Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Lilia Weizel"'
Autor:
Marco J. Rotter, Sabrina Zentgraf, Lilia Weizel, Denia Frank, Luisa D. Burgers, Steffen Brunst, Robert Fürst, Anna Proschak, Thomas A. Wichelhaus, Ewgenij Proschak
Publikováno v:
Molecules, Vol 28, Iss 4, p 1984 (2023)
Metallo beta lactamases (MBLs) are among the most problematic resistance mechanisms of multidrug-resistant Gram-negative pathogens due to their broad substrate spectrum and lack of approved inhibitors. In this study, we propose the integration of cat
Externí odkaz:
https://doaj.org/article/07a6b9920e1345b4853cd0c20978c4c0
Autor:
Tamara Göbel, Olaf Diehl, Jan Heering, Daniel Merk, Carlo Angioni, Sandra K. Wittmann, Estel.la Buscato, Ramona Kottke, Lilia Weizel, Tim Schader, Thorsten J. Maier, Gerd Geisslinger, Manfred Schubert-Zsilavecz, Dieter Steinhilber, Ewgenij Proschak, Astrid S. Kahnt
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Cysteinyl leukotriene receptor 1 antagonists (CysLT1RA) are frequently used as add-on medication for the treatment of asthma. Recently, these compounds have shown protective effects in cardiovascular diseases. This prompted us to investigate their in
Externí odkaz:
https://doaj.org/article/a80e026f90b747f8b7674c1f676db0f4
Publikováno v:
Frontiers in Chemistry, Vol 5 (2017)
Neurleptic drugs, e.g., aripiprazole, targeting the dopamine D2S and D3 receptors (D2SR and D3R) in the central nervous system are widely used in the treatment of several psychotic and neurodegenerative diseases. Therefore, a new series of benzothiaz
Externí odkaz:
https://doaj.org/article/29b690108f924318946fa137aec5f65b
Autor:
Steffen Brunst, Julia Schönfeld, Peter Breunig, Luisa D. Burgers, Murphy DeMeglio, Johanna H. M. Ehrler, Felix F. Lillich, Lilia Weizel, Jasmin K. Hefendehl, Robert Fürst, Ewgenij Proschak, Kerstin Hiesinger
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1062-1067
Soluble epoxide hydrolase (sEH) is a promising target for a number of inflammation-related diseases. In addition, inhibition of sEH has been shown to reduce neuroinflammation, which plays a critical role in the development of central nervous system (
Autor:
Cansu Kaya, Jelena Konstantinović, Andreas M. Kany, Anastasia Andreas, Jan S. Kramer, Steffen Brunst, Lilia Weizel, Marco J. Rotter, Denia Frank, Samir Yahiaoui, Rolf Müller, Rolf W. Hartmann, Jörg Haupenthal, Ewgenij Proschak, Thomas A. Wichelhaus, Anna K. H. Hirsch
Publikováno v:
Journal of Medicinal Chemistry. 65:3913-3922
Autor:
Ewgenij Proschak, Anna Proschak, Darina Barkhatova, Igor Solovyev, Thomas A. Wichelhaus, Dmitry Dar'in, Mikhail Krasavin, Steffen Brunst, Denia Frank, Lilia Weizel, Jan S. Kramer, Marco Rotter, Daniil Zhukovsky, Giada Martinelli
Publikováno v:
ChemMedChem. 16:3410-3417
Diversity-oriented synthesis (DOS) is a rich source for novel lead structures in Medicinal Chemistry. In this study, we present a DOS-compatible method for synthesis of compounds bearing a free thiol moiety. The procedure relies on Rh(II)-catalyzed c
Autor:
Riccardo Ronchetti, Jurema Schmidt, Lilia Weizel, Astrid Kaiser, Steffen Brunst, Ewgenij Proschak, Daniel Merk, Moritz Helmstädter
Publikováno v:
Journal of Medicinal Chemistry. 64:9525-9536
Non-alcoholic steatohepatitis (NASH) presents as an epidemic chronic liver disease that is closely associated with metabolic disorders and involves hepatic steatosis, inflammation, and fibrosis as key factors. Despite the enormous global prevalence o
Autor:
Daniel Merk, Ewgenij Proschak, Lilia Weizel, Astrid Kaiser, Moritz Helmstädter, Jurema Schmidt
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Nonalcoholic fatty liver disease (NAFLD) is an epidemic chronic liver disease and may progress over nonalcoholic steatohepatitis (NASH) to liver cirrhosis and hepatocellular carcinoma. The multiple metabolic, environmental, and gene
Autor:
Jan S. Kramer, Marco Rotter, Samir Yahiaoui, Anna K. H. Hirsch, Ewgenij Proschak, Denia Frank, Jörg Haupenthal, Christian Ducho, Steffen Brunst, Katrin Voos, Lilia Weizel, Thomas A. Wichelhaus
Publikováno v:
RSC Medicinal Chemistry
Increasing antimicrobial resistance is evolving to be one of the major threats to public health. To reduce the selection pressure and thus to avoid a fast development of resistance, novel approaches aim to target bacterial virulence instead of growth
Autor:
Mikhail, Krasavin, Daniil, Zhukovsky, Igor, Solovyev, Darina, Barkhatova, Dmitry, Dar'in, Denia, Frank, Giada, Martinelli, Lilia, Weizel, Anna, Proschak, Marco, Rotter, Jan S, Kramer, Steffen, Brunst, Thomas A, Wichelhaus, Ewgenij, Proschak
Publikováno v:
ChemMedChem. 16(22)
Diversity-oriented synthesis (DOS) is a rich source for novel lead structures in Medicinal Chemistry. In this study, we present a DOS-compatible method for synthesis of compounds bearing a free thiol moiety. The procedure relies on Rh(II)-catalyzed c