Výsledky vyhledávání - "Lilian H.J. Richter"

In vitro toxicokinetics and analytical toxicology of three novel NBOMe derivatives: phase I and II metabolism, plasma protein binding, and detectability in standard urine screening approaches studied by means of hyphenated mass spectrometry

Autor: Lilian H.J. Richter, Markus R. Meyer, Lea Wagmann, Simon D. Brandt, Folker Westphal, Alexander Stratford, Veit Flockerzi, Julia Menges

Publikováno v: Forensic Toxicology. 38:141-159

Purpose Toxicokinetic studies are essential in clinical and forensic toxicology to understand drug-drug interactions, influence of individual polymorphisms, and elimination routes, as well as to evaluate targets for toxicological screening procedures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bb8166b7ae8921c92215a84012661e
https://doi.org/10.1007/s11419-019-00498-7

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Toxicokinetics and analytical toxicology of the abused opioid U-48800 - in vitro metabolism, metabolic stability, isozyme mapping, and plasma protein binding

Autor: Lea Wagmann, Markus R. Meyer, Tanja M. Gampfer, Lilian H.J. Richter, Jan Schäper

Due to the risk of new synthetic opioids (NSOs) for human health, the knowledge of their toxicokinetic characteristics is important for clinical and forensic toxicology. U-48800 is an NSO structurally non-related to classical opioids such as morphine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679c2282c65cb1c15314b6c02398e34d

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Different in vitro and in vivo tools for elucidating the human metabolism of alpha-cathinone-derived drugs of abuse

Autor: Sascha K. Manier, Markus R. Meyer, Lilian H.J. Richter, Hans H. Maurer, Jan Schäper

In vitro and in vivo experiments are widely used for studying the metabolism of new psychoactive substances (NPS). The availability of such data is required for toxicological risk assessments and development of urine screening approaches. This study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b35db59269891a90f681578cb53d33

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New psychoactive substances: Studies on the metabolism of XLR-11, AB-PINACA, FUB-PB-22, 4-methoxy-α-PVP, 25-I-NBOMe, and meclonazepam using human liver preparations in comparison to primary human hepatocytes, and human urine

Autor: Lilian H.J. Richter, Hans H. Maurer, Markus R. Meyer

Publikováno v: Toxicology Letters. 280:142-150

New psychoactive substances (NPS) are an increasing problem in clinical and forensic toxicology. The knowledge of their metabolism is important for toxicological risk assessment and for developing toxicological urine screenings. Considering the huge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5510471f3c42bccd928e3befc6adc5
https://doi.org/10.1016/j.toxlet.2017.07.901

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Pooled human liver preparations, HepaRG, or HepG2 cell lines for metabolism studies of new psychoactive substances? A study using MDMA, MDBD, butylone, MDPPP, MDPV, MDPB, 5-MAPB, and 5-API as examples

Autor: Veit Flockerzi, Markus R. Meyer, Hans H. Maurer, Lilian H.J. Richter

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 143:32-42

Metabolism studies play an important role in clinical and forensic toxicology. Because of potential species differences in metabolism, human samples are best suitable for elucidating metabolism. However, in the case of new psychoactive substances (NP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b56552afb79689b2b7b88ee72628f10
https://doi.org/10.1016/j.jpba.2017.05.028

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Phenethylamine-derived new psychoactive substances 2C-E-FLY, 2C-EF-FLY, and 2C-T-7-FLY: Investigations on their metabolic fate including isoenzyme activities and their toxicological detectability in urine screenings

Autor: Markus R. Meyer, Lea Wagmann, Lilian H.J. Richter, Simon D. Brandt, Alexander Stratford, Nora Hempel

Publikováno v: Drug testing and analysisREFERENCES. 11(10)

Psychoactive substances of the 2C-series are phenethylamine-based designer drugs that can induce psychostimulant and hallucinogenic effects. The so-called 2C-FLY series contains rigidified methoxy groups integrated in a 2,3,6,7-tetrahydrobenzo[1,2-b:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815a27741e8d0f9b50719ffeddb447fe
https://pubmed.ncbi.nlm.nih.gov/31299701

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Development and application of a LC-HRMS/MS method for analyzing antihypertensive drugs in oral fluid for monitoring drug adherence

Autor: Felix Mahfoud, Michael Böhm, Ingrid Kindermann, Markus R. Meyer, Cathy M. Jacobs, Lilian H.J. Richter

Publikováno v: Analytica chimica acta. 1070

Nonadherence to antihypertensive drugs therapy is known to be a serious issue in hypertension treatment. Liquid chromatography (LC) coupled to mass spectrometry (MS) was shown to allow the assessment of such nonadherence in blood and urine sample. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8282f68ddcc927205e353fefca5b8b
https://pubmed.ncbi.nlm.nih.gov/31103169

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Tools for studying the metabolism of new psychoactive substances for toxicological screening purposes - A comparative study using pooled human liver S9, HepaRG cells, and zebrafish larvae

Autor: Rolf Müller, Anastasia Andreas, Veit Flockerzi, Jennifer Herrmann, Lea Wagmann, Lilian H.J. Richter, Yu Mi Park, Markus R. Meyer

Publikováno v: Toxicology letters

New psychoactive substances (NPS) are an emerging topic amongst abused compounds. New varieties appear constantly on the market, without any knowledge about their toxicodynamic and/or -kinetic properties and knowledge of their metabolism is crucial f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686773e6cd118b1beaa22664a006107e
https://hdl.handle.net/10033/621710

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Metabolic fate of desomorphine elucidated using rat urine, pooled human liver preparations, and human hepatocyte cultures as well as its detectability using standard urine screening approaches

Autor: Lilian H.J. Richter, Hans H. Maurer, Y. Kaminski, Fozia Noor, Markus R. Meyer

Publikováno v: Analytical and Bioanalytical Chemistry. 408:6283-6294

Desomorphine is an opioid misused as "crocodile", a cheaper alternative to heroin. It is a crude synthesis product homemade from codeine with toxic byproducts. The aim of the present work was to investigate the metabolic fate of desomorphine in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af910a67a10d040fabee8ecde808a18
https://doi.org/10.1007/s00216-016-9740-4

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