Selected Thoughts on Hydrophobicity in Drug Design

Autor: Lillian L. Lou, John C. Martin

Publikováno v: Molecules, Vol 26, Iss 4, p 875 (2021)

The fundamental aim of drug design in research and development is to invent molecules with selective affinity towards desired disease-associated targets. At the atomic loci of binding surfaces, systematic structural variations can define affinities b

Externí odkaz: https://doaj.org/article/345f7ce64d5849348cee372abdc86f75

The stereospecificity of protein kinases

Autor: Steven Clarke, Philip N. McFadden, Lillian L. Lou, Kurt Drickamer

Publikováno v: Archives of Biochemistry and Biophysics. 259:227-233

To test whether cellular protein kinases exist that phosphorylate d -amino acid residues, a method was developed for separating O-phospho- d -serine from O-phospho- l -serine and O-phospho- l -tyrosine from O-phospho- d -tyrosine. This was accomplish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e6dc3676ed0c461f1d4c9dccff7aa3
https://doi.org/10.1016/0003-9861(87)90490-5

Multifunctional Ca2+/calmodulin-dependent protein kinase: domain structure and regulation

Autor: Lillian L. Lou, Howard Schulman

Publikováno v: Trends in Biochemical Sciences. 14:62-66

Cells respond to many hormones, neurotransmitters and growth factors by increasing intracellular Ca2+. This second messenger, in turn, affects cellular function via activation of a novel multifunctional Ca2+/calmodulin-dependent protein kinase. The k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4896b58da2442e42d092f7dc4b7ff025
https://doi.org/10.1016/0968-0004(89)90045-5

Dialysis nurses' knowledge, attitude, practice and self-efficacy regarding vascular access: A cross-sectional study in Singapore.

Autor: Meng L; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Cardiac, Thoracic and Vascular Surgery, National University Health System, Singapore, Singapore., Guo W; Department of Nephrology, Tan Tock Seng Hospital, Singapore, Singapore., Lou L; TAL Dialysis @ Clementi, Singapore, Singapore., Teo BW; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Nephrology, Department of Medicine, University Medicine Cluster, National University Health System, Singapore, Singapore., Ho P; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Cardiac, Thoracic and Vascular Surgery, National University Health System, Singapore, Singapore.

Publikováno v: The journal of vascular access [J Vasc Access] 2024 Sep; Vol. 25 (5), pp. 1432-1442. Date of Electronic Publication: 2023 Mar 27.

Combination of Tenofovir Disoproxil Fumarate and Peginterferon α-2a Increases Loss of Hepatitis B Surface Antigen in Patients With Chronic Hepatitis B.

Autor: Marcellin P; Service d'Hépatologie, Hôpital Beaujon, University Paris-Diderot, Inserm Centre de Recherche sur l'Inflammation, Clichy, France., Ahn SH; Division of Gastroenterology, Yonsei University College of Medicine, Seoul, South Korea., Ma X; Drexel University College of Medicine, Philadelphia, Pennsylvania., Caruntu FA; National Institute for Infectious Diseases, 'Matei Bals', Bucharest, Romania., Tak WY; Kyungpook National University Hospital, Daegu, South Korea., Elkashab M; Toronto Liver Center, Toronto, Canada., Chuang WL; Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan., Lim SG; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tabak F; University of Istanbul, Cerrahpasa Medical Faculty, Istanbul, Turkey., Mehta R; Liver Clinic, Surat, India., Petersen J; IFI Institute for Interdisciplinary Medicine at the Asklepios Klinik St. George, University of Hamburg, Hamburg, Germany., Foster GR; Queen Mary University of London, London, United Kingdom., Lou L; Nexus Development, Palo Alto, California., Martins EB; Gilead Sciences Inc, Foster City, California., Dinh P; Gilead Sciences Inc, Foster City, California., Lin L; Gilead Sciences Inc, Foster City, California., Corsa A; Gilead Sciences Inc, Foster City, California., Charuworn P; Gilead Sciences Inc, Foster City, California., Subramanian GM; Gilead Sciences Inc, Foster City, California., Reiser H; Gilead Sciences Inc, Foster City, California., Reesink HW; Academic Medical Center, Amsterdam, The Netherlands., Fung S; University of Toronto, Department of Medicine, Toronto General Hospital, Toronto, Canada., Strasser SI; AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia., Trinh H; San Jose Gastroenterology, San Jose, California., Buti M; Hepatology Unit, Hospital Universitari Vall d'Hebron and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas del Instituto Carlos III, Barcelona, Spain., Gaeta GB; Viral Hepatitis Unit, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy., Hui AJ; The Chinese University of Hong Kong, Alice Ho Miu Ling Nethersole Hospital, Hong Kong., Papatheodoridis G; Athens University Medical School, 'Laiko' General Hospital of Athens, Athens, Greece., Flisiak R; Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland., Chan HL; Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong. Electronic address: hlychan@cuhk.edu.hk.

Publikováno v: Gastroenterology [Gastroenterology] 2016 Jan; Vol. 150 (1), pp. 134-144.e10. Date of Electronic Publication: 2015 Oct 08.