Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Liliane C. Broye"'
Autor:
Gaylor Boulay, Liliane C. Broye, Rui Dong, Sowmya Iyer, Rajendran Sanalkumar, Yu-Hang Xing, Rémi Buisson, Shruthi Rengarajan, Beverly Naigles, Benoît Duc, Angela Volorio, Mary E. Awad, Raffaele Renella, Ivan Chebib, G. Petur Nielsen, Edwin Choy, Gregory M. Cote, Lee Zou, Igor Letovanec, Ivan Stamenkovic, Miguel N. Rivera, Nicolò Riggi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract EWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-WT
Externí odkaz:
https://doaj.org/article/fd00253648764577aeb52739a580a6a3
Autor:
Emely Möller, Viviane Praz, Sanalkumar Rajendran, Rui Dong, Alexandra Cauderay, Yu-Hang Xing, Lukuo Lee, Carlo Fusco, Liliane C. Broye, Luisa Cironi, Sowmya Iyer, Shruthi Rengarajan, Mary E. Awad, Beverly Naigles, Igor Letovanec, Nicola Ormas, Giovanna Finzi, Stefano La Rosa, Fausto Sessa, Ivan Chebib, G. Petur Nielsen, Antonia Digklia, Dimitrios Spentzos, Gregory M. Cote, Edwin Choy, Martin Aryee, Ivan Stamenkovic, Gaylor Boulay, Miguel N. Rivera, Nicolò Riggi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The relationship between cellular histogenesis and molecular phenotypes for the EWSR1- ATF1 fusion in clear cell sarcoma (CCS) requires further characterization. Here, the authors investigate the EWSR1-ATF1 gene regulation networks in CCS cell lines,
Externí odkaz:
https://doaj.org/article/1755fdc1556a4ae2aea83d025041fcd5
Autor:
Frank B. Gertler, James E. Bear, Patricia J. Keely, Douglas A. Lauffenburger, Richard O. Hynes, Kari B. Wisinski, Michael J. Cima, Robert Langer, Duanduan Ma, Charlie Whittaker, Sreeja B. Asokan, John M. Lamar, Daisy Riquelme, Jeff Wyckoff, Bruna C. Guido, Liliane C. Broye, Tatsiana Kosciuk, Oliver Jonas, Madeleine J. Oudin
Supplementary Figure S5. Mena isoform expression does not affect Integrin alphav, beta1 or FAK levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eff0ee4083e33a04f07af4a23a9cba3
https://doi.org/10.1158/2159-8290.22531394
https://doi.org/10.1158/2159-8290.22531394
Autor:
Frank B. Gertler, James E. Bear, Patricia J. Keely, Douglas A. Lauffenburger, Richard O. Hynes, Kari B. Wisinski, Michael J. Cima, Robert Langer, Duanduan Ma, Charlie Whittaker, Sreeja B. Asokan, John M. Lamar, Daisy Riquelme, Jeff Wyckoff, Bruna C. Guido, Liliane C. Broye, Tatsiana Kosciuk, Oliver Jonas, Madeleine J. Oudin
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cccb7933131f12f4e83628ea9829270
https://doi.org/10.1158/2159-8290.22531409.v1
https://doi.org/10.1158/2159-8290.22531409.v1
Autor:
Emely Möller, Viviane Praz, Sanalkumar Rajendran, Rui Dong, Alexandra Cauderay, Yu-Hang Xing, Lukuo Lee, Carlo Fusco, Liliane C. Broye, Luisa Cironi, Sowmya Iyer, Shruthi Rengarajan, Mary E. Awad, Beverly Naigles, Igor Letovanec, Nicola Ormas, Giovanna Finzi, Stefano La Rosa, Fausto Sessa, Ivan Chebib, G. Petur Nielsen, Antonia Digklia, Dimitrios Spentzos, Gregory M. Cote, Edwin Choy, Martin Aryee, Ivan Stamenkovic, Gaylor Boulay, Miguel N. Rivera, Nicolò Riggi
Publikováno v:
Nature communications, vol. 13, no. 1, pp. 2267
Oncogenic fusion proteins generated by chromosomal translocations play major roles in cancer. Among them, fusions between EWSR1 and transcription factors generate oncogenes with powerful chromatin regulatory activities, capable of establishing comple
Autor:
Raffaele Renella, Tugba Keskin, Mario L. Suvà, Manuel Diezi, Stéphane Cherix, Liliane C. Broye, Igor Letovanec, Stefano La Rosa, Paolo Provero, Ivan Stamenkovic, Elizabeth M. Perez, Beatrice Rucci, Patricia Martin, Carlo Fusco, Sandrine Cornaz-Buros, Nicolo Riggi, Katarina Cisarova
Publikováno v:
Science advances, vol. 7, no. 27, pp. eabf9394
Targeting of the most aggressive tumor cell subpopulations is key for effective management of most solid malignancies. However, the metastable nature of tumor heterogeneity, which allows cells to transition between strong and weak tumorigenic phenoty
Autor:
Nikhil Wagle, Peter K. Sorger, Angela Volorio, Christophe H. Georgescu, Nicolo Riggi, Liliane C. Broye, Lan Nguyen, Ivan Chebib, Brian J. Haas, Nathan Mathewson, Johannes C. Melms, Marni E. Shore, Orit Rozenblatt-Rosen, Joseph M. Beechem, Cyril Neftel, Kai W. Wucherpfennig, Ofir Cohen, Jorge E. Buendia-Buendia, Michael Montemurro, Luisa Cironi, Shaolin Mei, Alyssa R. Richman, Igor Letovanec, Miguel Rivera, Mario L. Suvà, Michael S. Cuoco, Hannah R. Weisman, G. Petur Nielsen, Alex B. Haynes, Livnat Jerby-Arnon, Asa Segerstolpe, Cigall Kadoch, Christina C. Luo, John T. Mullen, Gaylor Boulay, Matthew J. McBride, Gregory M. Cote, Aviv Regev, Ravindra Mylvaganam, Benjamin Izar, Stéphane Cherix, Nicole Ortogero, Simon Gritsch, Danny Labes, Ivan Stamenkovic, Malika Sud, Tu Nguyen-Ngoc, Daniel R. Zollinger, Edwin Choy, Joseph M. Gurski
Publikováno v:
Nat Med
Synovial sarcoma (SyS) is an aggressive neoplasm driven by the SS18–SSX fusion, and is characterized by low T cell infiltration. Here, we studied the cancer–immune interplay in SyS using an integrative approach that combines single-cell RNA seque
Autor:
Joseph M. Beechem, Zollinger, Ivan Stamenkovic, Alyssa R. Richman, Christophe H. Georgescu, Angela Volorio, Peter K. Sorger, Joseph M. Gurski, Cyril Neftel, HR Weissman, Cuoco, Igor Letovanec, Gaylor Boulay, Nikhil Wagle, Orit Rozenblatt-Rosen, Danny Labes, Mario-Luca Suvà, Edwin Choy, Ivan Chebib, Ben Izar, Miguel Rivera, Christina C. Luo, Matthew J. McBride, Gregory M. Cote, Luisa Cironi, Brian J. Haas, Ofir Cohen, Shaolin Mei, Marni E. Shore, Jorge E. Buendia-Buendia, Aviv Regev, Nicolo Riggi, Livnat Jerby-Arnon, Stéphane Cherix, Cigall Kadoch, Ravindra Mylvaganam, John T. Mullen, Liliane C. Broye, Alex B. Haynes, Jc Melms, Gunnlaugur P. Nielsen, Lan T. Nguyen
Synovial sarcoma is an aggressive mesenchymal neoplasm, driven by the SS18-SSX fusion, and characterized by immunogenic antigens expression and exceptionally low T cell infiltration levels. To study the cancer-immune interplay in this disease, we pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15d6fa81c4c5eeaa50d0c025cdff1e6
Autor:
Ivan Stamenkovic, Miguel Rivera, Angela Volorio, Sowmya Iyer, Liliane C. Broye, Nicolo Riggi, Gaylor Boulay
Publikováno v:
Genes & development, vol. 32, no. 15-16, pp. 1008-1019
Various types of repetitive sequences are dysregulated in cancer. In Ewing sarcoma, the oncogenic fusion protein EWS-FLI1 induces chromatin features typical of active enhancers at GGAA microsatellite repeats, but the function of these sites has not b
Autor:
Ivan Stamenkovic, Rémi Buisson, Gaylor Boulay, Lee Zou, Nicolo Riggi, Matthew J. McBride, Sowmya Iyer, Beverly Naigles, Cigall Kadoch, Miguel Rivera, Mary E. Awad, Liliane C. Broye, Angela Volorio, Gabriel J. Sandoval, Shruthi Rengarajan
Publikováno v:
Cell, vol 171, iss 1
Alterations in transcriptional regulators can orchestrate oncogenic gene expression programs in cancer. Here, we show that the BRG1/BRM-associated factor (BAF) chromatin remodeling complex, which is mutated in over 20% of human tumors, interacts with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e017cbcbf5b227ad54a43870d103a8
https://escholarship.org/uc/item/2cw7w5tc
https://escholarship.org/uc/item/2cw7w5tc