A Comprehensive Gene Expression Analysis of Resistance Formation upon Metronomic Cyclophosphamide Therapy

Autor: Rebekka Kubisch, Lilja Meissner, Stefan Krebs, Helmut Blum, Michael Günther, Andreas Roidl, Ernst Wagner

Publikováno v: Translational Oncology, Vol 6, Iss 1, Pp 1IN1-9IN3 (2013)

Resistance formation is one of the major hurdles in cancer therapy. Metronomic anti-angiogenic treatment of xenografted prostate cancer tumors in severe combined-immunodeficiency (SCID) mice with cyclophosphamide (CPA) results in the appearance of re

Externí odkaz: https://doaj.org/article/c407f0672fbf47089a1ec615baafaeaa

The choroid plexus is a key cerebral invasion route for T cells after stroke

Autor: Gaby Enzmann, Ruiyao Cai, Joan Montaner, Corinne Benakis, Ivana Lazarevic, Britta Engelhardt, Nikolaus Plesnila, Denis Vivien, Sabine Liebscher, Xiang Mao, Christof Haffner, Gemma Llovera, Alireza Ghasemigharagoz, Lilja Meissner, Rainer Malik, Arthur Liesz, Thomas Arzberger, Ali Ertürk

Publikováno v: Llovera, Gemma; Benakis, Corinne; Enzmann, Gaby; Cai, Ruiyao; Arzberger, Thomas; Ghasemigharagoz, Alireza; Mao, Xiang; Malik, Rainer; Lazarevic, Ivana; Liebscher, Sabine; Ertürk, Ali; Meissner, Lilja; Vivien, Denis; Haffner, Christof; Plesnila, Nikolaus; Montaner, Joan; Engelhardt, Britta; Liesz, Arthur (2017). The choroid plexus is a key cerebral invasion route for T cells after stroke. Acta neuropathologica, 134(6), pp. 851-868. Springer 10.1007/s00401-017-1758-y

Neuroinflammation contributes substantially to stroke pathophysiology. Cerebral invasion of peripheral leukocytes-particularly T cells-has been shown to be a key event promoting inflammatory tissue damage after stroke. While previous research has foc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c23f17ea6bded6753ef622deb980c8

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons

Autor: H-G. Knaus, Hans Zischka, Nikolaus Plesnila, Matthias Höllerhage, Carsten Culmsee, Günter U. Höglinger, A de Andrade, Lilja Meissner, Amalia M. Dolga, P Christophersen

Publikováno v: Cell Death & Disease
Cell death & disease 5(1), e999-e999 (2014). doi:10.1038/cddis.2013.530

Small-conductance Ca(2+)-activated K(+) channel activation is an emerging therapeutic approach for treatment of neurological diseases, including stroke, amyotrophic lateral sclerosis and schizophrenia. Our previous studies showed that activation of S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf9e3f82cac3b3215981b433de92087
https://pubmed.ncbi.nlm.nih.gov/24434522

Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles

Autor: Doortje Caroline Engel, Henryk Barthel, Nikolaus Plesnila, Serge C. Thal, Seong-Woong Kim, Klas Blomgren, Alexander Drzezga, Rakesh P. Patel, Nicole A. Terpolilli, Vilia Zeisig, Benjamin Klaesner, Lilja Meissner, Hiroharu Kataoka, Johannes Boltze, Susanne M. Schwarzmaier, Bjoern Nitzsche, Wolfgang M. Kuebler, Uta Mamrak, Changlian Zhu

Publikováno v: Circulation research. 110(5)

Rationale: Stroke is the third most common cause of death in industrialized countries. The main therapeutic target is the ischemic penumbra, potentially salvageable brain tissue that dies within the first few hours after blood flow cessation. Hence,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd37da3cb246442775d5d22be7ce811
https://pubmed.ncbi.nlm.nih.gov/22383706