Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Lilian, Hernández Alvarez"'
1
Akademický článek
Computational study on the allosteric mechanism of Leishmania major IF4E-1 by 4E-interacting protein-1: Unravelling the determinants of m7GTP cap recognition
Autor: Lilian Hernández-Alvarez, Antonio B Oliveira Jr, Jorge Enrique Hernández-González, Jorge Chahine, Pedro Geraldo Pascutti, Alexandre Suman de Araujo, Fátima Pereira de Souza
Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2027-2044 (2021)
During their life cycle, Leishmania parasites display a fine-tuned regulation of the mRNA translation through the differential expression of isoforms of eukaryotic translation initiation factor 4E (LeishIF4Es). The interaction between allosteric modu
Externí odkaz: https://doaj.org/article/6ead92ed6d4f49e786c537950ff4a455
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2
Akademický článek
Dissecting a novel allosteric mechanism of cruzain: A computer-aided approach.
Autor: Lilian Hernández Alvarez, Diego Enry Barreto Gomes, Jorge Enrique Hernández González, Pedro Geraldo Pascutti
Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0211227 (2019)
Trypanosoma cruzi is the causative agent of Chagas disease, a neglected infection affecting millions of people in tropical regions. There are several chemotherapeutic agents for the treatment of this disease, but most of them are highly toxic and gen
Externí odkaz: https://doaj.org/article/b249e55470ec4b2bb6860120a89b8e61
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3
In silico identification of noncompetitive inhibitors targeting an uncharacterized allosteric site of falcipain-2
Autor: Chris Oostenbrink, Vitor B. P. Leite, Diego E. B. Gomes, Emir Salas-Sarduy, Pedro G. Pascutti, Lilian Hernández Alvarez, Jorge Enrique Hernández González
Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2022-04-29T08:35:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) Falcipain-2 (FP-2) is a Plasmodium falciparum hemoglobinase widely targ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e9054cbb1d556c1f4b9b54a61b2ea1
https://doi.org/10.1007/s10822-021-00420-7
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4
Akademický článek
Insights into the Interactions of Fasciola hepatica Cathepsin L3 with a Substrate and Potential Novel Inhibitors through In Silico Approaches.
Autor: Lilian Hernández Alvarez, Dany Naranjo Feliciano, Jorge Enrique Hernández González, R O Soares, Diego Enry Barreto Gomes, Pedro Geraldo Pascutti
Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 5, p e0003759 (2015)
BACKGROUND:Fasciola hepatica is the causative agent of fascioliasis, a disease affecting grazing animals, causing economic losses in global agriculture and currently being an important human zoonosis. Overuse of chemotherapeutics against fascioliasis
Externí odkaz: https://doaj.org/article/a3fafc32fcbc40b29fbdb1dc4795c627
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5
Prediction of Noncompetitive Inhibitor Binding Mode Reveals Promising Site for Allosteric Modulation of Falcipain-2
Autor: Vitor B. P. Leite, Pedro Geraldo Pascutti, Lilian Hernández Alvarez, Jorge Enrique Hernández González
Publikováno v: The Journal of Physical Chemistry B. 123:7327-7342
Falcipain-2 (FP-2) is a Plasmodium falciparum cysteine protease that has been extensively targeted to identify novel antimalarials. Remarkably, previous reports have shown that FP-2 can be allosterically modulated and, for a particular noncompetitive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f9946df0a67d64a3e6fb2ea00b8705
https://doi.org/10.1021/acs.jpcb.9b05021
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6
In silico identification of noncompetitive inhibitors targeting an uncharacterized allosteric site of falcipain-2
Autor: Jorge Enrique, Hernández González, Emir, Salas-Sarduy, Lilian, Hernández Alvarez, Diego Enry, Barreto Gomes, Pedro Geraldo, Pascutti, Chris, Oostenbrink, Vitor B P, Leite
Publikováno v: Journal of computer-aided molecular design. 35(10)
Falcipain-2 (FP-2) is a Plasmodium falciparum hemoglobinase widely targeted in the search for antimalarials. FP-2 can be allosterically modulated by various noncompetitive inhibitors that have been serendipitously identified. Moreover, the crystal st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37126fde44d581c4dc16eb31a9924402
https://pubmed.ncbi.nlm.nih.gov/34617191
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7
Water Bridges Play a Key Role in Affinity and Selectivity for Malarial Protease Falcipain-2
Autor: Pedro Geraldo Pascutti, Vitor B. P. Leite, Jorge E. Hernández-González, Lilian Hernández Alvarez
Publikováno v: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2021-06-25T12:27:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-11-23 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3e2940d2386e21d7a8d0cecd09d0bf
https://pubmed.ncbi.nlm.nih.gov/32634311
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8
Predicting binding modes of reversible peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships
Autor: Pedro Geraldo Pascutti, Jorge Enrique Hernández González, Pedro A. Valiente, Lilian Hernández Alvarez
Publikováno v: Proteins: Structure, Function, and Bioinformatics. 85:1666-1683
Falcipain-2 (FP-2) is a major hemoglobinase of Plasmodium falciparum, considered an important drug target for the development of antimalarials. A previous study reported a novel series of twenty reversible peptide-based inhibitors of FP-2. However, t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80a1becbac944ba2a7a601cc926e9243
https://doi.org/10.1002/prot.25322
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9
Dissecting a novel allosteric mechanism of cruzain: A computer-aided approach
Autor: Lilian Hernández Alvarez, Diego Enry Barreto Gomes, Pedro Geraldo Pascutti, Jorge Enrique Hernández González
Publikováno v: PLoS ONE
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
PLoS ONE, Vol 14, Iss 1, p e0211227 (2019)
Made available in DSpace on 2019-10-04T12:34:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-25 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Try
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadf40d2180953b3c950b684edbbcd63
https://pubmed.ncbi.nlm.nih.gov/30682119
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10
Predicting binding modes of reversible peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships
Autor: Jorge Enrique, Hernández González, Lilian, Hernández Alvarez, Pedro Geraldo, Pascutti, Pedro A, Valiente
Publikováno v: Proteins. 85(9)
Falcipain-2 (FP-2) is a major hemoglobinase of Plasmodium falciparum, considered an important drug target for the development of antimalarials. A previous study reported a novel series of 20 reversible peptide-based inhibitors of FP-2. However, the l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ddc3df3c044e9fa81fd2515b7649552d
https://pubmed.ncbi.nlm.nih.gov/28543724
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