Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Liliana B. Menalled"'
Autor:
Shalini Padmanabhan, Nicole K. Polinski, Liliana B. Menalled, Marco A.S. Baptista, Brian K. Fiske
Publikováno v:
Biomolecules, Vol 9, Iss 8, p 296 (2019)
The role of mitochondria in Parkinson’s disease (PD) has been investigated since the 1980s and is gaining attention with recent advances in PD genetics research. Mutations in PRKN and PTEN-Induced Putative Kinase 1 (PINK1) are well-established caus
Externí odkaz:
https://doaj.org/article/6deb061eadfa41afb8aa5886ea33041e
Autor:
Liliana B Menalled, Monica Patry, Natalie Ragland, Phillip A S Lowden, Jennifer Goodman, Jennie Minnich, Benjamin Zahasky, Larry Park, Janet Leeds, David Howland, Ethan Signer, Allan J Tobin, Daniela Brunner
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9793 (2010)
Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington's disease have produced conflicting results regarding their efficacy in behavioral tests. Using our recently published best practices for husbandry and test
Externí odkaz:
https://doaj.org/article/4fa4ff5e21dd404d8e4ec783503ea5d3
Autor:
Igor Filipov, Vanessa C. Wheeler, Matthew J. Mazzella, Liliana B. Menalled, Melinda C Ruiz, Ana Sanchez, Sylvie Ramboz, Brenda Lager, Marcy E. MacDonald, Ian Russell, Kimberly Cox, Miguel A. Gomez, Afshin Ghavami, Vadim Alexandrov, Seung Kwak, Dani Brunner, Justin Torello, Jeff Aaronson, Mei Kwan, Andrea E. Kudwa, James F. Gusella, Judy Watson-Johnson, Jim Rosinski, David Howland, Emily Sabath
Publikováno v:
Nature Biotechnology. 34:838-844
Rapid technological advances for the frequent monitoring of health parameters have raised the intriguing possibility that an individual's genotype could be predicted from phenotypic data alone. Here we used a machine learning approach to analyze the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de02ee20c5bcd7e158385f5185a6ccd
https://doi.org/10.1038/nbt.3587
https://doi.org/10.1038/nbt.3587
Autor:
Liliana B. Menalled, Daniela Brunner
Publikováno v:
Movement Disorders. 29:1375-1390
Mouse models of Huntington's disease (HD) recapitulate many aspects of the human disease. These genetically modified mice are powerful tools that are used not only to examine the pathogenesis of the disease, but also to assess the efficacy of potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5521e5445e2c98ba4d016d6e2a1888ae
https://doi.org/10.1002/mds.26006
https://doi.org/10.1002/mds.26006
Autor:
Dani Brunner, William Alosio, Kristi McConnell, Stephen Oakeshott, Liliana B. Menalled, Neil E. Paterson, Andrew M. Farrar, Sylvie Ramboz, Larry Park, Carol Murphy, David Howland, Dansha He
Publikováno v:
Journal of Huntington's Disease. 3:145-158
Background: Huntington’s disease (HD) is characterized not only by severe motor deficits but also by early cognitive dysfunction that significantly increases the burden of the disease for patients and caregivers. Considerable efforts have concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1d626c488431ca9b77004a69900952
https://doi.org/10.3233/jhd-130061
https://doi.org/10.3233/jhd-130061
Autor:
Paula Wasserman, Liliana B. Menalled, Nicole M. Lewandowski, Jean Paul G. Vonsattel, Jordan Muraskin, Herman Moreno, Usman A. Khan, Scott A. Small, Erica Y. Griffith, Sergio Angulo, Karen Marder, Adam M. Brickman, Yvette Bordelon
Publikováno v:
Neurobiology of Disease, Vol 52, Iss, Pp 84-93 (2013)
Although the huntingtin gene is expressed in brain throughout life, phenotypically Huntington's disease (HD) begins only in midlife to affect specific brain regions. Here, to investigate regional vulnerability in the disease, we used functional magne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4168530afe5e64e970e84d9df6441b
http://www.sciencedirect.com/science/article/pii/S0969996112003774
http://www.sciencedirect.com/science/article/pii/S0969996112003774
Autor:
Susanna Popp, Jorge Rodríguez, Diana Dow-Edwards, Liliana B. Menalled, Scott A Small, Dimitre Stefanov, Efrain Cepeda-Prado, Herman Moreno, Usman A. Khan
Publikováno v:
The Journal of Neuroscience. 32:6456-6467
A hallmark feature of Huntington's disease pathology is the atrophy of brain regions including, but not limited to, the striatum. Though MRI studies have identified structural CNS changes in several Huntington's disease (HD) mouse models, the functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9cc38983659ee1056d2765d8210cc5d
https://doi.org/10.1523/jneurosci.0388-12.2012
https://doi.org/10.1523/jneurosci.0388-12.2012
Autor:
Mayte Suárez-Fariñas, Liliana B. Menalled, Christina Leahy, Larry Park, Allan J. Tobin, Ethan Signer, Vanessa C. Wheeler, Monica Patry, Daniela Brunner, Marcy E. MacDonald, Janet M. Leeds, A. Jennifer Morton, X. William Yang, David Howland, Bassem F. El-Khodor, GP Bates, Benjamin Zahasky, Samantha J. Orenstein
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 319-336 (2009)
Huntington's disease (HD) is one of the few neurodegenerative diseases with a known genetic cause, knowledge that has enabled the creation of animal models using genetic manipulations that aim to recapitulate HD pathology. The study of behavioral and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557ce41620d6b4eb0ad112bf58a91534
https://doi.org/10.1016/j.nbd.2009.05.007
https://doi.org/10.1016/j.nbd.2009.05.007
Autor:
Liliana B. Menalled
Publikováno v:
NeuroRX. 2:465-470
Summary: Huntington's disease is an autosomal dominant neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for this fatal disease is an abnormally expanded and unstable CAG repea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb8f89e2c2b5fb1e3fba1868aead9cc
https://doi.org/10.1602/neurorx.2.3.465
https://doi.org/10.1602/neurorx.2.3.465
Autor:
Shane A. Worthge, Adeela Syed, Letizia Magnoni, Michela Camarri, Liliana B. Menalled, J. Lawrence Marsh, Andrea Caricasole, Marco Gianfriddo, Enrica Diodato, Tamas Lukacsovich, Ruth Luthi-Carter, Ozgun Gokce, Judy Purcell, Marianne R. Smith, Luisa Massai, Sylvie Ramboz, Stephen R. Wei, Davide Franceschini, Russell J. Thomas, Giuseppe Pollio, G Westerberg, Bernard Landwehrmeyer, Carla Scali, Brett A. Barbaro, Carol Murphy, Sarah J. Tabrizi
Publikováno v:
Human molecular genetics, vol 23, iss 11
Smith, MR; Syed, A; Lukacsovich, T; Purcell, J; Barbaro, BA; Worthge, SA; et al.(2014). A potent and selective sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of huntington's disease. Human Molecular Genetics, 23(11), 2995-3007. doi: 10.1093/hmg/ddu010. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/91m8n212
Smith, MR; Syed, A; Lukacsovich, T; Purcell, J; Barbaro, BA; Worthge, SA; et al.(2014). A potent and selective sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of huntington's disease. Human Molecular Genetics, 23(11), 2995-3007. doi: 10.1093/hmg/ddu010. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/91m8n212
Protein acetylation, which is central to transcriptional control as well as other cellular processes, is disrupted in Huntington's disease (HD). Treatments that restore global acetylation levels, such as inhibiting histone deacetylases (HDACs), are e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a945f412d35a8fd0b971b3108edc54b4
https://escholarship.org/uc/item/91m8n212
https://escholarship.org/uc/item/91m8n212
