Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Liliya Tyutyunyk‐Massey"'
1
Akademický článek
NOXA expression is downregulated in human breast cancer undergoing incomplete pathological response and senescence after neoadjuvant chemotherapy
Autor: Sofian Al Shboul, Mohammed El-Sadoni, Ahmad Alhesa, Nisreen Abu Shahin, Dua Abuquteish, Ola Abu Al Karsaneh, Elham Alsharaiah, Mohammad A. Ismail, Liliya Tyutyunyk-Massey, Moureq R. Alotaibi, Victoria Neely, Hisashi Harada, Tareq Saleh
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Neoadjuvant chemotherapy (NAC) is a frequently utilized approach to treat locally advanced breast cancer, but, unfortunately, a subset of tumors fails to undergo complete pathological response. Apoptosis and therapy-induced senescence (TIS)
Externí odkaz: https://doaj.org/article/5d73956c379a445b81a893da313bf94f
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2
Akademický článek
A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment
Autor: Cheng-Hsin Wei, Lu Huang, Blair Kreh, Xiuxia Liu, Liliya Tyutyunyk-Massey, Masanori Kawakami, Zibo Chen, Mi Shi, Serguei Kozlov, King C. Chan, Thorkell Andresson, Mary Carrington, Vidyasagar Vuligonda, Martin E. Sanders, Amir Horowitz, Patrick Hwu, Weiyi Peng, Ethan Dmitrovsky, Xi Liu
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract All-trans-retinoic acid (ATRA), the retinoic acid receptors (RARs) agonist, regulates cell growth, differentiation, immunity, and survival. We report that ATRA-treatment repressed cancer growth in syngeneic immunocompetent, but not immunodef
Externí odkaz: https://doaj.org/article/3a6d32daebaf4a6c91b60abe62aa93bd
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3
Akademický článek
The BET inhibitor/degrader ARV-825 prolongs the growth arrest response to Fulvestrant + Palbociclib and suppresses proliferative recovery in ER-positive breast cancer
Autor: Ryan M. Finnegan, Ahmed M. Elshazly, Nipa H. Patel, Liliya Tyutyunyk-Massey, Tammy H. Tran, Vishnu Kumarasamy, Erik S. Knudsen, David A. Gewirtz
Publikováno v: Frontiers in Oncology, Vol 12 (2023)
Anti-estrogens or aromatase inhibitors in combination with cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are the current standard of care for estrogen receptor-positive (ER+) Her-2 negative metastatic breast cancer. Although these combination t
Externí odkaz: https://doaj.org/article/894a189ccef24ff08e4d0a659547be7f
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4
Akademický článek
Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐XL–BAX interaction
Autor: Tareq Saleh, Valerie J. Carpenter, Liliya Tyutyunyk‐Massey, Graeme Murray, Joel D. Leverson, Andrew J. Souers, Moureq R. Alotaibi, Anthony C. Faber, Jason Reed, Hisashi Harada, David A. Gewirtz
Publikováno v: Molecular Oncology, Vol 14, Iss 10, Pp 2504-2519 (2020)
Tumor cells undergo senescence in response to both conventional and targeted cancer therapies. The induction of senescence in response to cancer therapy can contribute to unfavorable patient outcomes, potentially including disease relapse. This possi
Externí odkaz: https://doaj.org/article/b1ca93626c5148b4a9daf8f17d95e358
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