Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Liliana, Minichiello"'
Autor:
Wenling Li, Katherine Lipsius, Nathan G. Burns, Ryo Sato, Azaan Rehman, Hui Xue, Christian Combs, Liliana Minichiello, Harshi Gangrade, Emmanouil Tampakakis, Yoh-suke Mukouyama
Publikováno v:
Biology Open, Vol 13, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/2e7b3bbb43714a049d7e1a87e2289052
Publikováno v:
Biology, Vol 13, Iss 8, p 637 (2024)
In ataxia disorders, motor incoordination (ataxia) is primarily linked to the dysfunction and degeneration of cerebellar Purkinje cells (PCs). In spinocerebellar ataxia 6 (SCA6), for example, decreased BDNF–TrkB signalling appears to contribute to
Externí odkaz:
https://doaj.org/article/42de4196cffd4bd5a7db4d9add1f5bf1
Autor:
Seungyong Lee, Charles Hwang, Simone Marini, Robert J. Tower, Qizhi Qin, Stefano Negri, Chase A. Pagani, Yuxiao Sun, David M. Stepien, Michael Sorkin, Carrie A. Kubiak, Noelle D. Visser, Carolyn A. Meyers, Yiyun Wang, Husain A. Rasheed, Jiajia Xu, Sarah Miller, Amanda K. Huber, Liliana Minichiello, Paul S. Cederna, Stephen W. P. Kemp, Thomas L. Clemens, Aaron W. James, Benjamin Levi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and
Externí odkaz:
https://doaj.org/article/8294374ecf224a3ea40a708dc54a22e2
Autor:
William W. Greenwald, Joshua Chiou, Jian Yan, Yunjiang Qiu, Ning Dai, Allen Wang, Naoki Nariai, Anthony Aylward, Jee Yun Han, Nikita Kadakia, Laura Regue, Mei-Lin Okino, Frauke Drees, Dana Kramer, Nicholas Vinckier, Liliana Minichiello, David Gorkin, Joseph Avruch, Kelly A. Frazer, Maike Sander, Bing Ren, Kyle J. Gaulton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Risk loci for type 2 diabetes (T2D) reside in pancreatic islet enhancers. Here, the authors generate high-resolution maps of islet chromatin conformation using Hi-C which they combine with ATAC-seq and ChIP-seq data to annotate candidate target genes
Externí odkaz:
https://doaj.org/article/2308d1b8b59042bb8921a23b1acf35fe
Autor:
Jacek Szymanski, Liliana Minichiello
Publikováno v:
Brain Sciences, Vol 12, Iss 4, p 502 (2022)
The time-sensitive GABA shift from excitatory to inhibitory is critical in early neural circuits development and depends upon developmentally regulated expression of cation-chloride cotransporters NKCC1 and KCC2. NKCC1, encoded by the SLC12A2 gene, r
Externí odkaz:
https://doaj.org/article/29e5efb289294c838b7eaa8cb3dfa679
Autor:
Carolyn A. Meyers, Seungyong Lee, Takashi Sono, Jiajia Xu, Stefano Negri, Ye Tian, Yiyun Wang, Zhu Li, Sarah Miller, Leslie Chang, Yongxing Gao, Liliana Minichiello, Thomas L. Clemens, Aaron W. James
Publikováno v:
Cell Reports, Vol 31, Iss 8, Pp - (2020)
Summary: The flat bones of the skull are densely innervated during development, but little is known regarding their role during repair. We describe a neurotrophic mechanism that directs sensory nerve transit in the mouse calvaria. Patent cranial sutu
Externí odkaz:
https://doaj.org/article/c9fa6b45d5784790aa223ef600a43cc7
Autor:
Sylvia Badurek, Marilena Griguoli, Aman Asif-Malik, Barbara Zonta, Fei Guo, Silvia Middei, Laura Lagostena, Maria Teresa Jurado-Parras, Thomas H. Gillingwater, Agnès Gruart, José María Delgado-García, Enrico Cherubini, Liliana Minichiello
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Early in brain development, impaired neuronal signaling during time-sensitive windows triggers the onset of neurodevelopmental disorders. GABA, through its depolarizing and excitatory actions, drives early developmental events including neur
Externí odkaz:
https://doaj.org/article/2880f8a3122b4856a0cc9a58b1dfea98
Autor:
Ryan E. Tomlinson, Zhi Li, Qian Zhang, Brian C. Goh, Zhu Li, Daniel L.J. Thorek, Labchan Rajbhandari, Thomas M. Brushart, Liliana Minichiello, Fengquan Zhou, Arun Venkatesan, Thomas L. Clemens
Publikováno v:
Cell Reports, Vol 16, Iss 10, Pp 2723-2735 (2016)
Developing tissues dictate the amount and type of innervation they require by secreting neurotrophins, which promote neuronal survival by activating distinct tyrosine kinase receptors. Here, we show that nerve growth factor (NGF) signaling through ne
Externí odkaz:
https://doaj.org/article/98ef489b29e74253b6a9a78c33b2027d
Autor:
Mohd Yaseen Malik, Fei Guo, Aman Asif-Malik, Vasileios Eftychidis, Nikolaos Barkas, Elena Eliseeva, Kerstin Timm, David Bergin, Barbara Zonta, Peter Magill, Claus Nerlov, Liliana Minichiello
Identification of initial triggering events in neurodegenerative disorders is critical to the development of preventive therapies. In Huntington’s disease (HD), hyperdopaminergia triggered by dysfunction of inhibitory indirect pathway spiny project
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fc2c89cf06a4ff515b503c72195aca1
https://doi.org/10.21203/rs.3.rs-2456799/v1
https://doi.org/10.21203/rs.3.rs-2456799/v1
Publikováno v:
eLife, Vol 6 (2017)
The gene encoding the Insulin-like Growth Factor 2 mRNA binding protein 2/IMP2 is amplified and overexpressed in many human cancers, accompanied by a poorer prognosis. Mice lacking IMP2 exhibit a longer lifespan and a reduced tumor burden at old age.
Externí odkaz:
https://doaj.org/article/f2b71f8d4f9d43a1af9220ea97af6c8c