Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Liliana B Menalled"'
Autor:
Liliana B Menalled, Andrea E Kudwa, Steve Oakeshott, Andrew Farrar, Neil Paterson, Igor Filippov, Sam Miller, Mei Kwan, Michael Olsen, Jose Beltran, Justin Torello, Jon Fitzpatrick, Richard Mushlin, Kimberly Cox, Kristi McConnell, Matthew Mazzella, Dansha He, Georgina F Osborne, Rand Al-Nackkash, Gill P Bates, Pasi Tuunanen, Kimmo Lehtimaki, Dani Brunner, Afshin Ghavami, Sylvie Ramboz, Larry Park, Douglas Macdonald, Ignacio Munoz-Sanjuan, David Howland
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99520 (2014)
Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by expansion of CAG repeats in the huntingtin gene. Tissue transglutaminase 2 (TG2), a multi-functional enzyme, was found to be increased both in HD pat
Externí odkaz:
https://doaj.org/article/32ac64f0a9ee4c26afbcfdfbe927af3c
Autor:
Liliana B Menalled, Andrea E Kudwa, Sam Miller, Jon Fitzpatrick, Judy Watson-Johnson, Nicole Keating, Melinda Ruiz, Richard Mushlin, William Alosio, Kristi McConnell, David Connor, Carol Murphy, Steve Oakeshott, Mei Kwan, Jose Beltran, Afshin Ghavami, Dani Brunner, Larry C Park, Sylvie Ramboz, David Howland
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e49838 (2012)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive and psychiatric manifestations. Since the mutation responsible for the disease was identified as an unstable expansion of CAG repeats in t
Externí odkaz:
https://doaj.org/article/7b9395c26cd34e0482a329a3cc5cbeb5
Autor:
Liliana B Menalled, Monica Patry, Natalie Ragland, Phillip A S Lowden, Jennifer Goodman, Jennie Minnich, Benjamin Zahasky, Larry Park, Janet Leeds, David Howland, Ethan Signer, Allan J Tobin, Daniela Brunner
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9793 (2010)
Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington's disease have produced conflicting results regarding their efficacy in behavioral tests. Using our recently published best practices for husbandry and test
Externí odkaz:
https://doaj.org/article/4fa4ff5e21dd404d8e4ec783503ea5d3
Autor:
Igor Filipov, Vanessa C. Wheeler, Matthew J. Mazzella, Liliana B. Menalled, Melinda C Ruiz, Ana Sanchez, Sylvie Ramboz, Brenda Lager, Marcy E. MacDonald, Ian Russell, Kimberly Cox, Miguel A. Gomez, Afshin Ghavami, Vadim Alexandrov, Seung Kwak, Dani Brunner, Justin Torello, Jeff Aaronson, Mei Kwan, Andrea E. Kudwa, James F. Gusella, Judy Watson-Johnson, Jim Rosinski, David Howland, Emily Sabath
Publikováno v:
Nature Biotechnology. 34:838-844
Rapid technological advances for the frequent monitoring of health parameters have raised the intriguing possibility that an individual's genotype could be predicted from phenotypic data alone. Here we used a machine learning approach to analyze the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de02ee20c5bcd7e158385f5185a6ccd
https://doi.org/10.1038/nbt.3587
https://doi.org/10.1038/nbt.3587
Autor:
Liliana B. Menalled, Daniela Brunner
Publikováno v:
Movement Disorders. 29:1375-1390
Mouse models of Huntington's disease (HD) recapitulate many aspects of the human disease. These genetically modified mice are powerful tools that are used not only to examine the pathogenesis of the disease, but also to assess the efficacy of potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5521e5445e2c98ba4d016d6e2a1888ae
https://doi.org/10.1002/mds.26006
https://doi.org/10.1002/mds.26006
Autor:
Dani Brunner, William Alosio, Kristi McConnell, Stephen Oakeshott, Liliana B. Menalled, Neil E. Paterson, Andrew M. Farrar, Sylvie Ramboz, Larry Park, Carol Murphy, David Howland, Dansha He
Publikováno v:
Journal of Huntington's Disease. 3:145-158
Background: Huntington’s disease (HD) is characterized not only by severe motor deficits but also by early cognitive dysfunction that significantly increases the burden of the disease for patients and caregivers. Considerable efforts have concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1d626c488431ca9b77004a69900952
https://doi.org/10.3233/jhd-130061
https://doi.org/10.3233/jhd-130061
Autor:
Paula Wasserman, Liliana B. Menalled, Nicole M. Lewandowski, Jean Paul G. Vonsattel, Jordan Muraskin, Herman Moreno, Usman A. Khan, Scott A. Small, Erica Y. Griffith, Sergio Angulo, Karen Marder, Adam M. Brickman, Yvette Bordelon
Publikováno v:
Neurobiology of Disease, Vol 52, Iss, Pp 84-93 (2013)
Although the huntingtin gene is expressed in brain throughout life, phenotypically Huntington's disease (HD) begins only in midlife to affect specific brain regions. Here, to investigate regional vulnerability in the disease, we used functional magne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4168530afe5e64e970e84d9df6441b
http://www.sciencedirect.com/science/article/pii/S0969996112003774
http://www.sciencedirect.com/science/article/pii/S0969996112003774
Autor:
Susanna Popp, Jorge Rodríguez, Diana Dow-Edwards, Liliana B. Menalled, Scott A Small, Dimitre Stefanov, Efrain Cepeda-Prado, Herman Moreno, Usman A. Khan
Publikováno v:
The Journal of Neuroscience. 32:6456-6467
A hallmark feature of Huntington's disease pathology is the atrophy of brain regions including, but not limited to, the striatum. Though MRI studies have identified structural CNS changes in several Huntington's disease (HD) mouse models, the functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9cc38983659ee1056d2765d8210cc5d
https://doi.org/10.1523/jneurosci.0388-12.2012
https://doi.org/10.1523/jneurosci.0388-12.2012
Autor:
Mayte Suárez-Fariñas, Liliana B. Menalled, Christina Leahy, Larry Park, Allan J. Tobin, Ethan Signer, Vanessa C. Wheeler, Monica Patry, Daniela Brunner, Marcy E. MacDonald, Janet M. Leeds, A. Jennifer Morton, X. William Yang, David Howland, Bassem F. El-Khodor, GP Bates, Benjamin Zahasky, Samantha J. Orenstein
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 319-336 (2009)
Huntington's disease (HD) is one of the few neurodegenerative diseases with a known genetic cause, knowledge that has enabled the creation of animal models using genetic manipulations that aim to recapitulate HD pathology. The study of behavioral and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557ce41620d6b4eb0ad112bf58a91534
https://doi.org/10.1016/j.nbd.2009.05.007
https://doi.org/10.1016/j.nbd.2009.05.007
Autor:
Liliana B. Menalled
Publikováno v:
NeuroRX. 2:465-470
Summary: Huntington's disease is an autosomal dominant neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for this fatal disease is an abnormally expanded and unstable CAG repea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb8f89e2c2b5fb1e3fba1868aead9cc
https://doi.org/10.1602/neurorx.2.3.465
https://doi.org/10.1602/neurorx.2.3.465