ADME evaluation

Autor: Gilles Klopman, Liliana R. Stefan, Roustem D. Saiakhov

Publikováno v: European Journal of Pharmaceutical Sciences. 17:253-263

Purpose: To develop a computational method to rapidly evaluate human intestinal absorption, one of the drug properties included in the term ADME (Absorption, Distribution, Metabolism, Excretion). Poor ADME properties are the most important reason for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85672e4fb25216e8b676710f3277bd47
https://doi.org/10.1016/s0928-0987(02)00219-1

MeRNA: a Database of Metal Ion Binding Sites in RNA Structures

Autor: Aaron G. Levitan, Liliana R. Stefan, Stephen R. Holbrook, Rui Zhang, Donna K. Hendrix, Steven E. Brenner

Publikováno v: Stefan, Liliana R.; Zhang, Rui; Levitan, Aaron G.; Hendrix, Donna F.; Brenner, Steven E.; & Holbrook, Stephen R.(2005). MeRNA: a Database of Metal Ion Binding Sites in RNA Structures. Lawrence Berkeley National Laboratory. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/39b6350t
Nucleic Acids Research

Metal ions are essential for the folding of RNA into stable tertiary structures and for the catalytic activity of some RNA enzymes. To aid in the study of the roles of metal ions in RNA structural biology, we have created MeRNA (Metals in RNA), a com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98894d45eac357c4f5acfa91e1218e7
http://www.escholarship.org/uc/item/39b6350t

Multiple computer-automated structure evaluation model of the plasma protein binding affinity of diverse drugs.

Autor: Saiakhov, Roustem, Stefan, Liliana, Klopman, Gilles

Publikováno v: Perspectives in Drug Discovery & Design; Sep2000, Vol. 19 Issue 1, p133-155, 23p