Výsledky vyhledávání - "Liliana M.E. Finocchiaro"

Therapeutic potential of the cytosine deaminase::uracil phosphoribosyl transferase/5-fluorocytosine suicide system for canine melanoma

Autor: Gerardo Claudio Glikin, Liliana M.E. Finocchiaro, Jesica B. Allende

Publikováno v: Veterinary and comparative oncologyREFERENCES. 20(2)

We tested the efficacy of a yeast cytosine deaminase::uracil phosphoribosyl transferase/5-fluorocytosine (CDU/5-FC) non-viral suicide system on eight established canine melanoma cell lines. Albeit with different degree of sensitivity 5 days after lip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9d25785b1236336fbac454ca04fcbd
https://pubmed.ncbi.nlm.nih.gov/34724324

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Proliferation index and pseudoprogression as predictors of the therapeutic efficacy of suicide gene therapy for canine melanoma

Autor: Liliana M.E. Finocchiaro, Gerardo C. Glikin, Chiara Fondello, Lucrecia Agnetti

In our veterinary clinical trials, the combination of systemic immunotherapy with local HSVtk/GCV suicide gene (SG) treatment induced tumor pseudo-progression as part of a strong local anti-tumor response. This phenomenon could be due to tumor inflam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22dadd0b56f49a25a0d6a40e8b0a33e8
https://journals.lww.com/melanomaresearch/Citation/2020/04000/Proliferation_index_and_pseudoprogression_as.2.aspx

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Combination of suicide and cytokine gene therapies as surgery adjuvant for canine mammary carcinoma

Autor: M Florencia Arbe, Lucrecia Agnetti, Gerardo Claudio Glikin, Liliana M.E. Finocchiaro, Agustina I M Spector

Publikováno v: Veterinary Sciences
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Veterinary Sciences, Vol 5, Iss 3, p 70 (2018)
Volume 5
Issue 3

The incidence of canine mammary carcinoma varies with age, breed, and spay status, being among the main tumors appearing in intact female dogs. Thirty-six canine mammary carcinoma patients received injections of canine interferon-&beta
(cIFN-&be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba5cdde598d5b4d4197995cee8cb030
http://www.mdpi.com/2306-7381/5/3/70

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Interferon-β gene transfer induces a strong cytotoxic bystander effect on melanoma cells

Autor: Liliana M.E. Finocchiaro, María L. Gil-Cardeza, Úrsula A. Rossi, Marcela Solange Villaverde, Gerardo Claudio Glikin

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

A local gene therapy scheme for the delivery of type I interferons could be an alternative for the treatment of melanoma. We evaluated the cytotoxic effects of interferon-β (IFNβ) gene lipofection on tumor cell lines derived from three human cutane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bd1e7086edfa6d9b434299fcd5eed8
https://doi.org/10.1016/j.biopha.2015.04.002

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The combination of bleomycin with suicide or interferon-B gene transfer is able to efficiently eliminate human melanoma tumor initiating cells

Autor: Marina Simian, Lucrecia Agnetti, Marcela Solange Villaverde, Chiara Fondello, Gerardo Claudio Glikin, Liliana M.E. Finocchiaro

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

We explored the potential of a chemogene therapy combination to eradicate melanoma tumor initiating cells, key producers of recurrence and metastatic spread. Three new human melanoma cell lines, two obtained from lymph nodes and one from spleen metas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ebc63eddc184efd66d8b20169bb91c
https://www.sciencedirect.com/science/article/abs/pii/S0753332216304012?via=ihub

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Cytokine-enhanced vaccine and interferon-β plus suicide gene as combined therapy for spontaneous canine sarcomas

Autor: María L. Gil-Cardeza, Liliana M.E. Finocchiaro, Marcela Solange Villaverde, Gerardo Claudio Glikin, María D. Riveros

Publikováno v: Research in Veterinary Science. 91:230-234

Eleven soft tissue- and five osteosarcoma canine patients were subjected to: (i) periodic subcutaneous injection of irradiated xenogeneic cells secreting hGM-CSF and hIL-2 mixed with allogeneic or autologous tumor homogenates; and (ii) injections of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47025218fff41afc139d4ef899df4d3f
https://doi.org/10.1016/j.rvsc.2010.12.012

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Interferon-β gene transfer inhibits melanoma cells adhesion and migration

Autor: Liliana M.E. Finocchiaro, Gerardo Claudio Glikin, Úrsula A. Rossi

Publikováno v: Cytokine. 89

We evaluated the effects of expression of interferon-β (IFNβ) after lipofection on melanoma cells adhesion and migration. Three canine mucosal (Ak, Br and Ol) and one human dermal (SB2) melanomas were assayed. By means of the wound healing assay, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5ceec001fbd0dd846f02d2a4242fc6
https://pubmed.ncbi.nlm.nih.gov/26597133

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Lipofection of early passages of cell cultures derived from murine adenocarcinomas: In vitro and ex vivo testing of the thymidine kinase/ganciclovir system

Autor: Liliana M.E. Finocchiaro, Gabriel L. Fiszman, Cecilia C. Casais, Gerardo Claudio Glikin, Viviana Florencia Bumaschny, Armando Luis Karara

Publikováno v: Cancer Gene Therapy. 9:96-99

Early passages of cultured cells derived from four spontaneous Balb/c murine adenocarcinomas were used to explore the feasibility of a nonviral HSVtk-based suicide gene therapy system. After lipofection with pCMVtk, the transiently HSVtk expressing P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449bd63658c201e2545a4f557b28fe54
https://doi.org/10.1038/sj.cgt.7700417

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Recent clinical trials of cancer immunogene therapy in companion animals

Autor: Liliana M.E. Finocchiaro, Gerardo Claudio Glikin

Publikováno v: World Journal of Experimental Medicine

This mini-review presents the results of veterinary clinical trials on immunogene therapy published from 2014 to 2016. A variety of tumors, among them melanoma (canine and equine), mastocytoma (canine), mammary adenocarcinoma (canine) and fibrosarcom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c449f1dd78ccb2e4e3eb68c9a738c4
https://doi.org/10.5493/wjem.v7.i2.42

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