Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Lilia Magomedova"'
Autor:
Cigdem Sahin, Jenna-Rose Melanson, Florian Le Billan, Lilia Magomedova, Thais A.M. Ferreira, Andressa S. Oliveira, Evan Pollock-Tahari, Michael F. Saikali, Sarah B. Cash, Minna Woo, Luiz A.S. Romeiro, Carolyn L. Cummins
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101958- (2024)
Objective: The prevalence of metabolic diseases is increasing globally at an alarming rate; thus, it is essential that effective, accessible, low-cost therapeutics are developed. Peroxisome proliferator-activated receptors (PPARs) are transcription f
Externí odkaz:
https://doaj.org/article/cfebdf9a904b44948be866fb0310321e
Autor:
Muntasir Kamal, Levon Tokmakjian, Jessica Knox, Duhyun Han, Houtan Moshiri, Lilia Magomedova, Ken Cq Nguyen, Hong Zheng, Andrew R Burns, Brittany Cooke, Jessica Lacoste, May Yeo, David H Hall, Carolyn L Cummins, Peter J Roy
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1011008 (2023)
The cuticles of ecdysozoan animals are barriers to material loss and xenobiotic insult. Key to this barrier is lipid content, the establishment of which is poorly understood. Here, we show that the p-glycoprotein PGP-14 functions coincidently with th
Externí odkaz:
https://doaj.org/article/5c781b6011f44da6a17ddfaf9152fdfb
Autor:
Muntasir Kamal, Houtan Moshiri, Lilia Magomedova, Duhyun Han, Ken C. Q. Nguyen, May Yeo, Jessica Knox, Rachel Bagg, Amy M. Won, Karolina Szlapa, Christopher M. Yip, Carolyn L. Cummins, David H. Hall, Peter J. Roy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The C. elegans nematode worm is a filter-feeder and requires dietary sources of cholesterol. Here, the authors show that the C. elegans pharynx works as a filter to scavenge hydrophobic small molecules from its surrounding liquid environment.
Externí odkaz:
https://doaj.org/article/01ca567f548348c9ac82fe0b636300c0
Autor:
Guy A. Higgins, Nicole K. Carroll, Matt Brown, Cam MacMillan, Leo B. Silenieks, Sandy Thevarkunnel, Julia Izhakova, Lilia Magomedova, Ines DeLannoy, Edward M. Sellers
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Long term benefits following short-term administration of high psychedelic doses of serotonergic and dissociative hallucinogens, typified by psilocybin and ketamine respectively, support their potential as treatments for psychiatric conditions such a
Externí odkaz:
https://doaj.org/article/60248d7199844455b8f88ef139c114c6
Autor:
Jens Tiefenbach, Lilia Magomedova, Jiabao Liu, Arkadiy A. Reunov, Ricky Tsai, Neena S. Eappen, Rebecca A. Jockusch, Corey Nislow, Carolyn L. Cummins, Henry M. Krause
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Current peroxisome proliferator-activated receptor (PPAR)-targeted drugs, such as the PPARγ-directed diabetes drug rosiglitazone, are associated with undesirable side effects due to robust agonist activity in non-target tissues. To find new PPAR lig
Externí odkaz:
https://doaj.org/article/725afbfba88d4a8cb07d45d378db7066
Autor:
Joshua Wollam, Daniel B Magner, Lilia Magomedova, Elisabeth Rass, Yidong Shen, Veerle Rottiers, Bianca Habermann, Carolyn L Cummins, Adam Antebi
Publikováno v:
PLoS Biology, Vol 10, Iss 4, p e1001305 (2012)
Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel means to influence health and life span. In C. elegans, bile acid-like steroids called the dafachronic acids (DAs) regulate developmental timing and longevit
Externí odkaz:
https://doaj.org/article/1fbb10ee35964a4ea240eed92e350721
Autor:
Cigdem Sahin, Lilia Magomedova, Thais A. M. Ferreira, Jiabao Liu, Jens Tiefenbach, Priscilla S. Alves, Fellipe J. G. Queiroz, Andressa S. de Oliveira, Mousumi Bhattacharyya, Julie Grouleff, Patrícia C. N. Nogueira, Edilberto R. Silveira, Daniel C. Moreira, José Roberto Souza de Almeida Leite, Guilherme D. Brand, David Uehling, Gennady Poda, Henry Krause, Carolyn L. Cummins, Luiz A. S. Romeiro
Publikováno v:
Journal of Medicinal Chemistry. 65:1961-1978
Metabolic diseases are increasing at staggering rates globally. The peroxisome proliferator-activated receptors (PPARα/γ/δ) are fatty acid sensors that help mitigate imbalances between energy uptake and utilization. Herein, we report compounds der
Autor:
Jiabao, Liu, Cigdem, Sahin, Samar, Ahmad, Lilia, Magomedova, Minhao, Zhang, Zhengping, Jia, Adam H, Metherel, Arturo, Orellana, Gennady, Poda, Richard P, Bazinet, Liliana, Attisano, Carolyn L, Cummins, Hui, Peng, Henry M, Krause
Publikováno v:
Science signaling. 15(741)
The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) is emerging as an important target in the brain for the treatment or prevention of cognitive disorders. The identification of high-affinity ligands for brain PPARα may re
Autor:
Florian Le Billan, Stephane Angers, Mélanie Robitaille, Henry M. Krause, Quaid Morris, Carolyn L. Cummins, Debashish Ray, Vincent Boivin, Timothy P. Hughes, Benjamin J. Blencowe, Michelle S. Scott, Serge Gueroussov, Rucha Patel, Michael F. Saikali, Lilia Magomedova, Chao Xu, Emma Zilberman, Jens Tiefenbach, Pancharatnam Jeyasuria, Veronique Voisin, Gary D. Bader, Manuel Irimia
Publikováno v:
Nucleic Acids Research
Stress hormones bind and activate the glucocorticoid receptor (GR) in many tissues including the brain. We identified arginine and glutamate rich 1 (ARGLU1) in a screen for new modulators of glucocorticoid signaling in the CNS. Biochemical studies sh
Autor:
Edwin C. Y. Chow, Hiroshi Saitoh, Albert P. Li, Paola Bukuroshi, K. Sandy Pang, Lilia Magomedova, Carolyn L. Cummins
Publikováno v:
Biochemical Pharmacology. 155:547-561
In vitro cell-based assays are common screening tools used for the identification of new VDR ligands. For 25-hydroxyvitamin D3 [25(OH)D3] and 1α-hydroxyvitamin D3 [1α(OH)D3], protein expressions of CYP2R1 and CYP27B1, respectively, that form the ac