Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lilli Ann Wolf-Gouveia"'
Autor:
Marcie Vaughn, Jennifer L. Liras, Lori L. Lopresti-Morrow, Sue A. Yocum, Francis J. Sweeney, Thomas J. Carty, Marcia A. Bliven, V. Natarajan, John T. Barberia, Lisa M. Reeves, Sheri L. Snow, Mark C. Noe, Peter G. Mitchell, Lilli Ann Wolf-Gouveia, Ivan G. Otterness
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3385-3388
A series of 3-hydroxy-3-methylpipecolic hydroxamate inhibitors of MMP-13 and aggrecanase was designed based on the observation of increased aggrecanase activity with substitution at the 3-position of the piperidine ring. Potency versus aggrecanase wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e77a74198be1c6cd9bf69d4a5fb5db
https://doi.org/10.1016/j.bmcl.2005.05.037
https://doi.org/10.1016/j.bmcl.2005.05.037
Autor:
Lori L. Lopresti-Morrow, Sheri L. Snow, Mark C. Noe, Lisa M. Reeves, Peter G. Mitchell, Jennifer L. Liras, Lilli Ann Wolf-Gouveia, Sue A. Yocum, Marcie Vaughn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4727-4730
N-Hydroxy-3-hydroxy-4-arylsulfonyltetrahydropyranyl-3-carboxamides were designed as novel inhibitors of MMP-13 and aggrecanase based on known endocyclic hydroxamate inhibitors of matrix metalloproteinases. These compounds offer favorable physicochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9181772accd8c105c456e41ddd377943
https://doi.org/10.1016/j.bmcl.2004.06.081
https://doi.org/10.1016/j.bmcl.2004.06.081
Autor:
Lilli Ann Wolf-Gouveia, Paul D. Lira, Eric B. McElroy, Lisa Marie Thomasco, Matthew Frank Brown, Christopher S. Jones, Jonathan L. Doty, Lawrence A. Reiter, Sandra P. McCurdy, Anthony Marfat, Sharon L. Ripp, Mark J. Mitton-Fry, William H. Brissette, Andrei Shavnya, Linde Robert Gerald, Thomas M. Harris, Kristen A. Trevena, Qifang Li, Laura Cook Blumberg, Amy S. Antipas, James P. Driscoll, Michael John Munchhof, Jeffrey M. Casavant
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1428-1430
Recently, we disclosed a series of potent pyrimidine benzamide-based thrombopoietin receptor agonists. Unfortunately, the structural features required for the desired activity conferred physicochemical properties that were not favorable for the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c13f353a20302d8bc86c0f3e090d44
https://doi.org/10.1016/j.bmcl.2009.01.032
https://doi.org/10.1016/j.bmcl.2009.01.032
Autor:
Diana Sperger, Laura Cook Blumberg, Emilio J. Mangual, Kristen A. Trevena, Christopher S. Jones, Jonathan L. Doty, Fangning Zhang, William H. Brissette, Marc I. Smeets, Qifang Li, Paul D. Lira, Amy S. Antipas, Lilli Ann Wolf-Gouveia, Sandra P. McCurdy, Lisa Marie Thomasco, Andrei Shavnya, Sharon L. Ripp, Richard M. Shepard, Liling Zhang, Chakrapani Subramanyam, Linde Robert Gerald, Michael John Munchhof, Lawrence A. Reiter, James P. Driscoll
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(19)
A series of pyrimidine benzamide-based thrombopoietin receptor agonists is described. The lead molecule contains a 2-amino-5-unsubstituted thiazole, a group that has been associated with idiosyncratic toxicity. The potential for metabolic oxidation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28920ad58a16caa053bbc11c89c4ece
https://pubmed.ncbi.nlm.nih.gov/17707640
https://pubmed.ncbi.nlm.nih.gov/17707640
Autor:
Christopher S. Jones, Jennifer L. Liras, Sue A. Yocum, Joel R. Hardink, Shang-Poa P. Chang, Julian Blagg, Lilli Ann Wolf-Gouveia, Ralph P. Robinson, Mark C. Noe, Peter G. Mitchell, Nancy C. Elliott, Amber I. Haugeto, Jayvardhan Pandit, R. J. Griffiths, Ellen R. Laird, Lawrence A. Reiter, James D. Eskra, Marcie L. Vaughn-Bowser, Chakrapani Subramanyam, James T. Downs, Lori L. Lopresti-Morrow, Dennis E. Danley
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(7)
Through the use of computational modeling, a series of pyrimidinetrione-based inhibitors of MMP-13 was designed based on a lead inhibitor identified through file screening. Incorporation of a biaryl ether moiety at the C-5 position of the pyrimidinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1b93251818383c7c6286b45657c782
https://pubmed.ncbi.nlm.nih.gov/15780611
https://pubmed.ncbi.nlm.nih.gov/15780611