:
The FASEB Journal. 34:1-1