Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Lilian Alcaraz"'
Autor:
Vasanthanathan Poongavanam, Emma Danelius, Stefan Peintner, Lilian Alcaraz, Giulia Caron, Maxwell D. Cummings, Stanislaw Wlodek, Mate Erdelyi, Paul C. D. Hawkins, Giuseppe Ermondi, Jan Kihlberg
Publikováno v:
ACS Omega, Vol 3, Iss 9, Pp 11742-11757 (2018)
Externí odkaz:
https://doaj.org/article/07e72e396ed549dcb40e2ec05e7d1b90
Autor:
Maria Lilian Alcaraz, Élise Labonté-LeMoyne, Sonia Lupien, Sylvain Sénécal, Ann-Frances Cameron, François Bellavance, Pierre-Majorique Léger
Publikováno v:
Frontiers in Psychology, Vol 13 (2022)
Texting while walking (TWW) is a dangerous behavior that can lead to injury and even death. While several studies have examined the relationship between smartphone use and stress, to our knowledge no studies have yet investigated the relationship bet
Externí odkaz:
https://doaj.org/article/51ea390b0e3b4bf584d9af8241e494da
Autor:
Elisabetta Armani, Carmelida Capaldi, Valentina Bagnacani, Francesca Saccani, Giancarlo Aquino, Paola Puccini, Fabrizio Facchinetti, Cataldo Martucci, Nadia Moretto, Gino Villetti, Riccardo Patacchini, Maurizio Civelli, Chris Hurley, Andrew Jennings, Lilian Alcaraz, Dawn Bloomfield, Michael Briggs, Stephen Daly, Terry Panchal, Vince Russell, Sharon Wicks, Harry Finch, Mary Fitzgerald, Craig Fox, Maurizio Delcanale
Publikováno v:
Journal of Medicinal Chemistry. 65:7170-7192
The identification of novel inhaled p38α/β mitogen-activated protein kinases (MAPK) (MAPK14/11) inhibitors suitable for the treatment of pulmonary inflammatory conditions has been described. A rational drug design approach started from the identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479680e047f3d911cb0616fbd692706c
https://doi.org/10.1021/acs.jmedchem.2c00115
https://doi.org/10.1021/acs.jmedchem.2c00115
Publikováno v:
Revista EntreLínguas, Vol 5, Iss 1 (2019)
Part of a research project in learning narratives, this paper tries to map the experience of three former university students of Portuguese as a foreign language (PLE), who graduated from the College of Exact and Natural Sciences (FaCEN), Paraguay, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ca2a40e531c860d5c7095171b19b19
https://doi.org/10.29051/el.v5i1.12599
https://doi.org/10.29051/el.v5i1.12599
Autor:
Emma Danelius, Jan Kihlberg, Lilian Alcaraz, Máté Erdélyi, Maxwell D. Cummings, Giulia Caron, Giuseppe Ermondi, Paul C. D. Hawkins, Stanislaw Wlodek, Stefan Peintner, Vasanthanathan Poongavanam
Publikováno v:
ACS Omega, Vol 3, Iss 9, Pp 11742-11757 (2018)
ACS Omega
ACS Omega
Conformational flexibility is a major determinant of the properties of macrocycles and other drugs in beyond rule of 5 (bRo5) space. Prediction of conforrriations is essential for design of drugs in this space, and we have evaluated three tools for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1721aa41432b0145a9fc1f33971f4fca
https://doaj.org/article/07e72e396ed549dcb40e2ec05e7d1b90
https://doaj.org/article/07e72e396ed549dcb40e2ec05e7d1b90
Autor:
Lilian Alcaraz, Michael J. Stocks
Publikováno v:
Lead Generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8831b3473117f4666642c5e44ed5f14b
https://doi.org/10.1002/9783527677047.ch20
https://doi.org/10.1002/9783527677047.ch20
Autor:
Elizabeth Kinchin, Lilian Alcaraz, Aaron Rigby, Haydn Beaton, Matt Soars, Rebecca Denton, Keith Bowers, Ash Bahl, David Donald, John Collington, Cathy MacDonald, Rob Riley, Peter J. H. Webborn, Christopher A. Luckhurst, Brian Springthorpe, Mark Furber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7702-7706
The discovery of potent small molecule dual antagonists of the human CCR3 and H(1) receptors is described for the treatment of allergic diseases, for example, asthma and allergic rhinitis. Optimizing in vitro potency and metabolic stability, starting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326676355fb09074d590653a96585ff3
https://doi.org/10.1016/j.bmcl.2012.09.113
https://doi.org/10.1016/j.bmcl.2012.09.113
Autor:
Aaron Rigby, Peter J. H. Webborn, Rob Riley, John Collington, Mark Furber, Brian Springthorpe, Matt Soars, Ash Bahl, Cathy MacDonald, Keith Bowers, Elizabeth Kinchin, Lilian Alcaraz, Rebecca Denton, Haydn Beaton, David Donald, Christopher A. Luckhurst
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7707-7710
The second part of this communication focuses on the resolution of issues surrounding the series of hydroxyamide phenoxypiperidine CCR3/H(1) dual antagonists described in Part I. This involved further structural exploration directed at reducing metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a2660289e12b8effe0ecbfde4d5f050
https://doi.org/10.1016/j.bmcl.2012.09.112
https://doi.org/10.1016/j.bmcl.2012.09.112
Autor:
Yingpeng Su, Michael J. Stocks, Jieping Zhu, Géraldine Masson, Lilian Alcaraz, Marinus J. Bouma, Mark Furber
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2012, 18 (40), pp.12624-7. ⟨10.1002/chem.201202174⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2012, 18 (40), pp.12624-7. ⟨10.1002/chem.201202174⟩
International audience; Enantioselective multicomponent reaction: In the presence of a catalytic amount of chiral BINOL-derived phosphoric acid (TRIP), the reaction of an α-isocyanoacetate 1, an aldehyde 2, and an aniline 3, followed by addition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60bf378329ba8679b88c098fc0ae29e
https://doi.org/10.1002/chem.201202174
https://doi.org/10.1002/chem.201202174
From libraries to candidate: The discovery of new ultra long-acting dibasic β2-adrenoceptor agonists
Autor:
Stephen Connolly, Stephen Jordan, Stuart W. Paine, Phillip Thorne, Nicholas Kindon, Andrew Bailey, Alexander K. Mullen, I.A. Dainty, Mandy Lawson, David J. Nicholls, Garry Pairaudeau, Robert Jewell, Lilian Alcaraz, Michael J. Stocks, Alan Young, Elaine Cadogan, Andrew Lister
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:689-695
Libraries of dibasic compounds designed around the molecular scaffold of the DA2/β2 dual agonist sibenadet (Viozan™) have yielded a number of promising starting points that have been further optimised into novel potent and selective target molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f25451a0d52745e54b03d8b41df2023
https://doi.org/10.1016/j.bmcl.2011.10.049
https://doi.org/10.1016/j.bmcl.2011.10.049