Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Lilian, Aly"'
Autor:
Eva Feodora Romahn, Tun Wiltgen, Matthias Bussas, Lilian Aly, Rebecca Wicklein, Christina Noll, Achim Berthele, Vera Dehmelt, Christian Mardin, Claus Zimmer, Thomas Korn, Bernhard Hemmer, Jan S. Kirschke, Mark Mühlau, Benjamin Knier
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundOptical coherence tomography angiography (OCTA) allows non-invasive assessment of retinal vessel structures. Thinning and loss of retinal vessels is evident in eyes of patients with multiple sclerosis (MS) and might be associated with a pro
Externí odkaz:
https://doaj.org/article/d9b4021d6680403390af5349916c62d2
Autor:
Christina Noll, Michael Hiltensperger, Lilian Aly, Rebecca Wicklein, Ali Maisam Afzali, Christian Mardin, Christiane Gasperi, Achim Berthele, Bernhard Hemmer, Thomas Korn, Benjamin Knier
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundOptical coherence tomography angiography (OCT-A) is a novel technique allowing non-invasive assessment of the retinal vasculature. During relapsing remitting multiple sclerosis (RRMS), retinal vessel loss occurs in eyes suffering from acute
Externí odkaz:
https://doaj.org/article/c7a86caea8a545a1a7e986b441348dd5
Autor:
Till F. M. Andlauer, Jenny Link, Dorothea Martin, Malin Ryner, Christina Hermanrud, Verena Grummel, Michael Auer, Harald Hegen, Lilian Aly, Christiane Gasperi, Benjamin Knier, Bertram Müller-Myhsok, Poul Erik Hyldgaard Jensen, Finn Sellebjerg, Ingrid Kockum, Tomas Olsson, Marc Pallardy, Sebastian Spindeldreher, Florian Deisenhammer, Anna Fogdell-Hahn, Bernhard Hemmer, on behalf of the ABIRISK consortium
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-23 (2020)
Abstract Background Upon treatment with biopharmaceuticals, the immune system may produce anti-drug antibodies (ADA) that inhibit the therapy. Up to 40% of multiple sclerosis patients treated with interferon β (IFNβ) develop ADA, for which a geneti
Externí odkaz:
https://doaj.org/article/17f0b4a115a9411898d869c49bd392a4
Autor:
Stefanie Scherer, Susanne G. Oberle, Kristiyan Kanev, Ann-Katrin Gerullis, Ming Wu, Gustavo P. de Almeida, Daniel J. Puleston, Francesc Baixauli, Lilian Aly, Alessandro Greco, Tamar Nizharadze, Nils B. Becker, Madlaina v. Hoesslin, Lara V. Donhauser, Jacqueline Berner, Talyn Chu, Hayley A. McNamara, Zeynep Esencan, Patrick Roelli, Christine Wurmser, Ingo Kleiter, Maria J. G. T. Vehreschild, Christoph A. Mayer, Percy Knolle, Martin Klingenspor, Valeria Fumagalli, Matteo Iannacone, Martin Prlic, Thomas Korn, Erika L. Pearce, Thomas Höfer, Anna M. Schulz, Dietmar Zehn
Publikováno v:
Nature Immunology
Blocking pyrimidine de novo synthesis by inhibiting dihydroorotate dehydrogenase is used to treat autoimmunity and prevent expansion of rapidly dividing cell populations including activated T cells. Here we show memory T cell precursors are resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085f2909a004801c889c7b71682d6c58
https://doi.org/10.1038/s41590-023-01436-x
https://doi.org/10.1038/s41590-023-01436-x
Autor:
Josephine Wauschkuhn, Gilberto Solorza Buenrostro, Lilian Aly, Susanna Asseyer, Rebecca Wicklein, Julia Maria Hartberger, Klemens Ruprecht, Mark Mühlau, Tanja Schmitz‐Hübsch, Claudia Chien, Achim Berthele, Alexander U. Brandt, Thomas Korn, Friedemann Paul, Bernhard Hemmer, Hanna G. Zimmermann, Benjamin Knier
Publikováno v:
European Journal of Neurology. 30:982-990
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::661d70306856c41d57af0665507fba58
https://doi.org/10.1111/ene.15681
https://doi.org/10.1111/ene.15681
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
Autor:
Garima Garg, Andreas Muschaweckh, Helena Moreno, Ajithkumar Vasanthakumar, Stefan Floess, Gildas Lepennetier, Rupert Oellinger, Yifan Zhan, Tommy Regen, Michael Hiltensperger, Christian Peter, Lilian Aly, Benjamin Knier, Lakshmi Reddy Palam, Reuben Kapur, Mark H. Kaplan, Ari Waisman, Roland Rad, Gunnar Schotta, Jochen Huehn, Axel Kallies, Thomas Korn
Publikováno v:
Cell Reports, Vol 26, Iss 7, Pp 1854-1868.e5 (2019)
Summary: Foxp3+ regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an inflammatory environment presents a threat to Treg cell identity and function. Here, we establish a transcriptional signature of central nervous syst
Externí odkaz:
https://doaj.org/article/1003c933a1db470eb7a891336e58a0bb
Autor:
Ali Maisam Afzali, Lasse Stüve, Monika Pfaller, Lilian Aly, Katja Steiger, Benjamin Knier, Thomas Korn
Publikováno v:
Journal of Molecular Medicine. 100:933-946
Abstract Aquaporin-4 (AQP4) is the molecular target of the immune response in neuromyelitis optica (NMO) that leads to severe structural damage in the central nervous system (CNS) and in the retina. Conversely, AQP4 might be upregulated in astrocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171b31323759dfbe2eb52327c457b551
https://doi.org/10.1007/s00109-022-02202-6
https://doi.org/10.1007/s00109-022-02202-6
Autor:
Paulien Baeten, Ibrahim Hamad, Cindy Hoeks, Michael Hiltensperger, Bart Van Wijmeersch, Veronica Popescu, Lilian Aly, Veerle Somers, Thomas Korn, Markus Kleinewietfeld, Niels Hellings, Bieke Broux
In many autoimmune diseases, FOXP3+regulatory T cells (Tregs) skew towards a pro-inflammatory and non-suppressive phenotype and are therefore unable to control the exaggerated autoimmune response. This may largely impact the success of autologous Tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7181f3d74bc7fc174e5735ad8f680daa
https://doi.org/10.1101/2022.10.21.513147
https://doi.org/10.1101/2022.10.21.513147
Autor:
Meike, Mitsdoerffer, Lilian, Aly, Melanie, Barz, Thomas, Engleitner, Christopher, Sie, Claire, Delbridge, Gildas, Lepennetier, Rupert, Öllinger, Monika, Pfaller, Benedikt, Wiestler, Roland, Rad, Bernhard, Meyer, Benjamin, Knier, Friederike, Schmidt-Graf, Jens, Gempt, Thomas, Korn
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(34)
Although glioblastoma multiforme (GBM) is not an invariably cold tumor, checkpoint inhibition has largely failed in GBM. In order to investigate T cell-intrinsic properties that contribute to the resistance of GBM to endogenous or therapeutically enh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2be05b63afdac84f75bac55695c6ed4
https://pubmed.ncbi.nlm.nih.gov/35969754
https://pubmed.ncbi.nlm.nih.gov/35969754
Autor:
Frederike Cosima, Oertel, Elias S, Sotirchos, Hanna G, Zimmermann, Seyedamirhosein, Motamedi, Svenja, Specovius, Eva Susanna, Asseyer, Claudia, Chien, Lawrence, Cook, Eleni, Vasileiou, Angeliki, Filippatou, Peter A, Calabresi, Shiv, Saidha, Lekha, Pandit, Anitha, D'Cunha, Olivier, Outteryck, Hélène, Zéphir, Sean, Pittock, Eoin P, Flanagan, M Tariq, Bhatti, Paulus S, Rommer, Gabriel, Bsteh, Tobias, Zrzavy, Tania, Kuempfel, Orhan, Aktas, Marius, Ringelstein, Philipp, Albrecht, Ilya, Ayzenberg, Thivya, Pakeerathan, Benjamin, Knier, Lilian, Aly, Nasrin, Asgari, Kerstin, Soelberg, Romain, Marignier, Caroline Froment, Tilikete, Alvaro, Cobo Calvo, Pablo, Villoslada, Bernardo, Sanchez-Dalmau, Elena H, Martinez-Lapiscina, Sara, Llufriu, Ari J, Green, Michael R, Yeaman, Terry J, Smith, Alexander U, Brandt, John, Chen, Friedemann, Paul, Joachim, Havla, Caryl, Tongco
Publikováno v:
Annals of neurologyReferences. 92(3)
Patients with myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro-axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04f3852b8ca112ae57d8c29e15cb203
https://pubmed.ncbi.nlm.nih.gov/35703428
https://pubmed.ncbi.nlm.nih.gov/35703428