Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Liljana Gentschew"'
Autor:
Friederike Flachsbart, Janina Dose, Liljana Gentschew, Claudia Geismann, Amke Caliebe, Carolin Knecht, Marianne Nygaard, Nandini Badarinarayan, Abdou ElSharawy, Sandra May, Anne Luzius, Guillermo G. Torres, Marlene Jentzsch, Michael Forster, Robert Häsler, Kathrin Pallauf, Wolfgang Lieb, Céline Derbois, Pilar Galan, Dmitriy Drichel, Alexander Arlt, Andreas Till, Ben Krause-Kyora, Gerald Rimbach, Hélène Blanché, Jean-François Deleuze, Lene Christiansen, Kaare Christensen, Michael Nothnagel, Philip Rosenstiel, Stefan Schreiber, Andre Franke, Susanne Sebens, Almut Nebel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
FOXO3 is one of the few established longevity genes. Here, the authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and
Externí odkaz:
https://doaj.org/article/f1d90b23cde74314abd23e1b467785a0
Autor:
Friederike Flachsbart, Janina Dose, Liljana Gentschew, Claudia Geismann, Amke Caliebe, Carolin Knecht, Marianne Nygaard, Nandini Badarinarayan, Abdou ElSharawy, Sandra May, Anne Luzius, Guillermo G. Torres, Marlene Jentzsch, Michael Forster, Robert Häsler, Kathrin Pallauf, Wolfgang Lieb, Céline Derbois, Pilar Galan, Dmitriy Drichel, Alexander Arlt, Andreas Till, Ben Krause-Kyora, Gerald Rimbach, Hélène Blanché, Jean-François Deleuze, Lene Christiansen, Kaare Christensen, Michael Nothnagel, Philip Rosenstiel, Stefan Schreiber, Andre Franke, Susanne Sebens, Almut Nebel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
The original version of this Article contained an error in the spelling of the author Robert Häsler, which was incorrectly given as Robert Häesler. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/3a301166958a4d53891142c0787acc2f
Autor:
Susanne Sebens, Marlene Jentzsch, Kaare Christensen, Michael Nothnagel, Liljana Gentschew, Sandra May, Stefan Schreiber, Hélène Blanché, Pilar Galan, Alexander Arlt, Amke Caliebe, Guillermo G. Torres, Abdou ElSharawy, Lene Christiansen, Friederike Flachsbart, Gerald Rimbach, Wolfgang Lieb, Anne Luzius, Carolin Knecht, Robert Häsler, Marianne Nygaard, Nandini Badarinarayan, Andre Franke, Jean-François Deleuze, Céline Derbois, Kathrin Pallauf, Claudia Geismann, Michael Forster, Andreas Till, Almut Nebel, Dmitriy Drichel, Janina Dose, Philip Rosenstiel, Ben Krause-Kyora
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
Flachsbart, F, Dose, J, Gentschew, L, Geismann, C, Caliebe, A, Knecht, C, Nygaard, M, Badarinarayan, N, ElSharawy, A, May, S, Luzius, A, Torres, G G, Jentzsch, M, Forster, M, Häsler, R, Pallauf, K, Lieb, W, Derbois, C, Galan, P, Drichel, D, Arlt, A, Till, A, Krause-Kyora, B, Rimbach, G, Blanché, H, Deleuze, J-F, Christiansen, L, Christensen, K, Nothnagel, M, Rosenstiel, P, Schreiber, S, Franke, A, Sebens, S & Nebel, A 2018, ' Publisher Correction : Identification and characterization of two functional variants in the human longevity gene FOXO3 ', Nature Communications, vol. 9, 320 . https://doi.org/10.1038/s41467-018-02842-8
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
Flachsbart, F, Dose, J, Gentschew, L, Geismann, C, Caliebe, A, Knecht, C, Nygaard, M, Badarinarayan, N, ElSharawy, A, May, S, Luzius, A, Torres, G G, Jentzsch, M, Forster, M, Häsler, R, Pallauf, K, Lieb, W, Derbois, C, Galan, P, Drichel, D, Arlt, A, Till, A, Krause-Kyora, B, Rimbach, G, Blanché, H, Deleuze, J-F, Christiansen, L, Christensen, K, Nothnagel, M, Rosenstiel, P, Schreiber, S, Franke, A, Sebens, S & Nebel, A 2018, ' Publisher Correction : Identification and characterization of two functional variants in the human longevity gene FOXO3 ', Nature Communications, vol. 9, 320 . https://doi.org/10.1038/s41467-018-02842-8
FOXO3 is consistently annotated as a human longevity gene. However, functional variants and underlying mechanisms for the association remain unknown. Here, we perform resequencing of the FOXO3 locus and single-nucleotide variant (SNV) genotyping in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55f6a9e66638237bde6135f16bcc204
https://doi.org/10.1038/s41467-018-02842-8
https://doi.org/10.1038/s41467-018-02842-8
Autor:
Susanne Sebens, Wolfgang Lieb, Anne Luzius, Carolin Knecht, Marianne Nygaard, Nandini Badarinarayan, Robert Häsler, Sandra May, Marlene Jentzsch, Gerald Rimbach, Friederike Flachsbart, Andre Franke, Claudia Geismann, Almut Nebel, Stefan Schreiber, Dmitriy Drichel, Céline Derbois, Ben Krause-Kyora, Michael Nothnagel, Amke Caliebe, Hélène Blanché, Guillermo G. Torres, Kaare Christensen, Lene Christiansen, Michael Forster, Liljana Gentschew, Jean-François Deleuze, Andreas Till, Philip Rosenstiel, Alexander Arlt, Janina Dose, Abdou ElSharawy, Pilar Galan, Kathrin Pallauf
Publikováno v:
Flachsbart, F, Dose, J, Gentschew, L, Geismann, C, Caliebe, A, Knecht, C, Nygaard, M, Badarinarayan, N, ElSharawy, A, May, S, Luzius, A, Torres, G G, Jentzsch, M, Forster, M, Häesler, R, Pallauf, K, Lieb, W, Derbois, C, Galan, P, Drichel, D, Arlt, A, Till, A, Krause-Kyora, B, Rimbach, G, Blanché, H, Deleuze, J-F, Christiansen, L, Christensen, K, Nothnagel, M, Rosenstiel, P, Schreiber, S, Franke, A, Sebens, S & Nebel, A 2017, ' Identification and characterization of two functional variants in the human longevity gene FOXO3 ', Nature Communications, vol. 8, 2063 . https://doi.org/10.1038/s41467-017-02183-y
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications (8), 1-12. (2017)
Nature Communications
Nature Communications, 2017, 8, pp.1-12. ⟨10.1038/s41467-017-02183-y⟩
Nature Communications, Nature Publishing Group, 2017, 8, pp.1-12. ⟨10.1038/s41467-017-02183-y⟩
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications (8), 1-12. (2017)
Nature Communications
Nature Communications, 2017, 8, pp.1-12. ⟨10.1038/s41467-017-02183-y⟩
Nature Communications, Nature Publishing Group, 2017, 8, pp.1-12. ⟨10.1038/s41467-017-02183-y⟩
FOXO3 is consistently annotated as a human longevity gene. However, functional variants and underlying mechanisms for the association remain unknown. Here, we perform resequencing of the FOXO3 locus and single-nucleotide variant (SNV) genotyping in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952cb2aeffa773f27d84fba1061e00c4
https://findresearcher.sdu.dk:8443/ws/files/129679489/Identification_and_characterization_of_two_functional_variants_in_the_human_longevity_gene_FOXO3.pdf
https://findresearcher.sdu.dk:8443/ws/files/129679489/Identification_and_characterization_of_two_functional_variants_in_the_human_longevity_gene_FOXO3.pdf
Autor:
Martina Müller-Nurasyid, Amke Caliebe, Céline Derbois, Friederike Flachsbart, Carsten Büning, Anette Peters, Pilar Galan, Per Hoffmann, Marianne Nygaard, Stephan Brand, Stefan Schreiber, Femke-Anouska Heinsen, Almut Nebel, Andre Franke, Markus M. Nöthen, Wolfgang Lieb, Liljana Gentschew, Kaare Christensen, David Ellinghaus, Lene Christiansen, Hélène Blanché, Konstantin Strauch, Jean-François Deleuze
Publikováno v:
Flachsbart, F, Ellinghaus, D, Gentschew, L, Heinsen, F-A, Caliebe, A, Christiansen, L, Nygaard, M, Christensen, K, Blanché, H, Deleuze, J-F, Derbois, C, Galan, P, Büning, C, Brand, S, Peters, A, Strauch, K, Müller-Nurasyid, M, Hoffmann, P, Nöthen, M M, Lieb, W, Franke, A, Schreiber, S & Nebel, A 2016, ' Immunochip analysis identifies association of the RAD50/IL13 region with human longevity ', Aging Cell, vol. 15, no. 3, pp. 585-588 . https://doi.org/10.1111/acel.12471
Aging Cell
Aging Cell, Wiley Open Access, 2016, 15 (3), pp.585-588. ⟨10.1111/acel.12471⟩
Aging Cell 15, 585-588 (2016)
Aging Cell, 2016, 15 (3), pp.585-588. ⟨10.1111/acel.12471⟩
Aging Cell 3 (15), 585-588. (2016)
Aging Cell
Aging Cell, Wiley Open Access, 2016, 15 (3), pp.585-588. ⟨10.1111/acel.12471⟩
Aging Cell 15, 585-588 (2016)
Aging Cell, 2016, 15 (3), pp.585-588. ⟨10.1111/acel.12471⟩
Aging Cell 3 (15), 585-588. (2016)
Human longevity is characterized by a remarkable lack of confirmed genetic associations. Here, we report on the identification of a novel locus for longevity in the RAD50/IL13 region on chromosome 5q31.1 using a combined European sample of 3208 long-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cb308913b126fa9a168182822bdaa3
https://findresearcher.sdu.dk:8443/ws/files/128924254/Immunochip_analysis_identifies_association.pdf
https://findresearcher.sdu.dk:8443/ws/files/128924254/Immunochip_analysis_identifies_association.pdf
Autor:
Karen S. Bishop, Wen Jiun Lam, Dug Yeo Han, Nishi Karunasinghe, Angharad R. Morgan, Liljana Gentschew, Alan G. Fraser, Bobbi Campbell, Lynnette R. Ferguson
Publikováno v:
Nutrients; Volume 4; Issue 9; Pages: 1247-1259
Nutrients
Nutrients, Vol 4, Iss 9, Pp 1247-1259 (2012)
Nutrients
Nutrients, Vol 4, Iss 9, Pp 1247-1259 (2012)
New Zealand has one of the highest incidence rates of Crohn's Disease (CD), whilst the serum selenium status of New Zealanders is amongst the lowest in the world. A prospective case-control study in Auckland, New Zealand considered serum selenium as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cb1408b3626d49aee9ab6eb204bb0f
https://doi.org/10.3390/nu4091247
https://doi.org/10.3390/nu4091247
Autor:
Stefan Schreiber, Carolin Däumer, Amke Caliebe, Liljana Gentschew, Michael Möller, Friederike Flachsbart, Almut Nebel, Rabea Kleindorp, Michael Krawczak
Publikováno v:
European Journal of Human Genetics; Vol 21
Our study demonstrates that the genetic investigation of forkhead box O3A gene (FOXO3A), a validated human longevity gene, is greatly hampered by the fact that its exonic regions have 99% sequence homology with the FOXO3B pseudogene. If unaccounted f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4bf68e72c679be74114d0acb8bc045
https://doi.org/10.1038/ejhg.2012.83
https://doi.org/10.1038/ejhg.2012.83
Publikováno v:
Advanced Nutrition and Dietetics in Gastroenterology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9d71483e54b4c57873f3af9f846af27
https://doi.org/10.1002/9781118872796.ch3.12
https://doi.org/10.1002/9781118872796.ch3.12
Autor:
Friederike Flachsbart, Liljana Gentschew, Almut Nebel, Rabea Kleindorp, Stefan Schreiber, Nandini Badarinarayan
Publikováno v:
Biogerontology; Vol 14
The role of superoxide dismutases (SODs) in aging and oxidative stress regulation has been widely studied and there is growing evidence that imbalances in these processes influence lifespan in several species. In humans, genetic polymorphisms in SOD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed651697184511c4df521ed0c133a9c
https://pubmed.ncbi.nlm.nih.gov/24146173
https://pubmed.ncbi.nlm.nih.gov/24146173
Publikováno v:
Molecular nutritionfood research. 56(4)
Inflammatory bowel diseases (IBDs), Crohn's disease (CD), and ulcerative colitis (UC) are chronic inflammatory conditions, which are increasing in incidence, prevalence, and severity, in many countries. While there is genetic susceptibility to IBD, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f43677eb49f0759e64944a3540e637
https://pubmed.ncbi.nlm.nih.gov/22495981
https://pubmed.ncbi.nlm.nih.gov/22495981