Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Liliana Håversen"'
Autor:
Umberto Maria Battisti, Leticia Monjas, Fady Akladios, Josipa Matic, Eric Andresen, Carolin H. Nagel, Malin Hagkvist, Liliana Håversen, Woonghee Kim, Mathias Uhlen, Jan Borén, Adil Mardinoğlu, Morten Grøtli
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 668 (2023)
The inhibition of liver pyruvate kinase could be beneficial to halt or reverse non-alcoholic fatty liver disease (NAFLD), a progressive accumulation of fat in the liver that can lead eventually to cirrhosis. Recently, urolithin C has been reported as
Externí odkaz:
https://doaj.org/article/030b7f82a2c046bcb5af2aeb60b25820
Autor:
Sashidar Bandaru, Chandu Ala, Matias Ekstrand, Murali K Akula, Matteo Pedrelli, Xi Liu, Göran Bergström, Liliana Håversen, Jan Borén, Martin O Bergo, Levent M Akyürek
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239284 (2020)
The Rho GTPase RAC1 is an important regulator of cytoskeletal dynamics, but the role of macrophage-specific RAC1 has not been explored during atherogenesis. We analyzed RAC1 expression in human carotid atherosclerotic plaques using immunofluorescence
Externí odkaz:
https://doaj.org/article/93032c03f95f4957805f132fd801d33f
Autor:
Lu Li, Marcus Ståhlman, Mikael Rutberg, Liliana Håversen, Per Fogelstrand, Linda Andersson, Malin Levin, Jan Borén
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60118 (2013)
The small GTPase ADP ribosylation factor 6 (ARF6) mediates endocytosis and has in addition been shown to regulate neuron differentiation. Here we investigated whether ARF6 promotes differentiation of Neuro-2a neuronal cells by modifying the cellular
Externí odkaz:
https://doaj.org/article/6a36334d113a42ddad15077f1472fce8
Autor:
Lu Li, Bo Liu, Liliana Håversen, Emma Lu, Lisa U Magnusson, Marcus Ståhlman, Jan Borén, Göran Bergström, Malin C Levin, Lillemor Mattsson Hultén
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42360 (2012)
Atherosclerotic lesions are characterized by lipid-loaded macrophages (foam cells) and hypoxic regions. Although it is well established that foam cells are produced by uptake of cholesterol from oxidized LDL, we previously showed that hypoxia also pr
Externí odkaz:
https://doaj.org/article/243f32593c484812a021a69fbcbed616
Autor:
Umberto Maria Battisti, Chunxia Gao, Oscar Nilsson, Fady Akladios, Aleksei Lulla, Agnieszka Bogucka, Amalyn Nain‐Perez, Liliana Håversen, Woonghee Kim, Jan Boren, Marko Hyvönen, Mathias Uhlen, Adil Mardinoglu, Morten Grøtli
Publikováno v:
ChemBioChem. 24
Autor:
Lars Glise, Mikael Rutberg, Liliana Håversen, Malin C. Levin, Max Levin, Anders Jeppsson, Jan Borén, Per Fogelstrand
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 42(8)
Background: The initiating step in atherogenesis is the electrostatic binding of LDL (low-density lipoprotein) to proteoglycan glycosaminoglycans in the arterial intima. However, although proteoglycans are widespread throughout the intima of most cor
Autor:
Amalyn Nain-Perez, Anders Foller Füchtbauer, Liliana Håversen, Aleksei Lulla, Chunxia Gao, Josipa Matic, Leticia Monjas, Alexandra Rodríguez, Paul Brear, Woonghee Kim, Marko Hyvönen, Jan Borén, Adil Mardinoglu, Mathias Uhlen, Morten Grøtli
Publikováno v:
Nain-Perez, A, Foller Füchtbauer, A, Håversen, L, Lulla, A, Gao, C, Matic, J, Monjas, L, Rodríguez, A, Brear, P, Kim, W, Hyvönen, M, Borén, J, Mardinoglu, A, Uhlen, M & Grøtli, M 2022, ' Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase ', EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 234, 114270 . https://doi.org/10.1016/j.ejmech.2022.114270
Liver pyruvate kinase (PKL) is a major regulator of metabolic flux and ATP production during liver cell glycolysis and is considered a potential drug target for the treatment of non-alcoholic fatty liver disease (NAFLD). In this study, we report the
Publikováno v:
Chemical communications (Cambridge, England). 57(78)
A photoswitchable DFG-out kinase inhibitor has been developed. The activity of the inhibitor can efficiently be regulated by light in both enzymatic and living cell assays.
Autor:
Yongjin Xu, Chunxia Gao, Måns Andreasson, Liliana Håversen, Marta P. Carrasco, Cassandra Fleming, Thomas Lundbäck, Joakim Andréasson, Morten Grøtli
Publikováno v:
European Journal of Medicinal Chemistry. 234:114226
REarranged during Transfection (RET) is a transmembrane receptor tyrosine kinase that is required for development of multiple human tissues, but which is also an important contributor to human cancers. RET activation through rearrangement or point mu
Autor:
Murali K. Akula, Chandu Ala, Matias Ekstrand, Levent M. Akyürek, Göran Bergström, Xi Liu, Liliana Håversen, Matteo Pedrelli, Jan Borén, Sashidar Bandaru, Martin O. Bergo
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239284 (2020)
PLoS ONE
PLoS ONE
The Rho GTPase RAC1 is an important regulator of cytoskeletal dynamics, but the role of macrophage-specific RAC1 has not been explored during atherogenesis. We analyzed RAC1 expression in human carotid atherosclerotic plaques using immunofluorescence