Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Lilian Phu"'
Autor:
Max Adrian, Martin Weber, Ming-Chi Tsai, Caspar Glock, Olga I. Kahn, Lilian Phu, Tommy K. Cheung, William J. Meilandt, Christopher M. Rose, Casper C. Hoogenraad
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Microglial reactivity is a pathological hallmark in many neurodegenerative diseases. During stimulation, microglia undergo complex morphological changes, including loss of their characteristic ramified morphology, which is routinely used to
Externí odkaz:
https://doaj.org/article/07f1bdd5b8fc4c30814079f35fbb9f55
Autor:
Christopher W. Davies, Simon E. Vidal, Lilian Phu, Jawahar Sudhamsu, Trent B. Hinkle, Scott Chan Rosenberg, Frances-Rose Schumacher, Yi Jimmy Zeng, Carsten Schwerdtfeger, Andrew S. Peterson, Jennie R. Lill, Christopher M. Rose, Andrey S. Shaw, Ingrid E. Wertz, Donald S. Kirkpatrick, James T. Koerber
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
UBE2W catalyzes the ubiquitination of protein N-termini but its substrate spectrum is largely unknown. Here, the authors discover mAbs selective for peptides derived from N-terminally ubiquitinated proteins, solve the structure of a peptide-bound mAb
Externí odkaz:
https://doaj.org/article/cbfb2674260f4b51a1c495c83e07dcb5
Autor:
Avinashnarayan Venkatanarayan, Jason Liang, Ivana Yen, Frances Shanahan, Benjamin Haley, Lilian Phu, Erik Verschueren, Trent B. Hinkle, David Kan, Ehud Segal, Jason E. Long, Tony Lima, Nicholas P.D. Liau, Jawahar Sudhamsu, Jason Li, Christiaan Klijn, Robert Piskol, Melissa R. Junttila, Andrey S. Shaw, Mark Merchant, Matthew T. Chang, Donald S. Kirkpatrick, Shiva Malek
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110351- (2022)
Summary: KRAS, which is mutated in ∼30% of all cancers, activates the RAF-MEK-ERK signaling cascade. CRAF is required for growth of KRAS mutant lung tumors, but the requirement for CRAF kinase activity is unknown. Here, we show that subsets of KRAS
Externí odkaz:
https://doaj.org/article/fa5d3d0fa6ab4799a1b8b428959ad8e4
Autor:
Arundhati Sengupta-Ghosh, Sara L. Dominguez, Luke Xie, Kai H. Barck, Zhiyu Jiang, Timothy Earr, Jose Imperio, Lilian Phu, Hanna G. Budayeva, Donald S. Kirkpatrick, Hao Cai, Jeffrey Eastham-Anderson, Hai Ngu, Oded Foreman, Maj Hedehus, Michael Reichelt, Isidro Hotzel, Yonglei Shang, Richard A.D. Carano, Gai Ayalon, Amy Easton
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 340-352 (2019)
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure. As motor neuron death occurs late in the disease, therapeutics that prev
Externí odkaz:
https://doaj.org/article/cd3e464eb6fd4c10b7ea4c66731e7e28
Autor:
Arundhati Sengupta-Ghosh, Sara L. Dominguez, Luke Xie, Kai H. Barck, Zhiyu Jiang, Timothy Earr, Jose Imperio, Lilian Phu, Hanna G. Budayeva, Donald S. Kirkpatrick, Hao Cai, Dongping He, Jeffrey Eastham-Anderson, Hai Ngu, Oded Foreman, Maj Hedehus, Michael Reichelt, Isidro Hotzel, Yonglei Shang, Richard A.D. Carano, Gai Ayalon, Amy Easton
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Externí odkaz:
https://doaj.org/article/58fe892cb1214380bab2aa7374ed2e49
Autor:
Marinella G Callow, Hoanh Tran, Lilian Phu, Ted Lau, James Lee, Wendy N Sandoval, Peter S Liu, Sheila Bheddah, Janet Tao, Jennie R Lill, Jo-Anne Hongo, David Davis, Donald S Kirkpatrick, Paul Polakis, Mike Costa
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22595 (2011)
Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which is dependent on Axin scaffolding of a complex that phosphorylates β-catenin to target it for ubiquitylation and proteasomal degradation. This function of
Externí odkaz:
https://doaj.org/article/dd787cda777a424996475d2d515fd403
Autor:
Lori S. Friedman, Anwesha Dey, Donald S. Kirkpatrick, Steven T. Staben, Shiva Malek, Alan G. Olivero, Timothy P. Heffron, Laurent Salphati, Gail D. Lewis Phillips, Emile G. Plise, Jonathan Cheong, Jeffrey J. Wallin, Jane Guan, Nicholas Endres, Stephen Schmidt, Eric Stawiski, William F. Forrest, Lilian Phu, Rebecca Hong, Michelle A. Nannini, Deepak Sampath, Mark Merchant, Jason Oeh, Marc Hafner, Emily J. Hanan, Kyle A. Edgar, Kyung W. Song
RTK activity plays a key role in regulating p110a degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3f61f91c6eba4539d57e9ffe438944
https://doi.org/10.1158/2159-8290.22540279
https://doi.org/10.1158/2159-8290.22540279
Autor:
Lori S. Friedman, Anwesha Dey, Donald S. Kirkpatrick, Steven T. Staben, Shiva Malek, Alan G. Olivero, Timothy P. Heffron, Laurent Salphati, Gail D. Lewis Phillips, Emile G. Plise, Jonathan Cheong, Jeffrey J. Wallin, Jane Guan, Nicholas Endres, Stephen Schmidt, Eric Stawiski, William F. Forrest, Lilian Phu, Rebecca Hong, Michelle A. Nannini, Deepak Sampath, Mark Merchant, Jason Oeh, Marc Hafner, Emily J. Hanan, Kyle A. Edgar, Kyung W. Song
PIK3CA is one of the most frequently mutated oncogenes; the p110a protein it encodes plays a central role in tumor cell proliferation. Small-molecule inhibitors targeting the PI3K p110a catalytic subunit have entered clinical trials, with early-phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd67c192262a4b6f3e1d058d9266830
https://doi.org/10.1158/2159-8290.c.6549343
https://doi.org/10.1158/2159-8290.c.6549343
Autor:
Devon Kohler, Tsung-Heng Tsai, Erik Verschueren, Ting Huang, Trent Hinkle, Lilian Phu, Meena Choi, Olga Vitek
Publikováno v:
Molecularcellular proteomics : MCP.
Liquid chromatography coupled with bottom up mass spectrometry (LC-MS/MS)-based proteomics is increasingly used to detect changes in post-translational modifications (PTMs) in samples from different conditions. Analysis of data from such experiments
Autor:
Scott C. Rosenberg, James T. Koerber, Christopher M. Rose, Donald S. Kirkpatrick, Simon E. Vidal, Andrey S. Shaw, Ingrid E. Wertz, Trent Hinkle, Lilian Phu, Frances-Rose Schumacher, Andrew S. Peterson, Yi Zeng, Carsten Schwerdtfeger, Jennie R. Lill, Jawahar Sudhamsu, Christopher W. Davies
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The ubiquitin conjugating enzyme UBE2W catalyzes non-canonical ubiquitination on the N-termini of proteins, although its substrate repertoire remains unclear. To identify endogenous N-terminally-ubiquitinated substrates, we discover four monoclonal a