Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lilian Fernandes Silva"'
Autor:
Sahereh Mirzaei, Holli A. DeVon, Rita M. Cantor, Arjen Cupido, Lilian Fernandes Silva, Markku Laakso, Aldons J. Lusis
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
BackgroundAn association between gut microbes and cardiovascular disease (CVD) has been established, but the underlying mechanisms remain largely unknown.MethodsWe conducted a secondary analysis of the cross-sectional data obtained from the Metabolic
Externí odkaz:
https://doaj.org/article/c6c6fd52b19148cb9bb877267853c124
Autor:
Sahereh Mirzaei, Holli A. DeVon, Rita M. Cantor, Arjen J. Cupido, Calvin Pan, Sung Min Ha, Lilian Fernandes Silva, James R. Hilser, Jaana Hartiala, Hooman Allayee, Federico E. Rey, Markku Laakso, Aldons J. Lusis
Publikováno v:
Metabolites, Vol 14, Iss 3, p 174 (2024)
The role of gut microbe-derived metabolites in the development of metabolic syndrome (MetS) remains unclear. This study aimed to evaluate the associations of gut microbe-derived metabolites and MetS traits in the cross-sectional Metabolic Syndrome In
Externí odkaz:
https://doaj.org/article/1237cc0e945a40e497d0690efed8b753
Autor:
Markku Laakso, Lilian Fernandes Silva
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Statins are widely used to prevent cardiovascular disease events. Cardiovascular diseases and type 2 diabetes are tightly connected since type 2 diabetes is a major risk factor for cardiovascular diseases. Additionally, cardiovascular diseases often
Externí odkaz:
https://doaj.org/article/a85dd0f8f2f14616b409beb5e67fc35f
Autor:
Xianyong Yin, Lap Sum Chan, Debraj Bose, Anne U. Jackson, Peter VandeHaar, Adam E. Locke, Christian Fuchsberger, Heather M. Stringham, Ryan Welch, Ketian Yu, Lilian Fernandes Silva, Susan K. Service, Daiwei Zhang, Emily C. Hector, Erica Young, Liron Ganel, Indraniel Das, Haley Abel, Michael R. Erdos, Lori L. Bonnycastle, Johanna Kuusisto, Nathan O. Stitziel, Ira M. Hall, Gregory R. Wagner, FinnGen, Jian Kang, Jean Morrison, Charles F. Burant, Francis S. Collins, Samuli Ripatti, Aarno Palotie, Nelson B. Freimer, Karen L. Mohlke, Laura J. Scott, Xiaoquan Wen, Eric B. Fauman, Markku Laakso, Michael Boehnke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The Finnish population is enriched for genetic variants which are rare in other populations. Here, the authors find new genetic loci associated with 1391 circulating metabolites in 6136 Finnish men, demonstrating that metabolite genetic associations
Externí odkaz:
https://doaj.org/article/2bfc641ed38244daa7d87b37ef3b16fc
Autor:
Lilian Fernandes Silva, Jagadish Vangipurapu, Anniina Oravilahti, Ville Männistö, Markku Laakso
Publikováno v:
Metabolites, Vol 13, Iss 2, p 267 (2023)
Both genetic and non-genetic factors are important in the pathophysiology of non-alcoholic fatty liver disease (NAFLD). The aim of our study was to identify novel metabolites and pathways associated with NAFLD by including both genetic and non-geneti
Externí odkaz:
https://doaj.org/article/6c29663d64fd4b85a8d17ad67a974c94
Autor:
Lilian Fernandes Silva, Rowmika Ravi, Jagadish Vangipurapu, Anniina Oravilahti, Markku Laakso
Publikováno v:
Metabolites, Vol 12, Iss 12, p 1159 (2022)
Organic-anion-transporting polypeptide 1B1 (OATP1B1), encoded by the solute carrier organic anion transporter family member 1B1 gene (SLCO1B1), is highly expressed in the liver and transports several endogenous metabolites into the liver, including s
Externí odkaz:
https://doaj.org/article/5e9ace0544674fe28c5ea62eea833826
Publikováno v:
Metabolites, Vol 12, Iss 8, p 753 (2022)
Statins inhibit the 3-hydroxy-3-methylglutaryl-CoA reductase enzyme and are the most widely used medication for hypercholesterolemia. Previous studies on the metabolite signature of simvastatin treatment have included only a small number of metabolit
Externí odkaz:
https://doaj.org/article/ff7e311a3b6d4d75abe1ab3ce46ae7cc
Autor:
Rowmika Ravi, Lilian Fernandes Silva, Jagadish Vangipurapu, Maleeha Maria, Joose Raivo, Seppo Helisalmi, Markku Laakso
Publikováno v:
Metabolites, Vol 12, Iss 5, p 437 (2022)
Hypertrophic (HCM) and dilated (DCM) cardiomyopathies are among the leading causes of sudden cardiac death. We identified 38 pathogenic or likely pathogenic variant carriers for HCM in three sarcomere genes (MYH7, MYBPC3, TPMI) among 9.928 participan
Externí odkaz:
https://doaj.org/article/2b89189764c84d4ba5739770ff64a84d
Autor:
Susanna Maria Kemppainen, Lilian Fernandes Silva, Maria Anneli Lankinen, Ursula Schwab, Markku Laakso
Publikováno v:
Metabolites, Vol 12, Iss 1, p 69 (2022)
Large population-based studies investigating the association of physical activity (PA) with the metabolite signature contribute significantly to the understanding of the effects of PA on metabolic pathways associated with the risk of type2 diabetes.
Externí odkaz:
https://doaj.org/article/ca8c9ad9a59142cca7497bdc0793d1d4
Publikováno v:
Metabolites, Vol 11, Iss 10, p 691 (2021)
The prevalence and the incidence of type 2 diabetes (T2D), representing >90% of all cases of diabetes, are increasing rapidly worldwide. Identification of individuals at high risk of developing diabetes is of great importance, as early interventions
Externí odkaz:
https://doaj.org/article/08669860429b4d64990b127edee862dd