Oral Tolerance Induction by Bothrops jararaca Venom in a Murine Model and Cross-Reactivity with Toxins of Other Snake Venoms

Autor: Lilian Rumi Tsuruta, Ana Maria Moro, Denise V. Tambourgi, Osvaldo Augusto Sant’Anna

Publikováno v: Toxins, Vol 13, Iss 12, p 865 (2021)

Oral tolerance is defined as a specific suppression of cellular and humoral immune responses to a particular antigen through prior oral administration of an antigen. It has unique immunological importance since it is a natural and continuous event dr

Externí odkaz: https://doaj.org/article/183f9eb675394524850c60f6980dbb70

Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer.

Autor: Mariana Lopes dos Santos, Fernanda Perez Yeda, Lilian Rumi Tsuruta, Bruno Brasil Horta, Alécio A Pimenta, Theri Leica Degaki, Ibere C Soares, Maria Carolina Tuma, Oswaldo Keith Okamoto, Venancio A F Alves, Lloyd J Old, Gerd Ritter, Ana Maria Moro

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e70332 (2013)

NaPi2b, a sodium-dependent phosphate transporter, is highly expressed in ovarian carcinomas and is recognized by the murine monoclonal antibody MX35. The antibody had shown excellent targeting to ovarian cancer in several early phase clinical trials

Externí odkaz: https://doaj.org/article/d963669f4fe0458ea7459834bd3e8964

Advances and challenges in therapeutic monoclonal antibodies drug development

Autor: Ana Maria Moro, Tania Maria Manieri, Lilian Rumi Tsuruta, Mariana Lopes dos Santos, Wagner Quintilio

Publikováno v: Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. Especial (2018); e01007
Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. Especial (2018); e01007
Brazilian Journal of Pharmaceutical Sciences; v. 54 n. Especial (2018); e01007
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Pharmaceutical Sciences, Vol 54, Iss spe (2018)

The use of serum containing polyclonal antibodies from animals immunized with toxins marked the beginning of the application of antibody-based therapy in late nineteenth century. Advances in basic research led to the development of the hybridoma tech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d470abd70f1b9cd28debf6c510d486
https://www.revistas.usp.br/bjps/article/view/153906

Anti-Digoxin Fab Variants Generated by Phage Display

Autor: Lilian Rumi Tsuruta, Jorge Kalil, Ana Maria Moro, Mariana Costa Braga Schmidt, Viviane Midori Murata

Publikováno v: Molecular Biotechnology. 54:269-277

Digoxin is a pharmaceutical used in the control of cardiac dysfunction. Its therapeutic window is narrow, with effect dosage very close to the toxic dosage. To counteract the toxic effect, polyclonal Fab fragments are commercially available. Our stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dedb89d2d8cd466523fe051ca377348
https://doi.org/10.1007/s12033-012-9564-1

Design, Production, and Characterization of Recombinant Neocarzinostatin Apoprotein in Escherichia coli

Autor: Kunihiko Itoh, Masayuki Inoue, Yoshihisa Tomioka, Yoko Nagumo, Toshio Suzuki, Toshiki Matsumoto, Yoshinori Kato, Shunji Ishiwata, Masahiro Hirama, Michinao Mizugaki, Seishiro Nozaki, Takanori Hishinuma, Lilian Rumi Tsuruta, Katsuhiro Hayashi

Publikováno v: Journal of Biochemistry. 131:729-738

Neocarzinostatin (NCS) is the first discovered anti-tumor antibiotic having an enediyne-containing chromophore and an apoprotein with a 1:1 complex. An artificial gene library for NCS apoprotein (apo-NCS) production in Escherichia coli was designed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea01e430ca69ed05812da4d08ac3ea9
https://doi.org/10.1093/oxfordjournals.jbchem.a003158