Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Liliya R. Novototskaya"'
Autor:
Natalia Fedtsova, Elena A. Komarova, Kellee F. Greene, Liliya R. Novototskaya, Ivan Molodtsov, Craig M. Brackett, Evguenia Strom, Anatoli S. Gleiberman, Alexander N. Shakhov, Andrei V. Gudkov
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Abstract Transplantation of bone marrow (BM) is made possible by the differential sensitivity of its stromal and hematopoietic components to preconditioning by radiation and/or chemotherapeutic drugs. These genotoxic treatments eliminate host hematop
Externí odkaz:
https://doaj.org/article/567e32f8c63e48f8b13d02edbbb27399
Autor:
Kellee F. Greene, Anatoli S. Gleiberman, Alexander N. Shakhov, Elena A. Komarova, Natalia Fedtsova, Evguenia Strom, Craig M. Brackett, Andrei V. Gudkov, Ivan Molodtsov, Liliya R. Novototskaya
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Transplantation of bone marrow (BM) is made possible by the differential sensitivity of its stromal and hematopoietic components to preconditioning by radiation and/or chemotherapeutic drugs. These genotoxic treatments eliminate host hematopoietic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73009fdcba6cd3a55b4d5176715b514e
http://europepmc.org/articles/PMC8154997
http://europepmc.org/articles/PMC8154997
Autor:
Liliya R. Novototskaya, K Green, Patricia Stanhope Baker, Costakis Frangou, Andrei L. Osterman, A Eroshkin, Andrei V. Gudkov, Andrei P. Komarov, A A Chenchick, Elena A. Komarova
Publikováno v:
Cell Death & Disease
shRNA-mediated gene-silencing technology paired with cell-based functional readouts reveals potential targets directly, providing an opportunity to identify drugs against the target without knowing the precise role of the target in the pathophysiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9cdb45cb348435da7a2cf8f3190156
https://pubmed.ncbi.nlm.nih.gov/26986512
https://pubmed.ncbi.nlm.nih.gov/26986512
Autor:
Liliya R. Novototskaya, Elena A. Komarova, Olga B. Chernova, Geraldine M. Paszkiewicz, Andrei V. Gudkov, Mikhail V. Blagosklonny, Marina P. Antoch, Olga V. Leontieva
Publikováno v:
Aging (Albany NY)
The TOR (Target of Rapamycin) pathway accelerates cellular and organismal aging. Similar to rapamycin, p53 can inhibit the mTOR pathway in some mammalian cells. Mice lacking one copy of p53 (p53+/− mice) have an increased cancer incidence and a sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1706ea6ef9422dc4aa99bf81b2a3d5e3
https://doi.org/10.18632/aging.100498
https://doi.org/10.18632/aging.100498
Autor:
Liliya R. Novototskaya, Jelena O. Shneyder, Andrei V. Gudkov, Katerina I. Leonova, Marina P. Antoch, Pavel G. Komarov, Illia A. Toshkov, Elena A. Komarova
Publikováno v:
Cell Cycle. 9:1434-1443
It has been shown that genetic inhibition of p53 leads to enhanced proliferation of hematopoietic stem cells (HSCs). This could, in theory, contribute to the increased frequency of tumor development observed in p53-deficient mice and humans. In our p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91226b36c2c3fadd5eeba154cd1f8f0
https://doi.org/10.4161/cc.9.7.11508
https://doi.org/10.4161/cc.9.7.11508
Autor:
Ganes C. Sen, Leonid Brodsky, Alex Chenchik, Elena A. Komarova, Andrei V. Gudkov, Mahadeb Pal, Liliya R. Novototskaya, Katerina I. Leonova, Brittany C. Lipchick
Publikováno v:
Cell Cycle
Large parts of mammalian genomes are transcriptionally inactive and enriched with various classes of interspersed and tandem repeats. Here we show that the tumor suppressor protein p53 cooperates with DNA methylation to maintain silencing of a large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b432d833de33781e1df0ac833632d3aa
https://doi.org/10.1073/pnas.1216922110
https://doi.org/10.1073/pnas.1216922110
Autor:
Liliya R. Novototskaya, Zhou Wang, Andrei V. Gudkov, Andrei Purmal, Naoyuki G. Saito, Mairead Commane, Kellee F. Greene, Katerina Gurova
Publikováno v:
Cancer Research. 70:LB-166
Technological advances in radiation therapy have greatly improved our ability to deliver a precise dose of radiation to a defined volumetric target with high accuracy. However, local recurrence of cancer, especially that in the previously irradiated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::255ec2ec7f52c10ee53a12c2f08ad779
https://doi.org/10.1158/1538-7445.am10-lb-166
https://doi.org/10.1158/1538-7445.am10-lb-166