Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lillian M, Toomey"'
Autor:
Lillian M. Toomey, Melissa Papini, Brittney Lins, Alexander J. Wright, Andrew Warnock, Terence McGonigle, Sarah C. Hellewell, Carole A. Bartlett, Chidozie Anyaegbu, Melinda Fitzgerald
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Cuprizone is a copper-chelating agent that induces pathology similar to that within some multiple sclerosis (MS) lesions. The reliability and reproducibility of cuprizone for inducing demyelinating disease pathology depends on the animals in
Externí odkaz:
https://doaj.org/article/580b3adbc43c41d781115c06f9481e95
Autor:
C. Bartlett, Melinda Fitzgerald, Sarah C Hellewell, Alexander J Wright, Brittney R. Lins, Terence McGonigle, Chidozie C. Anyaegbu, Melissa Papini, Lillian M. Toomey, Andrew Warnock
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Cuprizone is a copper-chelating agent that induces pathology similar to that within some multiple sclerosis (MS) lesions. The reliability and reproducibility of cuprizone for inducing demyelinating disease pathology depends on the animals ingesting c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d706e44bd5329c4bc3f0614191de9a
https://doaj.org/article/580b3adbc43c41d781115c06f9481e95
https://doaj.org/article/580b3adbc43c41d781115c06f9481e95
Autor:
Chidozie C. Anyaegbu, Yerim Won, Melinda Fitzgerald, Lillian M. Toomey, Alexander J Wright, Andrew Warnock, Katherine Fisher
Publikováno v:
Journal of Neurotrauma. 37:739-769
Traumatic brain injury (TBI) and spinal cord injury (SCI) present a significant contribution to the global disease burden. White matter tracts are susceptible to both the physical forces of trauma and cascades of pathological secondary degeneration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac90f3545d2685102c62de372967075c
https://doi.org/10.1089/neu.2019.6890
https://doi.org/10.1089/neu.2019.6890
Autor:
Lillian M. Toomey, Melissa G. Papini, Thomas O. Clarke, Alexander J. Wright, Eleanor Denham, Andrew Warnock, Terry McGonigle, Carole A. Bartlett, Melinda Fitzgerald, Chidozie C. Anyaegbu
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3463
Volume 24
Issue 4
Pages: 3463
Optic nerve injury causes secondary degeneration, a sequela that spreads damage from the primary injury to adjacent tissue, through mechanisms such as oxidative stress, apoptosis, and blood-brain barrier (BBB) dysfunction. Oligodendrocyte precursor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e9b34e994cf45186ecd307c095623a
https://doi.org/10.3390/ijms24043463
https://doi.org/10.3390/ijms24043463
Autor:
Nikolas Gavriel, Chloe G. G. Gray, Marck Norret, Carole A. Bartlett, Sarah A. Dunlop, Priya S. R. Naidu, Melinda Fitzgerald, Nicolas L. Taylor, Charmaine Hee, Jessica A. Kretzmann, K. Swaminathan Iyer, Diwei Ho, Nicole M. Smith, Lillian M. Toomey, Eleanor Denham, Terence McGonigle, Diana Patalwala
Publikováno v:
ACS Applied Materials & Interfaces. 11:22085-22095
The adsorption of serum proteins on the surface of nanoparticles (NPs) delivered into a biological environment has been known to alter NP surface properties and consequently their targeting efficiency. In this paper, we use random copolymer (p(HEMA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5337caedbe7319420717ff137652004e
https://doi.org/10.1021/acsami.9b01356
https://doi.org/10.1021/acsami.9b01356
Autor:
Maimuna Majimbi, Melinda Fitzgerald, Carole A. Bartlett, Gopana Gopalasingam, Jennifer Rodger, Lillian M. Toomey
Publikováno v:
Experimental Brain Research. 237:161-171
Following neurotrauma, secondary degeneration of neurons and glia adjacent to the injury leads to further functional loss. A combination of ion channel inhibitors (lomerizine + oxATP + YM872) has been shown to be effective at limiting structural and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6089cd57ef59d13c6b916139371276
https://doi.org/10.1007/s00221-018-5414-0
https://doi.org/10.1007/s00221-018-5414-0
Autor:
Melinda Fitzgerald, Jennifer Rodger, Maimuna Majimbi, Nikolas Gavriel, Carole A. Bartlett, Gopana Gopalasingam, Lillian M. Toomey, Terence McGonigle
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Injury to the central nervous system is exacerbated by secondary degeneration. Previous research has shown that a combination of orally and locally administered ion channel inhibitors following partial optic nerve injury protects the myelin sheath an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01a24de1759fa1b5a5700ecfcf453b5
http://europepmc.org/articles/PMC6814709
http://europepmc.org/articles/PMC6814709
Autor:
Alexander Gough, Melinda Fitzgerald, Andrew Warnock, Gopana Gopalasingam, Carole A. Bartlett, Terence McGonigle, Abbey Ford, Maimuna Majimbi, Lillian M. Toomey
Publikováno v:
Multiple sclerosis and related disorders. 34
Background Multiple sclerosis (MS) has been shown to feature oxidative damage, which can be modelled using the cuprizone model of demyelinating disease. Oxidative damage can occur as a result of excessive influx of calcium ions (Ca2+) and oligodendro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580c346dcd50b654c0696d098e249807
https://pubmed.ncbi.nlm.nih.gov/31202958
https://pubmed.ncbi.nlm.nih.gov/31202958
Autor:
K. Swaminathan Iyer, Paul Guagliardo, Carole A. Bartlett, Nicole M. Smith, Melinda Fitzgerald, Marcus K. Giacci, Lillian M. Toomey, Matt R. Kilburn, Haibo Jiang
Publikováno v:
Journal of Experimental Neuroscience, Vol 12 (2018)
Journal of Experimental Neuroscience
Journal of Experimental Neuroscience
Loss of function following injury to the CNS is worsened by secondary degeneration of neurons and glia surrounding the injury and is initiated by oxidative damage. However, it is not yet known which cellular populations and structures are most vulner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4119bdb4d15c28b3f351c0750a82d176
https://pubmed.ncbi.nlm.nih.gov/29915135
https://pubmed.ncbi.nlm.nih.gov/29915135
Autor:
Hannah R, Milbourn, Lillian M, Toomey, Nikolas, Gavriel, Chloe G G, Gray, Alexander H, Gough, Brooke, Fehily, Marcus K, Giacci, Melinda, Fitzgerald
Publikováno v:
Discovery medicine. 23(129)
Following injury to the central nervous system, secondary degeneration is mediated by Ca2+ imbalances and overproduction of reactive oxygen species from mitochondria, and is associated with myelin deficits and loss of function. Preventing intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04933786df4e88e3fd575602027acb75
https://pubmed.ncbi.nlm.nih.gov/28877447
https://pubmed.ncbi.nlm.nih.gov/28877447