Zobrazeno 1 - 10 of 48 pro vyhledávání: '"Liliane Goetsch"'
1
A novel antagonist anti-cMet antibody with antitumor activities targeting both ligand-dependent and ligand-independent c-Met receptors
Autor: Liliane Goetsch, Alain Beck, Christian Bailly, Matthieu Broussas, Alexandra Gonzalez, Jean-François Haeuw, Alain Robert, Charlotte Beau-Larvor, Nicolas Boute, Nathalie Corvaia, Thierry Champion
Publikováno v: International Journal of Cancer. 139:1851-1863
c-Met is a prototypic member of a sub-family of RTKs. Inappropriate c-Met activation plays a crucial role in tumor formation, proliferation and metastasis. Using a key c-Met dimerization assay, a set of 12 murine whole IgG1 monoclonal antibodies was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65322a6db3b2f48bc58243d0e42f7c7f
https://doi.org/10.1002/ijc.30174
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2
Strategies and challenges for the next generation of antibody-drug conjugates
Autor: Liliane Goetsch, Charles Dumontet, Alain Beck, Nathalie Corvaia
Publikováno v: Nature reviews. Drug discovery. 16(5)
Antibody-drug conjugates (ADCs) are one of the fastest growing classes of oncology therapeutics. After half a century of research, the approvals of brentuximab vedotin (in 2011) and trastuzumab emtansine (in 2013) have paved the way for ongoing clini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16d156f1d90b17e4255b5222363e587
https://pubmed.ncbi.nlm.nih.gov/28303026
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3
A New Anti-CXCR4 Antibody That Blocks the CXCR4/SDF-1 Axis and Mobilizes Effector Cells
Autor: Alain Beck, Charlotte Beau-Larvor, Christine Klinguer-Hamour, Liliane Goetsch, Sven Berger, Matthieu Broussas, Thomas Matthes, Thierry Champion, Alain Robert, Nathalie Corvaia, Nicolas Boute, Barbara Akla, Christian Bailly, Jean-François Haeuw, Charles Dumontet
Publikováno v: Molecular Cancer Therapeutics, Vol. 15, No 8 (2016) pp. 1890-1899
Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, 2016, 15, pp.1890-1899. ⟨10.1158/1535-7163.MCT-16-0041⟩
Molecular Cancer Therapeutics, American Association for Cancer Research, 2016, 15, pp.1890-1899. ⟨10.1158/1535-7163.MCT-16-0041⟩
The type IV C-X-C-motif chemokine receptor (CXCR4) is expressed in a large variety of human cancers, including hematologic malignancies, and this receptor and its ligand, stromal cell–derived factor-1 (SDF-1), play a crucial role in cancer progress
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3899e858a708815717c620ef377724
https://archive-ouverte.unige.ch/unige:88986
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4
7th Cancer Scientific Forum of the Cancéropôle Lyon Auvergne Rhône-Alpes
Autor: Petrus J. Pauwels, Bertrand Coiffier, Alain Beck, Christian Klein, Liliane Goetsch, Charles Dumontet, Janice M. Reichert, Beverly A. Teicher, Nathalie Corvaia
Publikováno v: mAbs. 4:434-444
The Innovative Approaches in Anti-Cancer Monoclonal Antibodies meeting, held on March 20, 2012 in Lyon, was organized by Canceropole Lyon Auvergne-Rhone-Alps in partnership with the French competitiveness cluster Lyonbiopole. CLARA is one of the seve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee5679554d7b0bad7e1891813c7cf9f7
https://doi.org/10.4161/mabs.20869
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6
Selection criteria for c-Met-targeted therapies: emerging evidence for biomarkers
Autor: Liliane Goetsch, Véronique Caussanel
Publikováno v: Biomarkers in Medicine. 4:149-170
Extensive development of targeted therapies emphasize the critical need for biomarkers and major efforts have been engaged to identify screening, prognostic, stratification and therapy-monitoring markers. One of the challenges in translating preclini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6978c07e6dd23f2fd2ab4de41ffc25
https://doi.org/10.2217/bmm.09.67
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7
Anticorps et tumeurs solides
Autor: Alexandre Bodmer, Liliane Goetsch, Nathalie Corvaia, Laurence Favet, Christian Bailly, Pierre-Yves Dietrich
Publikováno v: médecine/sciences. 25:1090-1098
Recent biotechnological advances allowed the development of a novel class of anti-cancer drugs called monoclonal antibodies (mAb). To illustrate the potential of these new agents, two mAbs used in daily practice (i.e., trastuzumab and cetuximab) and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71ef232024160261ea8c6d76335add49
https://doi.org/10.1051/medsci/200925121090
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8
Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor
Autor: Nathalie Corvaia, Joëlle Dupont, Alexandra Gonzalez, Matthieu Broussas, Liliane Goetsch, Aline Blaecke, Mathilde Fournier
Publikováno v: International Journal of Cancer
International Journal of Cancer, Wiley, 2009, 124 (10), pp.2281-2293. ⟨10.1002/ijc.24186⟩
International audience; IGF-1 receptor (IGF-1R) plays a key role in the development of numerous tumors. Blockade of IGF-1R axis using monoclonal antibodies constitutes an interesting approach to inhibit tumor growth. We have previously shown that VC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98ccbdc8e79e7a02c47e1a709eea1cf
https://doi.org/10.1002/ijc.24186
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9
Peptides as tools and drugs for immunotherapies
Autor: Thien Ngoc Nguyen, Marie-Claire Bussat, Thierry Champion, Thierry Wurch, Jean-François Haeuw, Alain Beck, Liliane Goetsch, Christine Klinguer-Hamour, Alain Milon, Alain Van Dorsselaer, Nathalie Corvaia, Masae Sugawara
Publikováno v: Journal of Peptide Science. 13:588-602
Peptides are essential tools for discovery and pre-clinical and pharmaceutical development of viral and cancer vaccines (‘active immunotherapies’) as well as for therapeutic antibodies (‘passive immunotherapies’). They help to trigger and ana
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5529a7131d92d130c980dfc016f7b8a1
https://doi.org/10.1002/psc.852
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10
A novel antagonist anti-cMet antibody with antitumor activities targeting both ligand-dependent and ligand-independent c-Met receptors
Autor: Alexandra, Gonzalez, Matthieu, Broussas, Charlotte, Beau-Larvor, Jean-François, Haeuw, Nicolas, Boute, Alain, Robert, Thierry, Champion, Alain, Beck, Christian, Bailly, Nathalie, Corvaïa, Liliane, Goetsch
Publikováno v: International journal of cancer. 139(8)
c-Met is a prototypic member of a sub-family of RTKs. Inappropriate c-Met activation plays a crucial role in tumor formation, proliferation and metastasis. Using a key c-Met dimerization assay, a set of 12 murine whole IgG1 monoclonal antibodies was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d50bf486e06f8bc563e3636932fcfd0
https://pubmed.ncbi.nlm.nih.gov/27144973
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