Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Lillian F. Schmaltz"'
Publikováno v:
Biochemical Journal. 480:573-585
Various alkylating agents are known to preferentially modify guanine in DNA, resulting in the formation of N7-alkylguanine (N7-alkylG) and the imidazole ring opened alkyl-formamidopyrimidine (alkyl-FapyG) lesions. Evaluating the mutagenic effects of
Publikováno v:
Biochemical Journal. 479:2297-2309
If left unrepaired, the major oxidative DNA lesion 7,8-dihydro-8-oxoguanine (oxoG) promotes G-to-T transversions by favorably adopting a syn conformation and base pairing with dATP during replication. The human oxoG DNA glycosylase hOGG1 senses and r