The E144 residue of Scherffelia dubia centrin discriminates between the DNA repair protein XPC and the centrosomal protein Sfi1

Autor: Dora Grecu, Yves Blouquit, Liliane Assairi

Publikováno v: FEBS Open Bio, Vol 4, Iss C, Pp 33-42 (2014)

Centrins are members of the EF-hand family of calcium-binding proteins, which are highly conserved among eukaryotes. Centrins bind to several cellular targets, through a hydrophobic triad. However, the W1xxL4xxxL8 triad in XPC (Xeroderma Pigmentosum

Externí odkaz: https://doaj.org/article/af0ec7da072d4e87b260b2d86821dc19

8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode

Autor: Julie Paoletti, Gilles Labesse, Olivier Dussurget, Marie Anne Nahori, Liliane Assairi, Sylvie Pochet, Muriel Gelin, Valérie Huteau

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2016, 124, pp.1041-1056. ⟨10.1016/j.ejmech.2016.10.033⟩
European Journal of Medicinal Chemistry, 2016, 124, pp.1041-1056. ⟨10.1016/j.ejmech.2016.10.033⟩

Increased resistance of pathogens to existing antibiotics necessitates the search for novel targets to develop potent antimicrobials. Biosynthetic pathways of several cofactors important for bacterial growth, such as nicotinamide adenine dinucleotide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e165d3eae566bd9b213507978bbd048a
https://doi.org/10.1016/j.ejmech.2016.10.033

A chirality change in XPC- and Sfi1-derived peptides affects their affinity for centrin

Autor: Dora Grecu, Victor Paul Raj Irudayaraj, Jean-Maurice Mallet, Juan Martinez-Sanz, Liliane Assairi

Publikováno v: Neuropeptides
Neuropeptides, Elsevier, 2016, 78 (7), pp.77-86. ⟨10.1016/j.peptides.2016.02.005⟩
Neuropeptides, 2016, 78 (7), pp.77-86. ⟨10.1016/j.peptides.2016.02.005⟩

The Ca(2+)-binding protein centrin binds to a hydrophobic motif (W(1)xxL(4)xxxL(8)) included in the sequence of several cellular targets: XPC (xeroderma pigmentosum group C protein), Sfi1 (suppressor of fermentation-induced loss of stress resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d0e1800e7d49e46edf62f4cd6e9d1e
https://hal.archives-ouvertes.fr/hal-01306700

Structure, Dynamics and Thermodynamics of the Human Centrin 2/hSfi1 Complex

Autor: Geoffrey Bodenhausen, Liliane Assairi, Liliane Mouawad, Constantin T. Craescu, Daniel Abergel, Fatiha Kateb, Yves Blouquit, Juan Martinez-Sanz

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2010, 395 (1), pp.191-204. ⟨10.1016/j.jmb.2009.10.041⟩
Journal of Molecular Biology, Elsevier, 2010, 395 ((1)), pp.191-204. ⟨10.1016/j.jmb.2009.10.041⟩
Journal of Molecular Biology, 2010, 395 (1), pp.191-204. ⟨10.1016/j.jmb.2009.10.041⟩

Centrin, an EF-hand calcium-binding protein, has been shown to be involved in the duplication of centrosomes, and Sfi1 (Suppressor of fermentation-induced loss of stress resistance protein 1) is one of its centrosomal targets. There are three isoform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26d5cd8e20d3b28aa6fa7bc1e626b90
https://doi.org/10.1016/j.jmb.2009.10.041

Structure of Escherichia coli UMP Kinase Differs from That ofOther Nucleoside Monophosphate Kinases and Sheds New Light on EnzymeRegulation

Autor: Philippe Meyer, Liliane Assairi, Pierre Briozzo, Anne-Marie Gilles, Nathalie Joly, Octavian Barzu, Cécile Evrin

Publikováno v: Journal of Biological Chemistry. 280:25533-25540

Bacterial UMP kinases are essential enzymes involved in the multistep synthesis of nucleoside triphosphates. They are hexamers regulated by the allosteric activator GTP and inhibited by UTP. We solved the crystal structure of Escherichia coli UMP kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af881ec515c3b483a68c6bc9ecd120c
https://doi.org/10.1074/jbc.m501849200