Live Attenuated Salmonella enterica Expressing and Releasing Cell-Permeable Bax BH3 Peptide Through the MisL Autotransporter System Elicits Antitumor Activity in a Murine Xenograft Model of Human B Non-hodgkin's Lymphoma

Autor: Armando Alfredo Mateos-Chávez, Paola Muñoz-López, Elayne Irene Becerra-Báez, Luis Fernando Flores-Martínez, Diego Prada-Gracia, Liliana Marisol Moreno-Vargas, Guillermina Juliana Baay-Guzmán, Uriel Juárez-Hernández, Bibiana Chávez-Munguía, Lourdes Cabrera-Muñóz, Rosendo Luria-Pérez

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

The survival of patients with non-Hodgkin's lymphoma (NHL) has substantially improved with current treatments. Nevertheless, the appearance of drug-resistant cancer cells leads to patient relapse. It is therefore necessary to find new antitumor thera

Externí odkaz: https://doaj.org/article/b932eb9986744e69aac45f05c432c757

Molecular dynamics of the histamine H3 membrane receptor reveals different mechanisms of GPCR signal transduction

Autor: Leonardo David Herrera-Zúñiga, Liliana Marisol Moreno-Vargas, Luck Ballaud, José Correa-Basurto, Diego Prada-Gracia, David Pastré, Patrick A. Curmi, Jean Michel Arrang, Rachid C. Maroun

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)

In this work, we studied the mechanisms of classical activation and inactivation of signal transduction by the histamine H3 receptor, a 7-helix transmembrane bundle G-Protein Coupled Receptor through long-time-scale atomistic molecular dynamics simul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f97b73a1c20cb75df1a265b80065b5a0
http://europepmc.org/articles/PMC7547658

Application of computational methods for anticancer drug discovery, design, and optimization

Autor: Liliana Marisol Moreno-Vargas, Sara Huerta-Yépez, Diego Prada-Gracia

Publikováno v: Boletín Médico Del Hospital Infantil de México (English Edition)
Boletin Medico Del Hospital Infantil De Mexico
Boletín Médico del Hospital Infantil de México, Vol 73, Iss 6, Pp 411-423 (2016)

Developing a novel drug is a complex, risky, expensive and time-consuming venture. It is estimated that the conventional drug discovery process ending with a new medicine ready for the market can take up to 15 years and more than a billion USD. Fortu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56baa677262301b6d20300d9b463cdd4
http://europepmc.org/articles/PMC7154613

A complex view of GPCR signal transduction: Molecular dynamics of the histamine H3 membrane receptor

Autor: José Correa-Basurto, Liliana Marisol Moreno-Vargas, Luck Ballaud, Leonardo David Herrera-Zúñiga, Jean Michel Arrang, D Prada, Rachid C. Maroun, Patrick A. Curmi

In this work, we study the mechanisms of activation and inactivation of signal transduction by the histamine H3 receptor (H3R), an hepta-helical transmembrane bundle GPCR through extended molecular dynamics (MD) simulations of the receptor embedded i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d18f95a1534b39958890222ae9e730

Is there something else besides the proapoptotic AVPI-segment in the Smac/DIABLO protein?

Autor: Georgina Victoria-Acosta, Jorge Melendez-Zajgla, Liliana Marisol Moreno-Vargas, Gustavo Ulises Martinez-Ruiz, Marlet Martínez-Archundia

Publikováno v: Boletín Médico del Hospital Infantil de México, Vol 73, Iss 6, Pp 365-371 (2016)

In mammals, apoptosis is the main mechanism to eliminate unwanted cells, securing tissue homeostasis and consequently maintaining the health in the organism. Classically, apoptosis culminates with the activation of caspases, which are enzymes that di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13545ba7e7e82be3adeae6a280b49252