Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Liliana Mendonça"'
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract Neurodegenerative diseases are characterized by extensive loss of function or death of brain cells, hampering the life quality of patients. Brain-targeted drug delivery is challenging, with a low success rate this far. Therefore, the applica
Externí odkaz:
https://doaj.org/article/b9a96212d3db4fe493515c82e381c731
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/2a9d6205006148c7ae5aec910765a848
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Externí odkaz:
https://doaj.org/article/bdd767871dbd4b0a8eb9bdf69f9cc614
Publikováno v:
Atención Primaria, Vol 54, Iss 11, Pp 102473- (2022)
Externí odkaz:
https://doaj.org/article/904c557032fd49afa1cb1e806e26e1cd
Autor:
Pedro M. Araújo, Ivan Viegas, Afonso D. Rocha, Auxiliadora Villegas, John G. Jones, Liliana Mendonça, Jaime A. Ramos, José A. Masero, José A. Alves
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Mechanisms underlying fat accumulation for long-distance migration are not fully understood. This is especially relevant in the context of global change, as many migrants are dealing with changes in natural habitats and associated food sourc
Externí odkaz:
https://doaj.org/article/9201803b0afb4eadbf848fbdf416e06c
Autor:
Mariana Conceição, Liliana Mendonça, Clévio Nóbrega, Célia Gomes, Pedro Costa, Hirokazu Hirai, João Nuno Moreira, Maria C. Lima, N. Manjunath, Luís Pereira de Almeida
Publikováno v:
Data in Brief, Vol 6, Iss , Pp 700-705 (2016)
In a clinical setting, where multiple administrations of the therapeutic agent are usually required to improve the therapeutic outcome, it is crucial to assess the immunogenicity of the administered nanoparticles. In this data work, we investigated t
Externí odkaz:
https://doaj.org/article/acd00237699d4218a437e7e121f618e1
Autor:
João Miguel Da Conceição Alves-Cruzeiro, Liliana Mendonça, Luis Pereira de Almeida, Clevio Nobrega
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant ataxia caused by an expansion of CAG repeats in the exon 1 of the gene ATXN2, conferring a gain of toxic function that triggers the appearance of the disease phenotype. SCA2 is characteriz
Externí odkaz:
https://doaj.org/article/9f3ac53661584564834415d6366f29a2
Autor:
Rebekah Koppenol, André Conceição, Adriana Marcelo, Sandra Tomé, José-Miguel Côdesso, Liliana Mendonça, Luis Pereira de Almeida, Carlos Matos, Clévio Nóbrega
Polylgutamine (polyQ) diseases are a group of neurodegenerative disorders caused by abnormal expansion of CAG repeat tracts in the codifying regions of nine, otherwise unrelated, genes. While the protein products of these genes are suggested to play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2d824972a405850a92f304bda104421
https://doi.org/10.21203/rs.3.rs-668663/v2
https://doi.org/10.21203/rs.3.rs-668663/v2
Autor:
Ana Sofia Silva, Joana Guimarães, Cláudia Sousa, Liliana Mendonça, Ricardo Soares-dos-Reis, Teresa Mendonça, Pedro Abreu, Lucinda Sequeira, Maria José Sá
Publikováno v:
Multiple Sclerosis and Related Disorders. 69:104370
Metabolic syndrome and multiple sclerosis [MS] share the presence of chronic inflammation in their pathogenic mechanisms. This study aimed to estimate the prevalence of metabolic syndrome parameters in MS and their association with disease disability
Autor:
Rebekah Koppenol, André Conceição, Inês T Afonso, Ricardo Afonso-Reis, Rafael G Costa, Sandra Tomé, Diogo Teixeira, Joana Pinto da Silva, José Miguel Côdesso, David V C Brito, Liliana Mendonça, Adriana Marcelo, Luís Pereira de Almeida, Carlos A Matos, Clévio Nóbrega
Publikováno v:
Brain : a journal of neurology.
Koppenol et al. show that overexpression of G3BP1 in cell models of SCA2 and SCA3 leads to a reduction in ataxin-2 and ataxin-3 aggregation. G3BP1 lentiviral delivery reduces motor deficits and neuropathology in preclinical models, suggesting that G3