Intracellular Peptides in Cell Biology and Pharmacology

Autor: Christiane B. de Araujo, Andrea S. Heimann, Ricardo A. Remer, Lilian C. Russo, Alison Colquhoun, Fábio L. Forti, Emer S. Ferro

Publikováno v: Biomolecules, Vol 9, Iss 4, p 150 (2019)

Intracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases generating a larger pool of peptides within cells. Thousands of intracel

Externí odkaz: https://doaj.org/article/d3ce3ad7d3864fa293cfb66a60311681

Nucleophosmin Protein Dephosphorylation by DUSP3 Is a Fine-Tuning Regulator of p53 Signaling to Maintain Genomic Stability

Autor: Fabio Luis Forti, Pault Yeison Minaya Ferruzo, Lilian C. Russo

Publikováno v: Frontiers in Cell and Developmental Biology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Cell and Developmental Biology, Vol 9 (2021)

The dual-specificity phosphatase 3 (DUSP3), an atypical protein tyrosine phosphatase (PTP), regulates cell cycle checkpoints and DNA repair pathways under conditions of genotoxic stress. DUSP3 interacts with the nucleophosmin protein (NPM) in the cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279cc7ca0f70e0f63e9da92483d3d780
https://doi.org/10.3389/fcell.2021.624933

Overactivated Cdc42 acts through Cdc42EP3/Borg2 and NCK to trigger DNA damage response signaling and sensitize cells to DNA-damaging agents

Autor: Luiz Eduardo da Silva, Lilian C. Russo, Fabio Luis Forti

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The small GTPase Cdc42, a member of the Rho family, regulates essential biological processes such as cytoskeleton remodeling, migration, vesicular trafficking and cell cycle. It was demonstrated that Cdc42 overactivation through different molecular s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0087cfe613db14faf6cdca1902721644
https://pubmed.ncbi.nlm.nih.gov/32739212

DUSP3 maintains genomic stability and cell proliferation by modulating NER pathway and cell cycle regulatory proteins

Autor: Fabio Luis Forti, Lilian C. Russo, Jessica Oliveira Farias

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cell Cycle

The DUSP3 phosphatase regulates cell cycle, proliferation, apoptosis and senescence of different cell types, lately shown as a mediator of DNA repair processes. This work evaluated the impact of DUSP3 loss of function (lof) on DNA repair-proficient f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b779a85f08a24cf8fab48bcd840e0502

Interferon-gamma activity is potentiated by an intracellular peptide derived from the human 19S ATPase regulatory subunit 4 of the proteasome

Autor: Jean Pierre Schatzmann Peron, Lilian C. Russo, Osvaldo A. Sant'Anna, Fabio C. Gozzo, Emer S. Ferro, Christiane B. de Araujo, Elisabete R. do Monte, Cristiano Rossato, Leandro M. Castro, Ricardo Pariona Llanos, Vanessa Rioli

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Hundreds of intracellular peptides that are neither antigens nor neuropeptides are present in mammalian cells and tissues. These peptides correspond to fragments of cytosolic, nuclear or mitochondrial proteins. Proteasome inhibition affects the level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3ec9367cb30e5a520494e3747859b4
https://doi.org/10.1016/j.jprot.2016.08.003